Patient reported exposure to smoking and alcohol abuse are associated with pain and other complications in patients with chronic pancreatitis
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Patient reported exposure to smoking and alcohol abuse are associated with pain and other complications in patients with chronic pancreatitis. / Tjora, Erling; Dimcevski, Georg; Haas, Stephan L; Erchinger, Friedemann; Vujasinovic, Miroslav; Löhr, Matthias; Nøjgaard, Camilla; Novovic, Srdan; Zalite, Imanta Ozola; Pukitis, Aldis; Hauge, Truls; Waage, Anne; Roug, Stine; Kalaitzakis, Evangelos; Lindkvist, Björn; Olesen, Søren Schou; Engjom, Trond; Scandinavian Baltic Pancreatic Club.
I: Pancreatology, Bind 20, Nr. 5, 2020, s. 844-851.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Patient reported exposure to smoking and alcohol abuse are associated with pain and other complications in patients with chronic pancreatitis
AU - Tjora, Erling
AU - Dimcevski, Georg
AU - Haas, Stephan L
AU - Erchinger, Friedemann
AU - Vujasinovic, Miroslav
AU - Löhr, Matthias
AU - Nøjgaard, Camilla
AU - Novovic, Srdan
AU - Zalite, Imanta Ozola
AU - Pukitis, Aldis
AU - Hauge, Truls
AU - Waage, Anne
AU - Roug, Stine
AU - Kalaitzakis, Evangelos
AU - Lindkvist, Björn
AU - Olesen, Søren Schou
AU - Engjom, Trond
AU - Scandinavian Baltic Pancreatic Club
N1 - Copyright © 2020 IAP and EPC. Published by Elsevier B.V. All rights reserved.
PY - 2020
Y1 - 2020
N2 - BACKGROUND/OBJECTIVES: Smoking and alcohol abuse are established risk factors for chronic pancreatitis (CP). Few studies have examined how exposure to smoking and alcohol abuse act as risk factors for complications in CP. Our aim was to examine associations between patient reported exposure to smoking and alcohol abuse and complications in CP in a large cohort of patients from the Scandinavian and Baltic countries.METHODS: We retrieved data on demographics, CP related complications and patients' histories of exposure to smoking and alcohol abuse from the Scandinavian Baltic Pancreatic Club database. Associations were investigated by univariate and multivariate logistic regression analyses. Results are presented as odds ratios (OR) with 95% confidence intervals.RESULTS: A complete history of smoking and alcohol exposure was available for 932 patients. In multivariate regression analyses, the presence of pain and exocrine pancreatic insufficiency were both significantly associated with history of smoking (OR 1.94 (1.40-2.68), p < 0.001 and OR 1.89 (1.36-2.62), p < 0.001, respectively) and alcohol abuse (OR 1.66 (1.21-2.26), p = 0.001 and 1.55 (1.14-2.11), p = 0.005, respectively). Smoking was associated with calcifications (OR 2.89 (2.09-3.96), p < 0.001), moderate to severe ductal changes (OR 1.42 (1.05-1.92), p = 0.02), and underweight (OR 4.73 (2.23-10.02), p < 0.001). History of alcohol abuse was associated with pseudocysts (OR 1.38 (1.00-1.90) p = 0.05) and diabetes mellitus (OR 1.44 (1.03-2.01), p = 0.03). There were significantly increased odds-ratios for several complications with increasing exposure to smoking and alcohol abuse.CONCLUSION: Smoking and alcohol abuse are both independently associated with development of complications in patients with CP. There seems to be a dose-dependent relationship between smoking and alcohol abuse and complications in CP.
AB - BACKGROUND/OBJECTIVES: Smoking and alcohol abuse are established risk factors for chronic pancreatitis (CP). Few studies have examined how exposure to smoking and alcohol abuse act as risk factors for complications in CP. Our aim was to examine associations between patient reported exposure to smoking and alcohol abuse and complications in CP in a large cohort of patients from the Scandinavian and Baltic countries.METHODS: We retrieved data on demographics, CP related complications and patients' histories of exposure to smoking and alcohol abuse from the Scandinavian Baltic Pancreatic Club database. Associations were investigated by univariate and multivariate logistic regression analyses. Results are presented as odds ratios (OR) with 95% confidence intervals.RESULTS: A complete history of smoking and alcohol exposure was available for 932 patients. In multivariate regression analyses, the presence of pain and exocrine pancreatic insufficiency were both significantly associated with history of smoking (OR 1.94 (1.40-2.68), p < 0.001 and OR 1.89 (1.36-2.62), p < 0.001, respectively) and alcohol abuse (OR 1.66 (1.21-2.26), p = 0.001 and 1.55 (1.14-2.11), p = 0.005, respectively). Smoking was associated with calcifications (OR 2.89 (2.09-3.96), p < 0.001), moderate to severe ductal changes (OR 1.42 (1.05-1.92), p = 0.02), and underweight (OR 4.73 (2.23-10.02), p < 0.001). History of alcohol abuse was associated with pseudocysts (OR 1.38 (1.00-1.90) p = 0.05) and diabetes mellitus (OR 1.44 (1.03-2.01), p = 0.03). There were significantly increased odds-ratios for several complications with increasing exposure to smoking and alcohol abuse.CONCLUSION: Smoking and alcohol abuse are both independently associated with development of complications in patients with CP. There seems to be a dose-dependent relationship between smoking and alcohol abuse and complications in CP.
U2 - 10.1016/j.pan.2020.05.001
DO - 10.1016/j.pan.2020.05.001
M3 - Journal article
C2 - 32507681
VL - 20
SP - 844
EP - 851
JO - Pancreatology
JF - Pancreatology
SN - 1424-3903
IS - 5
ER -
ID: 256577356