Parental occupational exposure to pesticides, animals and organic dust and risk of childhood leukemia and central nervous system tumors: Findings from the International Childhood Cancer Cohort Consortium (I4C)
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
Parental occupational exposure to pesticides, animals and organic dust and risk of childhood leukemia and central nervous system tumors : Findings from the International Childhood Cancer Cohort Consortium (I4C). / Patel, Deven M.; Jones, Rena R.; Booth, Benjamin J.; Olsson, Ann C.; Kromhout, Hans; Straif, Kurt; Vermeulen, Roel; Tikellis, Gabriella; Paltiel, Ora; Golding, Jean; Northstone, Kate; Stoltenberg, Camilla; Håberg, Siri E.; Schüz, Joachim; Friesen, Melissa C.; Ponsonby, Anne Louise; Lemeshow, Stanley; Linet, Martha S.; Magnus, Per; Olsen, Jørn; Olsen, Sjurdur F.; Dwyer, Terence; Stayner, Leslie T.; Ward, Mary H.; on behalf of the International Childhood Cancer Cohort Consortium.
I: International Journal of Cancer, Bind 146, Nr. 4, 2020, s. 943-952.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Parental occupational exposure to pesticides, animals and organic dust and risk of childhood leukemia and central nervous system tumors
T2 - Findings from the International Childhood Cancer Cohort Consortium (I4C)
AU - Patel, Deven M.
AU - Jones, Rena R.
AU - Booth, Benjamin J.
AU - Olsson, Ann C.
AU - Kromhout, Hans
AU - Straif, Kurt
AU - Vermeulen, Roel
AU - Tikellis, Gabriella
AU - Paltiel, Ora
AU - Golding, Jean
AU - Northstone, Kate
AU - Stoltenberg, Camilla
AU - Håberg, Siri E.
AU - Schüz, Joachim
AU - Friesen, Melissa C.
AU - Ponsonby, Anne Louise
AU - Lemeshow, Stanley
AU - Linet, Martha S.
AU - Magnus, Per
AU - Olsen, Jørn
AU - Olsen, Sjurdur F.
AU - Dwyer, Terence
AU - Stayner, Leslie T.
AU - Ward, Mary H.
AU - on behalf of the International Childhood Cancer Cohort Consortium
N1 - Publisher Copyright: © 2019 UICC
PY - 2020
Y1 - 2020
N2 - Parental occupational exposures to pesticides, animals and organic dust have been associated with an increased risk of childhood cancer based mostly on case–control studies. We prospectively evaluated parental occupational exposures and risk of childhood leukemia and central nervous system (CNS) tumors in the International Childhood Cancer Cohort Consortium. We pooled data on 329,658 participants from birth cohorts in five countries (Australia, Denmark, Israel, Norway and United Kingdom). Parental occupational exposures during pregnancy were estimated by linking International Standard Classification of Occupations-1988 job codes to the ALOHA+ job exposure matrix. Risk of childhood (<15 years) acute lymphoblastic leukemia (ALL; n = 129), acute myeloid leukemia (AML; n = 31) and CNS tumors (n = 158) was estimated using Cox proportional hazards models to generate hazard ratios (HR) and 95% confidence intervals (CI). Paternal exposures to pesticides and animals were associated with increased risk of childhood AML (herbicides HR = 3.22, 95% CI = 0.97–10.68; insecticides HR = 2.86, 95% CI = 0.99–8.23; animals HR = 3.89, 95% CI = 1.18–12.90), but not ALL or CNS tumors. Paternal exposure to organic dust was positively associated with AML (HR = 2.38 95% CI = 1.12–5.07), inversely associated with ALL (HR = 0.55, 95% CI = 0.31–0.99) and not associated with CNS tumors. Low exposure prevalence precluded evaluation of maternal pesticide and animal exposures; we observed no significant associations with organic dust exposure. This first prospective analysis of pooled birth cohorts and parental occupational exposures provides evidence for paternal agricultural exposures as childhood AML risk factors. The different risks for childhood ALL associated with maternal and paternal organic dust exposures should be investigated further.
AB - Parental occupational exposures to pesticides, animals and organic dust have been associated with an increased risk of childhood cancer based mostly on case–control studies. We prospectively evaluated parental occupational exposures and risk of childhood leukemia and central nervous system (CNS) tumors in the International Childhood Cancer Cohort Consortium. We pooled data on 329,658 participants from birth cohorts in five countries (Australia, Denmark, Israel, Norway and United Kingdom). Parental occupational exposures during pregnancy were estimated by linking International Standard Classification of Occupations-1988 job codes to the ALOHA+ job exposure matrix. Risk of childhood (<15 years) acute lymphoblastic leukemia (ALL; n = 129), acute myeloid leukemia (AML; n = 31) and CNS tumors (n = 158) was estimated using Cox proportional hazards models to generate hazard ratios (HR) and 95% confidence intervals (CI). Paternal exposures to pesticides and animals were associated with increased risk of childhood AML (herbicides HR = 3.22, 95% CI = 0.97–10.68; insecticides HR = 2.86, 95% CI = 0.99–8.23; animals HR = 3.89, 95% CI = 1.18–12.90), but not ALL or CNS tumors. Paternal exposure to organic dust was positively associated with AML (HR = 2.38 95% CI = 1.12–5.07), inversely associated with ALL (HR = 0.55, 95% CI = 0.31–0.99) and not associated with CNS tumors. Low exposure prevalence precluded evaluation of maternal pesticide and animal exposures; we observed no significant associations with organic dust exposure. This first prospective analysis of pooled birth cohorts and parental occupational exposures provides evidence for paternal agricultural exposures as childhood AML risk factors. The different risks for childhood ALL associated with maternal and paternal organic dust exposures should be investigated further.
KW - agricultural exposures
KW - animals
KW - childhood brain tumors
KW - childhood cancer
KW - childhood leukemia
KW - organic dust
KW - parental occupation
KW - pesticides
U2 - 10.1002/ijc.32388
DO - 10.1002/ijc.32388
M3 - Journal article
C2 - 31054169
AN - SCOPUS:85066310161
VL - 146
SP - 943
EP - 952
JO - Acta - Unio Internationalis Contra Cancrum
JF - Acta - Unio Internationalis Contra Cancrum
SN - 0898-6924
IS - 4
ER -
ID: 291115146