TY - JOUR

T1 - Pain sensitivity in relation to frequency of migraine and tension-type headache with or without coexistent neck pain

T2 - an exploratory secondary analysis of the population study

AU - Ashina, Sait

AU - Bendtsen, Lars

AU - Burstein, Rami

AU - Iljazi, Afrim

AU - Jensen, Rigmor Hoejland

AU - Lipton, Richard B.

PY - 2023

Y1 - 2023

N2 - Objectives: We aimed to investigate whether coexistent self-reported neck pain influences cephalic and extracephalic pain sensitivity in individuals with migraine and tension-type headache (TTH) in relation to diagnosis and headache frequency.Methods: A population of 496 individuals completed a headache interview based on ICHD criteria, providing data collected by self-administered questionnaires, assessments of pericranial total tenderness score (TTS) and pressure pain thresholds (PPT). Stimulus-response (SR) functions for pressure vs. pain were recorded. Presence of neck pain in the past year was assessed by the self-administered questionnaire. We categorized participants by primary headache type. We also categorized participants into 3 groups by headache frequency: chronic (>= 15) or episodic (Results: Individuals with chronic followed by episodic headache had higher TTS than controls (overall 130.001). The difference between chronic and episodic headache subgroups was significant in the group with neck pain (130.001) but not in the group without neck pain. In individuals with neck pain, mean TTS was higher in coexistent headache (migraine and TTH), 23.2 +/- 10.7, and pure TTH, 17.8 +/- 10.3, compared to pure migraine, 15.9 +/- 10.9 and no headache 11.0 +/- 8.3 (overall pConclusions: Coexistent neck pain is associated with greater pericranial tenderness in individuals with chronic headache and to a lesser degree in those with episodic headache. Sensitization maybe a substrate or consequence of neck pain and primary headache, but a longitudinal study would be needed for further clarification.

AB - Objectives: We aimed to investigate whether coexistent self-reported neck pain influences cephalic and extracephalic pain sensitivity in individuals with migraine and tension-type headache (TTH) in relation to diagnosis and headache frequency.Methods: A population of 496 individuals completed a headache interview based on ICHD criteria, providing data collected by self-administered questionnaires, assessments of pericranial total tenderness score (TTS) and pressure pain thresholds (PPT). Stimulus-response (SR) functions for pressure vs. pain were recorded. Presence of neck pain in the past year was assessed by the self-administered questionnaire. We categorized participants by primary headache type. We also categorized participants into 3 groups by headache frequency: chronic (>= 15) or episodic (Results: Individuals with chronic followed by episodic headache had higher TTS than controls (overall 130.001). The difference between chronic and episodic headache subgroups was significant in the group with neck pain (130.001) but not in the group without neck pain. In individuals with neck pain, mean TTS was higher in coexistent headache (migraine and TTH), 23.2 +/- 10.7, and pure TTH, 17.8 +/- 10.3, compared to pure migraine, 15.9 +/- 10.9 and no headache 11.0 +/- 8.3 (overall pConclusions: Coexistent neck pain is associated with greater pericranial tenderness in individuals with chronic headache and to a lesser degree in those with episodic headache. Sensitization maybe a substrate or consequence of neck pain and primary headache, but a longitudinal study would be needed for further clarification.

KW - central sensitization

KW - comorbidity

KW - headache

KW - neck pain

KW - pain threshold

KW - peripheral sensitization

KW - population

KW - tenderness

KW - MYOFASCIAL TRIGGER POINTS

KW - MUSCLE TENDERNESS

KW - CENTRAL SENSITIZATION

KW - TEMPORAL REGION

KW - GLOBAL BURDEN

KW - PREVALENCE

KW - EPIDEMIOLOGY

KW - DISABILITY

KW - NOCICEPTION

KW - THRESHOLD

U2 - 10.1515/sjpain-2022-0030

DO - 10.1515/sjpain-2022-0030

M3 - Journal article

C2 - 36137215

VL - 23

SP - 76

EP - 87

JO - Scandinavian Journal of Pain

JF - Scandinavian Journal of Pain

SN - 1877-8860

IS - 1

ER -