Oral hypoglycaemic agents, insulin resistance and cardiovascular disease in patients with type 2 diabetes
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Oral hypoglycaemic agents, insulin resistance and cardiovascular disease in patients with type 2 diabetes. / Hemmingsen, Bianca; Lund, Søren S; Wetterslev, Jørn; Vaag, Allan.
I: European Journal of Endocrinology, Bind 161, Nr. 1, 2009, s. 1-9.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Oral hypoglycaemic agents, insulin resistance and cardiovascular disease in patients with type 2 diabetes
AU - Hemmingsen, Bianca
AU - Lund, Søren S
AU - Wetterslev, Jørn
AU - Vaag, Allan
N1 - Keywords: Administration, Oral; Animals; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Insulin Resistance; Prevalence; Risk Factors Export Date: 4 November 2009Source: Scopus
PY - 2009
Y1 - 2009
N2 - This article is a narrative review of the current evidence of the effects on cardiovascular disease (CVD) of oral hypoglycaemic agents that increase insulin sensitivity in patients with type 2 diabetes (T2D). In overweight T2D patients, metformin has been demonstrated to reduce CVD risk, and this beneficial effect may be conserved with the combination of metformin and insulin treatment. However, the effect of glitazones on CVD is uncertain. There is conflicting evidence from large randomized trials to support a protective effect against CVD of lowering blood glucose per se but a systematic review with meta-analysis is lacking. It may be reasonable to aim for an intervention targeting multiple CVD risk factors such as dyslipidaemia, hypertension and albuminuria in T2D patients.
AB - This article is a narrative review of the current evidence of the effects on cardiovascular disease (CVD) of oral hypoglycaemic agents that increase insulin sensitivity in patients with type 2 diabetes (T2D). In overweight T2D patients, metformin has been demonstrated to reduce CVD risk, and this beneficial effect may be conserved with the combination of metformin and insulin treatment. However, the effect of glitazones on CVD is uncertain. There is conflicting evidence from large randomized trials to support a protective effect against CVD of lowering blood glucose per se but a systematic review with meta-analysis is lacking. It may be reasonable to aim for an intervention targeting multiple CVD risk factors such as dyslipidaemia, hypertension and albuminuria in T2D patients.
U2 - 10.1530/EJE-09-0167
DO - 10.1530/EJE-09-0167
M3 - Journal article
C2 - 19369429
VL - 161
SP - 1
EP - 9
JO - European Journal of Endocrinology
JF - European Journal of Endocrinology
SN - 0804-4643
IS - 1
ER -
ID: 19979293