Origins and mechanisms leading to aneuploidy in human eggs
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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Origins and mechanisms leading to aneuploidy in human eggs. / Wartosch, Lena; Schindler, Karen; Schuh, Melina; Gruhn, Jennifer R.; Hoffmann, Eva R.; Mccoy, Rajiv C.; Xing, Jinchuan.
I: Prenatal Diagnosis, Bind 41, Nr. 5, 2021, s. 620-630.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Origins and mechanisms leading to aneuploidy in human eggs
AU - Wartosch, Lena
AU - Schindler, Karen
AU - Schuh, Melina
AU - Gruhn, Jennifer R.
AU - Hoffmann, Eva R.
AU - Mccoy, Rajiv C.
AU - Xing, Jinchuan
PY - 2021
Y1 - 2021
N2 - The gain or loss of a chromosome—or aneuploidy—acts as one of the major triggers for infertility and pregnancy loss in humans. These chromosomal abnormalities affect more than 40% of eggs in women at both ends of the age spectrum, that is, young girls as well as women of advancing maternal age. Recent studies in human oocytes and embryos using genomics, cytogenetics, and in silico modeling all provide new insight into the rates and potential genetic and cellular factors associated with aneuploidy at varying stages of development. Here, we review recent studies that are shedding light on potential molecular mechanisms of chromosome missegregation in oocytes and embryos across the entire female reproductive life span.
AB - The gain or loss of a chromosome—or aneuploidy—acts as one of the major triggers for infertility and pregnancy loss in humans. These chromosomal abnormalities affect more than 40% of eggs in women at both ends of the age spectrum, that is, young girls as well as women of advancing maternal age. Recent studies in human oocytes and embryos using genomics, cytogenetics, and in silico modeling all provide new insight into the rates and potential genetic and cellular factors associated with aneuploidy at varying stages of development. Here, we review recent studies that are shedding light on potential molecular mechanisms of chromosome missegregation in oocytes and embryos across the entire female reproductive life span.
U2 - 10.1002/pd.5927
DO - 10.1002/pd.5927
M3 - Journal article
C2 - 33860956
VL - 41
SP - 620
EP - 630
JO - Prenatal Diagnosis
JF - Prenatal Diagnosis
SN - 0197-3851
IS - 5
ER -
ID: 258717452