'One bead two compound libraries' for detecting chemical and biochemical conversions
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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'One bead two compound libraries' for detecting chemical and biochemical conversions. / Meldal, Morten.
I: Current Opinion in Chemical Biology, Bind 8, Nr. 3, 06.2004, s. 238-244.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - 'One bead two compound libraries' for detecting chemical and biochemical conversions
AU - Meldal, Morten
PY - 2004/6
Y1 - 2004/6
N2 - When combinatorial chemistry was introduced 13 years ago, the expectations were high for the delivery of results, particularly in the pharmaceutical industry. However, combinatorial chemistry was implemented independently of the application for which the products were going to be used. Resins developed only for efficient solid-phase synthesis were used and products were employed in existing assays developed for traditional solution studies. There was almost no assay or technology development and the use of real combinatorial methods soon had to give way to high-throughput synthesis and traditional screening. However, during recent years more sophisticated resins and assay techniques have been developed that may result in a second and more successful inplementation of real integrated combinatorial chemistry. The first in this line of new developments is the 'one bead two compound' assay, in which the resin bead in addition to a combinatorial library member contains a reporter compound that can act as a beacon to monitor the activity of the library member. This powerful concept can be generally applied in all fields of combinatorial chemistry including drug, catalysts and material development.
AB - When combinatorial chemistry was introduced 13 years ago, the expectations were high for the delivery of results, particularly in the pharmaceutical industry. However, combinatorial chemistry was implemented independently of the application for which the products were going to be used. Resins developed only for efficient solid-phase synthesis were used and products were employed in existing assays developed for traditional solution studies. There was almost no assay or technology development and the use of real combinatorial methods soon had to give way to high-throughput synthesis and traditional screening. However, during recent years more sophisticated resins and assay techniques have been developed that may result in a second and more successful inplementation of real integrated combinatorial chemistry. The first in this line of new developments is the 'one bead two compound' assay, in which the resin bead in addition to a combinatorial library member contains a reporter compound that can act as a beacon to monitor the activity of the library member. This powerful concept can be generally applied in all fields of combinatorial chemistry including drug, catalysts and material development.
KW - dimethoxy-trityl
KW - DMT
UR - http://www.scopus.com/inward/record.url?scp=2942555084&partnerID=8YFLogxK
U2 - 10.1016/j.cbpa.2004.04.007
DO - 10.1016/j.cbpa.2004.04.007
M3 - Review
C2 - 15183321
AN - SCOPUS:2942555084
VL - 8
SP - 238
EP - 244
JO - Current Opinion in Chemical Biology
JF - Current Opinion in Chemical Biology
SN - 1367-5931
IS - 3
ER -
ID: 327947990