TY - JOUR

T1 - Patient self-testing of white blood cell count and differentiation

T2 - A study of feasibility and measurement performance in a population of Danish cancer patients

AU - Otto Mattsson, Thea

AU - Lindhart, Christina Louise

AU - Schöley, Jonas

AU - Friis-Hansen, Lennart

AU - Herrstedt, Jørn

N1 - Publisher Copyright: © 2019 John Wiley & Sons Ltd

PY - 2020

Y1 - 2020

N2 - Objective: Patients in anticancer treatment with a known side effect of neutropenia are monitored closely with laboratory measurements of white blood cell count (WBC) and differentiation. This study sought to evaluate measurement properties and feasibility of patients' self-testing using a point-of-care testing (POCT) device. Methods: A prospective feasibility and measurement study comparing the standard measurement of cancer patients' WBC and neutrophil count with POCT measurements. The study included 60 outpatients and 22 inpatients from a department of oncology at a university hospital. Results: Patients successfully conducted 106 measurements using the POCT device. 46% of the patients were >70 years. Weighted Deming regression analysis showed minimal yet significant proportional bias between methods, with POCT increasingly underestimating both total WBC and neutrophils compared with the standard method the higher the count. Over 90% of patients reported they were willing and considered themselves able to use the POCT device at home. Conclusions: The instrument can be used for self-testing of post-anticancer leukopenia and has sufficient measurement precision for patient risk stratification. Patients are able and willing to conduct measurements including when in a situation of acute illness. Further studies are needed to confirm safety and value within patients’ own home.

AB - Objective: Patients in anticancer treatment with a known side effect of neutropenia are monitored closely with laboratory measurements of white blood cell count (WBC) and differentiation. This study sought to evaluate measurement properties and feasibility of patients' self-testing using a point-of-care testing (POCT) device. Methods: A prospective feasibility and measurement study comparing the standard measurement of cancer patients' WBC and neutrophil count with POCT measurements. The study included 60 outpatients and 22 inpatients from a department of oncology at a university hospital. Results: Patients successfully conducted 106 measurements using the POCT device. 46% of the patients were >70 years. Weighted Deming regression analysis showed minimal yet significant proportional bias between methods, with POCT increasingly underestimating both total WBC and neutrophils compared with the standard method the higher the count. Over 90% of patients reported they were willing and considered themselves able to use the POCT device at home. Conclusions: The instrument can be used for self-testing of post-anticancer leukopenia and has sufficient measurement precision for patient risk stratification. Patients are able and willing to conduct measurements including when in a situation of acute illness. Further studies are needed to confirm safety and value within patients’ own home.

KW - aged

KW - antineoplastic agents

KW - febrile neutropenia

KW - medical oncology

KW - patient comfort

KW - patient education

KW - point-of-care testing

UR - http://www.scopus.com/inward/record.url?scp=85075201182&partnerID=8YFLogxK

U2 - 10.1111/ecc.13189

DO - 10.1111/ecc.13189

M3 - Journal article

C2 - 31746087

AN - SCOPUS:85075201182

VL - 29

JO - European Journal of Cancer Care

JF - European Journal of Cancer Care

SN - 0961-5423

IS - 1

M1 - e13189

ER -