One day of overfeeding impairs nocturnal glucose but not fatty acid homeostasis in overweight men

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Standard

One day of overfeeding impairs nocturnal glucose but not fatty acid homeostasis in overweight men. / Magkos, Faidon; Smith, Gordon I; Reeds, Dominic N; Okunade, Adewole; Patterson, Bruce W; Mittendorfer, Bettina.

I: Obesity, Bind 22, Nr. 2, 2014, s. 435-440.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Magkos, F, Smith, GI, Reeds, DN, Okunade, A, Patterson, BW & Mittendorfer, B 2014, 'One day of overfeeding impairs nocturnal glucose but not fatty acid homeostasis in overweight men', Obesity, bind 22, nr. 2, s. 435-440. https://doi.org/10.1002/oby.20562

APA

Magkos, F., Smith, G. I., Reeds, D. N., Okunade, A., Patterson, B. W., & Mittendorfer, B. (2014). One day of overfeeding impairs nocturnal glucose but not fatty acid homeostasis in overweight men. Obesity, 22(2), 435-440. https://doi.org/10.1002/oby.20562

Vancouver

Magkos F, Smith GI, Reeds DN, Okunade A, Patterson BW, Mittendorfer B. One day of overfeeding impairs nocturnal glucose but not fatty acid homeostasis in overweight men. Obesity. 2014;22(2):435-440. https://doi.org/10.1002/oby.20562

Author

Magkos, Faidon ; Smith, Gordon I ; Reeds, Dominic N ; Okunade, Adewole ; Patterson, Bruce W ; Mittendorfer, Bettina. / One day of overfeeding impairs nocturnal glucose but not fatty acid homeostasis in overweight men. I: Obesity. 2014 ; Bind 22, Nr. 2. s. 435-440.

Bibtex

@article{5c6d0c402b014e1d953b11f233a17351,
title = "One day of overfeeding impairs nocturnal glucose but not fatty acid homeostasis in overweight men",
abstract = "Objective: Overfeeding is associated with insulin resistance. Studies on animals suggest this is likely due to disruption of fatty acid metabolism and increased plasma free fatty acid (FFA) availability during the night. We tested the hypothesis that overfeeding induces insulin resistance and increases nocturnal but not daytime plasma FFA availability in human subjects.Design and methods: We measured plasma glucose, insulin, and FFA concentrations hourly for 24 h during a day of isocaloric feeding and a day of hypercaloric feeding (30% calorie excess) in 8 overweight and obese, nondiabetic men (age: 38±3 years; body mass index: 34±2 kg/m²).Results: Overfeeding had no effect on daytime plasma glucose, insulin, and FFA concentrations compared to isocaloric feeding, but increased nocturnal glucose (P = 0.007) and insulin (P = 0.003) concentrations and decreased nocturnal FFA concentration (P = 0.006). The homeostasis model assessment of insulin resistance score was ∼30% greater the morning after hypercaloric than isocaloric feeding (P = 0.040).Conclusions: One day of overfeeding has no effect on daytime plasma glucose and FFA concentrations but increases nocturnal plasma glucose and insulin concentrations, whereas nocturnal plasma FFA availability is reduced. The acute overfeeding-induced development of insulin resistant glucose metabolism therefore does not appear to be directly mediated by plasma FFA availability.",
keywords = "Adipose Tissue/metabolism, Adult, Allostasis, Blood Glucose, Body Mass Index, Circadian Rhythm, Fatty Acids, Nonesterified/blood, Homeostasis, Humans, Hyperglycemia/etiology, Hyperinsulinism/etiology, Hyperphagia/blood, Insulin/blood, Insulin Resistance, Liver/metabolism, Male, Muscles/metabolism, Obesity/blood, Overweight/blood, Snacks",
author = "Faidon Magkos and Smith, {Gordon I} and Reeds, {Dominic N} and Adewole Okunade and Patterson, {Bruce W} and Bettina Mittendorfer",
note = "Copyright {\textcopyright} 2013 The Obesity Society.",
year = "2014",
doi = "10.1002/oby.20562",
language = "English",
volume = "22",
pages = "435--440",
journal = "Obesity",
issn = "1930-7381",
publisher = "Wiley-Blackwell",
number = "2",

}

RIS

TY - JOUR

T1 - One day of overfeeding impairs nocturnal glucose but not fatty acid homeostasis in overweight men

AU - Magkos, Faidon

AU - Smith, Gordon I

AU - Reeds, Dominic N

AU - Okunade, Adewole

AU - Patterson, Bruce W

AU - Mittendorfer, Bettina

N1 - Copyright © 2013 The Obesity Society.

PY - 2014

Y1 - 2014

N2 - Objective: Overfeeding is associated with insulin resistance. Studies on animals suggest this is likely due to disruption of fatty acid metabolism and increased plasma free fatty acid (FFA) availability during the night. We tested the hypothesis that overfeeding induces insulin resistance and increases nocturnal but not daytime plasma FFA availability in human subjects.Design and methods: We measured plasma glucose, insulin, and FFA concentrations hourly for 24 h during a day of isocaloric feeding and a day of hypercaloric feeding (30% calorie excess) in 8 overweight and obese, nondiabetic men (age: 38±3 years; body mass index: 34±2 kg/m²).Results: Overfeeding had no effect on daytime plasma glucose, insulin, and FFA concentrations compared to isocaloric feeding, but increased nocturnal glucose (P = 0.007) and insulin (P = 0.003) concentrations and decreased nocturnal FFA concentration (P = 0.006). The homeostasis model assessment of insulin resistance score was ∼30% greater the morning after hypercaloric than isocaloric feeding (P = 0.040).Conclusions: One day of overfeeding has no effect on daytime plasma glucose and FFA concentrations but increases nocturnal plasma glucose and insulin concentrations, whereas nocturnal plasma FFA availability is reduced. The acute overfeeding-induced development of insulin resistant glucose metabolism therefore does not appear to be directly mediated by plasma FFA availability.

AB - Objective: Overfeeding is associated with insulin resistance. Studies on animals suggest this is likely due to disruption of fatty acid metabolism and increased plasma free fatty acid (FFA) availability during the night. We tested the hypothesis that overfeeding induces insulin resistance and increases nocturnal but not daytime plasma FFA availability in human subjects.Design and methods: We measured plasma glucose, insulin, and FFA concentrations hourly for 24 h during a day of isocaloric feeding and a day of hypercaloric feeding (30% calorie excess) in 8 overweight and obese, nondiabetic men (age: 38±3 years; body mass index: 34±2 kg/m²).Results: Overfeeding had no effect on daytime plasma glucose, insulin, and FFA concentrations compared to isocaloric feeding, but increased nocturnal glucose (P = 0.007) and insulin (P = 0.003) concentrations and decreased nocturnal FFA concentration (P = 0.006). The homeostasis model assessment of insulin resistance score was ∼30% greater the morning after hypercaloric than isocaloric feeding (P = 0.040).Conclusions: One day of overfeeding has no effect on daytime plasma glucose and FFA concentrations but increases nocturnal plasma glucose and insulin concentrations, whereas nocturnal plasma FFA availability is reduced. The acute overfeeding-induced development of insulin resistant glucose metabolism therefore does not appear to be directly mediated by plasma FFA availability.

KW - Adipose Tissue/metabolism

KW - Adult

KW - Allostasis

KW - Blood Glucose

KW - Body Mass Index

KW - Circadian Rhythm

KW - Fatty Acids, Nonesterified/blood

KW - Homeostasis

KW - Humans

KW - Hyperglycemia/etiology

KW - Hyperinsulinism/etiology

KW - Hyperphagia/blood

KW - Insulin/blood

KW - Insulin Resistance

KW - Liver/metabolism

KW - Male

KW - Muscles/metabolism

KW - Obesity/blood

KW - Overweight/blood

KW - Snacks

U2 - 10.1002/oby.20562

DO - 10.1002/oby.20562

M3 - Journal article

C2 - 23836730

VL - 22

SP - 435

EP - 440

JO - Obesity

JF - Obesity

SN - 1930-7381

IS - 2

ER -

ID: 289966258