Origins and mechanisms leading to aneuploidy in human eggs

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Standard

Origins and mechanisms leading to aneuploidy in human eggs. / Wartosch, Lena; Schindler, Karen; Schuh, Melina; Gruhn, Jennifer R.; Hoffmann, Eva R.; Mccoy, Rajiv C.; Xing, Jinchuan.

I: Prenatal Diagnosis, Bind 41, Nr. 5, 2021, s. 620-630.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Wartosch, L, Schindler, K, Schuh, M, Gruhn, JR, Hoffmann, ER, Mccoy, RC & Xing, J 2021, 'Origins and mechanisms leading to aneuploidy in human eggs', Prenatal Diagnosis, bind 41, nr. 5, s. 620-630. https://doi.org/10.1002/pd.5927

APA

Wartosch, L., Schindler, K., Schuh, M., Gruhn, J. R., Hoffmann, E. R., Mccoy, R. C., & Xing, J. (2021). Origins and mechanisms leading to aneuploidy in human eggs. Prenatal Diagnosis, 41(5), 620-630. https://doi.org/10.1002/pd.5927

Vancouver

Wartosch L, Schindler K, Schuh M, Gruhn JR, Hoffmann ER, Mccoy RC o.a. Origins and mechanisms leading to aneuploidy in human eggs. Prenatal Diagnosis. 2021;41(5):620-630. https://doi.org/10.1002/pd.5927

Author

Wartosch, Lena ; Schindler, Karen ; Schuh, Melina ; Gruhn, Jennifer R. ; Hoffmann, Eva R. ; Mccoy, Rajiv C. ; Xing, Jinchuan. / Origins and mechanisms leading to aneuploidy in human eggs. I: Prenatal Diagnosis. 2021 ; Bind 41, Nr. 5. s. 620-630.

Bibtex

@article{6861beadfdea4ec3aa03f3f62c2066df,
title = "Origins and mechanisms leading to aneuploidy in human eggs",
abstract = "The gain or loss of a chromosome—or aneuploidy—acts as one of the major triggers for infertility and pregnancy loss in humans. These chromosomal abnormalities affect more than 40% of eggs in women at both ends of the age spectrum, that is, young girls as well as women of advancing maternal age. Recent studies in human oocytes and embryos using genomics, cytogenetics, and in silico modeling all provide new insight into the rates and potential genetic and cellular factors associated with aneuploidy at varying stages of development. Here, we review recent studies that are shedding light on potential molecular mechanisms of chromosome missegregation in oocytes and embryos across the entire female reproductive life span.",
author = "Lena Wartosch and Karen Schindler and Melina Schuh and Gruhn, {Jennifer R.} and Hoffmann, {Eva R.} and Mccoy, {Rajiv C.} and Jinchuan Xing",
year = "2021",
doi = "10.1002/pd.5927",
language = "English",
volume = "41",
pages = "620--630",
journal = "Prenatal Diagnosis",
issn = "0197-3851",
publisher = "JohnWiley & Sons Ltd",
number = "5",

}

RIS

TY - JOUR

T1 - Origins and mechanisms leading to aneuploidy in human eggs

AU - Wartosch, Lena

AU - Schindler, Karen

AU - Schuh, Melina

AU - Gruhn, Jennifer R.

AU - Hoffmann, Eva R.

AU - Mccoy, Rajiv C.

AU - Xing, Jinchuan

PY - 2021

Y1 - 2021

N2 - The gain or loss of a chromosome—or aneuploidy—acts as one of the major triggers for infertility and pregnancy loss in humans. These chromosomal abnormalities affect more than 40% of eggs in women at both ends of the age spectrum, that is, young girls as well as women of advancing maternal age. Recent studies in human oocytes and embryos using genomics, cytogenetics, and in silico modeling all provide new insight into the rates and potential genetic and cellular factors associated with aneuploidy at varying stages of development. Here, we review recent studies that are shedding light on potential molecular mechanisms of chromosome missegregation in oocytes and embryos across the entire female reproductive life span.

AB - The gain or loss of a chromosome—or aneuploidy—acts as one of the major triggers for infertility and pregnancy loss in humans. These chromosomal abnormalities affect more than 40% of eggs in women at both ends of the age spectrum, that is, young girls as well as women of advancing maternal age. Recent studies in human oocytes and embryos using genomics, cytogenetics, and in silico modeling all provide new insight into the rates and potential genetic and cellular factors associated with aneuploidy at varying stages of development. Here, we review recent studies that are shedding light on potential molecular mechanisms of chromosome missegregation in oocytes and embryos across the entire female reproductive life span.

U2 - 10.1002/pd.5927

DO - 10.1002/pd.5927

M3 - Journal article

C2 - 33860956

VL - 41

SP - 620

EP - 630

JO - Prenatal Diagnosis

JF - Prenatal Diagnosis

SN - 0197-3851

IS - 5

ER -

ID: 258717452