Origins and mechanisms leading to aneuploidy in human eggs
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Dokumenter
- Origins and mechanisms leading to aneuploidy in human eggs
Forlagets udgivne version, 958 KB, PDF-dokument
The gain or loss of a chromosome—or aneuploidy—acts as one of the major triggers for infertility and pregnancy loss in humans. These chromosomal abnormalities affect more than 40% of eggs in women at both ends of the age spectrum, that is, young girls as well as women of advancing maternal age. Recent studies in human oocytes and embryos using genomics, cytogenetics, and in silico modeling all provide new insight into the rates and potential genetic and cellular factors associated with aneuploidy at varying stages of development. Here, we review recent studies that are shedding light on potential molecular mechanisms of chromosome missegregation in oocytes and embryos across the entire female reproductive life span.
Originalsprog | Engelsk |
---|---|
Tidsskrift | Prenatal Diagnosis |
Vol/bind | 41 |
Udgave nummer | 5 |
Sider (fra-til) | 620-630 |
ISSN | 0197-3851 |
DOI | |
Status | Udgivet - 2021 |
Antal downloads er baseret på statistik fra Google Scholar og www.ku.dk
Ingen data tilgængelig
ID: 258717452