Pathological gambling: Relation of skin conductance response to dopaminergic neurotransmission and sensation-seeking
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Pathological gambling: Relation of skin conductance response to dopaminergic neurotransmission and sensation-seeking. / Peterson, Ericka Ann; Møller, Arne; Doudet, Doris J.; Bailey, Christopher; Hansen, Kim Vang; Rodell, Anders; Linnet, Jakob; Gjedde, Albert.
I: European Neuropsychopharmacology, Bind 20, Nr. 11, 11.2010, s. 766-75.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Pathological gambling: Relation of skin conductance response to dopaminergic neurotransmission and sensation-seeking
AU - Peterson, Ericka Ann
AU - Møller, Arne
AU - Doudet, Doris J.
AU - Bailey, Christopher
AU - Hansen, Kim Vang
AU - Rodell, Anders
AU - Linnet, Jakob
AU - Gjedde, Albert
PY - 2010/11
Y1 - 2010/11
N2 - Absent Skin Conductance Response (SCR) in pathological gambling (PG) may relate to dopaminergic mechanisms. We recruited equal numbers of PG subjects and healthy control (HC) subjects, and then tested the claim that SCR is less conditioned by dopaminergic activity in PG subjects. During active gambling, SCR differed in PG and HC subjects (P < 0.05), but positron emission tomography revealed the same dopamine receptor availability. However, highly sensation-seeking (HS) PG subjects had lower dopamine receptor availability (P < 0.0001) in the baseline, compared to normal sensation-seeking (NS) PG subjects. We find that HS versus NS controls had the same observation of significant increase of binding potential (BP(ND)) in high compared to normal sensation seekers. In both groups, PG and HC, highly sensation-seeking subjects had significant increase of receptor availability in striatum, compared to normally sensation-seeking subjects, separately (P < 0.05 and P = 0.02, respectively) and together (P < 0.0005). We conclude that SCR is less conditioned by dopaminergic activity in highly sensation-seeking subjects, regardless of PG status
AB - Absent Skin Conductance Response (SCR) in pathological gambling (PG) may relate to dopaminergic mechanisms. We recruited equal numbers of PG subjects and healthy control (HC) subjects, and then tested the claim that SCR is less conditioned by dopaminergic activity in PG subjects. During active gambling, SCR differed in PG and HC subjects (P < 0.05), but positron emission tomography revealed the same dopamine receptor availability. However, highly sensation-seeking (HS) PG subjects had lower dopamine receptor availability (P < 0.0001) in the baseline, compared to normal sensation-seeking (NS) PG subjects. We find that HS versus NS controls had the same observation of significant increase of binding potential (BP(ND)) in high compared to normal sensation seekers. In both groups, PG and HC, highly sensation-seeking subjects had significant increase of receptor availability in striatum, compared to normally sensation-seeking subjects, separately (P < 0.05 and P = 0.02, respectively) and together (P < 0.0005). We conclude that SCR is less conditioned by dopaminergic activity in highly sensation-seeking subjects, regardless of PG status
U2 - doi:10.1016/j.euroneuro.2010.07.010
DO - doi:10.1016/j.euroneuro.2010.07.010
M3 - Journal article
VL - 20
SP - 766
EP - 775
JO - European Neuropsychopharmacology
JF - European Neuropsychopharmacology
SN - 0924-977X
IS - 11
ER -
ID: 33882398