Patch testing with 2.0% (0.60 mg/cm(2) ) formaldehyde instead of 1.0% (0.30 mg/cm(2) ) detects significantly more contact allergy
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Patch testing with 2.0% (0.60 mg/cm(2) ) formaldehyde instead of 1.0% (0.30 mg/cm(2) ) detects significantly more contact allergy. / Pontén, Ann; Aalto-Korte, Kristiina; Agner, Tove; Andersen, Klaus Ejner; Giménez-Arnau, Ana M; Gonçalo, Margarida; Goossens, An; Johansen, Jeanne D; Le Coz, Christophe J; Maibach, Howard I; Rustemeyer, Thomas; White, Ian R; Bruze, Magnus.
I: Contact Dermatitis, Bind 68, Nr. 1, 2013, s. 50-53.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Patch testing with 2.0% (0.60 mg/cm(2) ) formaldehyde instead of 1.0% (0.30 mg/cm(2) ) detects significantly more contact allergy
AU - Pontén, Ann
AU - Aalto-Korte, Kristiina
AU - Agner, Tove
AU - Andersen, Klaus Ejner
AU - Giménez-Arnau, Ana M
AU - Gonçalo, Margarida
AU - Goossens, An
AU - Johansen, Jeanne D
AU - Le Coz, Christophe J
AU - Maibach, Howard I
AU - Rustemeyer, Thomas
AU - White, Ian R
AU - Bruze, Magnus
N1 - © 2012 John Wiley & Sons A/S.
PY - 2013
Y1 - 2013
N2 - Background.The currently used patch test concentration for formaldehyde is 1.0% (wt/vol) in water. However, clinical experience and previous studies suggest that 1.0% might be insufficient for detecting an optimized number of clinically relevant cases of contact allergy to formaldehyde. Objectives.To validate earlier patch test results for comparison of 1% (wt/vol) and 2% (wt/vol) formaldehyde in water, and to investigate co-reactivity with quaternium-15. Materials and methods.In 12 dermatology clinics, 3591 patients were routinely patch tested simultaneously with 2.0% (wt/vol) (0.60 mg/cm(2) ) and 1.0% (wt/vol) (0.30 mg/cm(2) ) formaldehyde. Micropipettes were used for delivering the exact dosage of the allergen. Results.Significantly more patients reacted to 2.0% formaldehyde than to 1.0% (3.4% versus 1.8%, p <0.001). Overall, there were no sex differences between those reacting positively to 2.0% and 1.0%. Of 25 quaternium-15-positive patients, 4 (0.1%) reacted positively without reacting to formaldehyde. Conclusion.On the basis of the results of this multicentre study, as well as of previous studies, it can be suggested that 2.0% (wt/vol) in water formaldehyde should be used in routine patch testing in the baseline series.
AB - Background.The currently used patch test concentration for formaldehyde is 1.0% (wt/vol) in water. However, clinical experience and previous studies suggest that 1.0% might be insufficient for detecting an optimized number of clinically relevant cases of contact allergy to formaldehyde. Objectives.To validate earlier patch test results for comparison of 1% (wt/vol) and 2% (wt/vol) formaldehyde in water, and to investigate co-reactivity with quaternium-15. Materials and methods.In 12 dermatology clinics, 3591 patients were routinely patch tested simultaneously with 2.0% (wt/vol) (0.60 mg/cm(2) ) and 1.0% (wt/vol) (0.30 mg/cm(2) ) formaldehyde. Micropipettes were used for delivering the exact dosage of the allergen. Results.Significantly more patients reacted to 2.0% formaldehyde than to 1.0% (3.4% versus 1.8%, p <0.001). Overall, there were no sex differences between those reacting positively to 2.0% and 1.0%. Of 25 quaternium-15-positive patients, 4 (0.1%) reacted positively without reacting to formaldehyde. Conclusion.On the basis of the results of this multicentre study, as well as of previous studies, it can be suggested that 2.0% (wt/vol) in water formaldehyde should be used in routine patch testing in the baseline series.
U2 - 10.1111/j.1600-0536.2012.02169.x
DO - 10.1111/j.1600-0536.2012.02169.x
M3 - Journal article
C2 - 23035891
VL - 68
SP - 50
EP - 53
JO - Contact Dermatitis
JF - Contact Dermatitis
SN - 0105-1873
IS - 1
ER -
ID: 48414512