Parental occupational exposure to pesticides, animals and organic dust and risk of childhood leukemia and central nervous system tumors

Parental occupational exposure to pesticides, animals and organic dust and risk of childhood leukemia and central nervous system tumors: Findings from the International Childhood Cancer Cohort Consortium (I4C)

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

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Parental occupational exposure to pesticides, animals and organic dust and risk of childhood leukemia and central nervous system tumors : Findings from the International Childhood Cancer Cohort Consortium (I4C). / Patel, Deven M.; Jones, Rena R.; Booth, Benjamin J.; Olsson, Ann C.; Kromhout, Hans; Straif, Kurt; Vermeulen, Roel; Tikellis, Gabriella; Paltiel, Ora; Golding, Jean; Northstone, Kate; Stoltenberg, Camilla; Håberg, Siri E.; Schüz, Joachim; Friesen, Melissa C.; Ponsonby, Anne Louise; Lemeshow, Stanley; Linet, Martha S.; Magnus, Per; Olsen, Jørn; Olsen, Sjurdur F.; Dwyer, Terence; Stayner, Leslie T.; Ward, Mary H.; on behalf of the International Childhood Cancer Cohort Consortium.

I: International Journal of Cancer, Bind 146, Nr. 4, 2020, s. 943-952.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Patel, DM, Jones, RR, Booth, BJ, Olsson, AC, Kromhout, H, Straif, K, Vermeulen, R, Tikellis, G, Paltiel, O, Golding, J, Northstone, K, Stoltenberg, C, Håberg, SE, Schüz, J, Friesen, MC, Ponsonby, AL, Lemeshow, S, Linet, MS, Magnus, P, Olsen, J, Olsen, SF, Dwyer, T, Stayner, LT, Ward, MH & on behalf of the International Childhood Cancer Cohort Consortium 2020, 'Parental occupational exposure to pesticides, animals and organic dust and risk of childhood leukemia and central nervous system tumors: Findings from the International Childhood Cancer Cohort Consortium (I4C)', International Journal of Cancer, bind 146, nr. 4, s. 943-952. https://doi.org/10.1002/ijc.32388

APA

Patel, D. M., Jones, R. R., Booth, B. J., Olsson, A. C., Kromhout, H., Straif, K., Vermeulen, R., Tikellis, G., Paltiel, O., Golding, J., Northstone, K., Stoltenberg, C., Håberg, S. E., Schüz, J., Friesen, M. C., Ponsonby, A. L., Lemeshow, S., Linet, M. S., Magnus, P., ... on behalf of the International Childhood Cancer Cohort Consortium (2020). Parental occupational exposure to pesticides, animals and organic dust and risk of childhood leukemia and central nervous system tumors: Findings from the International Childhood Cancer Cohort Consortium (I4C). International Journal of Cancer, 146(4), 943-952. https://doi.org/10.1002/ijc.32388

Vancouver

Patel DM, Jones RR, Booth BJ, Olsson AC, Kromhout H, Straif K o.a. Parental occupational exposure to pesticides, animals and organic dust and risk of childhood leukemia and central nervous system tumors: Findings from the International Childhood Cancer Cohort Consortium (I4C). International Journal of Cancer. 2020;146(4):943-952. https://doi.org/10.1002/ijc.32388

Author

Patel, Deven M. ; Jones, Rena R. ; Booth, Benjamin J. ; Olsson, Ann C. ; Kromhout, Hans ; Straif, Kurt ; Vermeulen, Roel ; Tikellis, Gabriella ; Paltiel, Ora ; Golding, Jean ; Northstone, Kate ; Stoltenberg, Camilla ; Håberg, Siri E. ; Schüz, Joachim ; Friesen, Melissa C. ; Ponsonby, Anne Louise ; Lemeshow, Stanley ; Linet, Martha S. ; Magnus, Per ; Olsen, Jørn ; Olsen, Sjurdur F. ; Dwyer, Terence ; Stayner, Leslie T. ; Ward, Mary H. ; on behalf of the International Childhood Cancer Cohort Consortium. / Parental occupational exposure to pesticides, animals and organic dust and risk of childhood leukemia and central nervous system tumors : Findings from the International Childhood Cancer Cohort Consortium (I4C). I: International Journal of Cancer. 2020 ; Bind 146, Nr. 4. s. 943-952.

Bibtex

@article{8204edf4b9914f8d9dc7938501e5b954,

title = "Parental occupational exposure to pesticides, animals and organic dust and risk of childhood leukemia and central nervous system tumors: Findings from the International Childhood Cancer Cohort Consortium (I4C)",

abstract = "Parental occupational exposures to pesticides, animals and organic dust have been associated with an increased risk of childhood cancer based mostly on case–control studies. We prospectively evaluated parental occupational exposures and risk of childhood leukemia and central nervous system (CNS) tumors in the International Childhood Cancer Cohort Consortium. We pooled data on 329,658 participants from birth cohorts in five countries (Australia, Denmark, Israel, Norway and United Kingdom). Parental occupational exposures during pregnancy were estimated by linking International Standard Classification of Occupations-1988 job codes to the ALOHA+ job exposure matrix. Risk of childhood (<15 years) acute lymphoblastic leukemia (ALL; n = 129), acute myeloid leukemia (AML; n = 31) and CNS tumors (n = 158) was estimated using Cox proportional hazards models to generate hazard ratios (HR) and 95% confidence intervals (CI). Paternal exposures to pesticides and animals were associated with increased risk of childhood AML (herbicides HR = 3.22, 95% CI = 0.97–10.68; insecticides HR = 2.86, 95% CI = 0.99–8.23; animals HR = 3.89, 95% CI = 1.18–12.90), but not ALL or CNS tumors. Paternal exposure to organic dust was positively associated with AML (HR = 2.38 95% CI = 1.12–5.07), inversely associated with ALL (HR = 0.55, 95% CI = 0.31–0.99) and not associated with CNS tumors. Low exposure prevalence precluded evaluation of maternal pesticide and animal exposures; we observed no significant associations with organic dust exposure. This first prospective analysis of pooled birth cohorts and parental occupational exposures provides evidence for paternal agricultural exposures as childhood AML risk factors. The different risks for childhood ALL associated with maternal and paternal organic dust exposures should be investigated further.",

keywords = "agricultural exposures, animals, childhood brain tumors, childhood cancer, childhood leukemia, organic dust, parental occupation, pesticides",

author = "Patel, {Deven M.} and Jones, {Rena R.} and Booth, {Benjamin J.} and Olsson, {Ann C.} and Hans Kromhout and Kurt Straif and Roel Vermeulen and Gabriella Tikellis and Ora Paltiel and Jean Golding and Kate Northstone and Camilla Stoltenberg and H{\aa}berg, {Siri E.} and Joachim Sch{\"u}z and Friesen, {Melissa C.} and Ponsonby, {Anne Louise} and Stanley Lemeshow and Linet, {Martha S.} and Per Magnus and J{\o}rn Olsen and Olsen, {Sjurdur F.} and Terence Dwyer and Stayner, {Leslie T.} and Ward, {Mary H.} and {on behalf of the International Childhood Cancer Cohort Consortium}",

note = "Publisher Copyright: {\textcopyright} 2019 UICC",

year = "2020",

doi = "10.1002/ijc.32388",

language = "English",

volume = "146",

pages = "943--952",

journal = "Acta - Unio Internationalis Contra Cancrum",

issn = "0898-6924",

publisher = "JohnWiley & Sons, Inc.",

number = "4",

}

RIS

TY - JOUR

T1 - Parental occupational exposure to pesticides, animals and organic dust and risk of childhood leukemia and central nervous system tumors

T2 - Findings from the International Childhood Cancer Cohort Consortium (I4C)

AU - Patel, Deven M.

AU - Jones, Rena R.

AU - Booth, Benjamin J.

AU - Olsson, Ann C.

AU - Kromhout, Hans

AU - Straif, Kurt

AU - Vermeulen, Roel

AU - Tikellis, Gabriella

AU - Paltiel, Ora

AU - Golding, Jean

AU - Northstone, Kate

AU - Stoltenberg, Camilla

AU - Håberg, Siri E.

AU - Schüz, Joachim

AU - Friesen, Melissa C.

AU - Ponsonby, Anne Louise

AU - Lemeshow, Stanley

AU - Linet, Martha S.

AU - Magnus, Per

AU - Olsen, Jørn

AU - Olsen, Sjurdur F.

AU - Dwyer, Terence

AU - Stayner, Leslie T.

AU - Ward, Mary H.

AU - on behalf of the International Childhood Cancer Cohort Consortium

PY - 2020

Y1 - 2020

N2 - Parental occupational exposures to pesticides, animals and organic dust have been associated with an increased risk of childhood cancer based mostly on case–control studies. We prospectively evaluated parental occupational exposures and risk of childhood leukemia and central nervous system (CNS) tumors in the International Childhood Cancer Cohort Consortium. We pooled data on 329,658 participants from birth cohorts in five countries (Australia, Denmark, Israel, Norway and United Kingdom). Parental occupational exposures during pregnancy were estimated by linking International Standard Classification of Occupations-1988 job codes to the ALOHA+ job exposure matrix. Risk of childhood (<15 years) acute lymphoblastic leukemia (ALL; n = 129), acute myeloid leukemia (AML; n = 31) and CNS tumors (n = 158) was estimated using Cox proportional hazards models to generate hazard ratios (HR) and 95% confidence intervals (CI). Paternal exposures to pesticides and animals were associated with increased risk of childhood AML (herbicides HR = 3.22, 95% CI = 0.97–10.68; insecticides HR = 2.86, 95% CI = 0.99–8.23; animals HR = 3.89, 95% CI = 1.18–12.90), but not ALL or CNS tumors. Paternal exposure to organic dust was positively associated with AML (HR = 2.38 95% CI = 1.12–5.07), inversely associated with ALL (HR = 0.55, 95% CI = 0.31–0.99) and not associated with CNS tumors. Low exposure prevalence precluded evaluation of maternal pesticide and animal exposures; we observed no significant associations with organic dust exposure. This first prospective analysis of pooled birth cohorts and parental occupational exposures provides evidence for paternal agricultural exposures as childhood AML risk factors. The different risks for childhood ALL associated with maternal and paternal organic dust exposures should be investigated further.

AB - Parental occupational exposures to pesticides, animals and organic dust have been associated with an increased risk of childhood cancer based mostly on case–control studies. We prospectively evaluated parental occupational exposures and risk of childhood leukemia and central nervous system (CNS) tumors in the International Childhood Cancer Cohort Consortium. We pooled data on 329,658 participants from birth cohorts in five countries (Australia, Denmark, Israel, Norway and United Kingdom). Parental occupational exposures during pregnancy were estimated by linking International Standard Classification of Occupations-1988 job codes to the ALOHA+ job exposure matrix. Risk of childhood (<15 years) acute lymphoblastic leukemia (ALL; n = 129), acute myeloid leukemia (AML; n = 31) and CNS tumors (n = 158) was estimated using Cox proportional hazards models to generate hazard ratios (HR) and 95% confidence intervals (CI). Paternal exposures to pesticides and animals were associated with increased risk of childhood AML (herbicides HR = 3.22, 95% CI = 0.97–10.68; insecticides HR = 2.86, 95% CI = 0.99–8.23; animals HR = 3.89, 95% CI = 1.18–12.90), but not ALL or CNS tumors. Paternal exposure to organic dust was positively associated with AML (HR = 2.38 95% CI = 1.12–5.07), inversely associated with ALL (HR = 0.55, 95% CI = 0.31–0.99) and not associated with CNS tumors. Low exposure prevalence precluded evaluation of maternal pesticide and animal exposures; we observed no significant associations with organic dust exposure. This first prospective analysis of pooled birth cohorts and parental occupational exposures provides evidence for paternal agricultural exposures as childhood AML risk factors. The different risks for childhood ALL associated with maternal and paternal organic dust exposures should be investigated further.

KW - agricultural exposures

KW - animals

KW - childhood brain tumors

KW - childhood cancer

KW - childhood leukemia

KW - organic dust

KW - parental occupation

KW - pesticides

U2 - 10.1002/ijc.32388

DO - 10.1002/ijc.32388

M3 - Journal article

C2 - 31054169

AN - SCOPUS:85066310161

VL - 146

SP - 943

EP - 952

JO - Acta - Unio Internationalis Contra Cancrum

JF - Acta - Unio Internationalis Contra Cancrum

SN - 0898-6924

IS - 4

ER -

ID: 291115146