Once in a lifetime: strategies for preventing re-replication in prokaryotic and eukaryotic cells.
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Once in a lifetime : strategies for preventing re-replication in prokaryotic and eukaryotic cells. / Nielsen, Olaf; Løbner-Olesen, Anders.
I: EMBO Reports, Bind 9, Nr. 2, 2008, s. 151-156.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Once in a lifetime
T2 - strategies for preventing re-replication in prokaryotic and eukaryotic cells.
AU - Nielsen, Olaf
AU - Løbner-Olesen, Anders
N1 - Keywords: DNA Replication; Escherichia coli; Eukaryotic Cells; Nucleotides; Prokaryotic Cells; Schizosaccharomyces
PY - 2008
Y1 - 2008
N2 - DNA replication is an extremely accurate process and cells have evolved intricate control mechanisms to ensure that each region of their genome is replicated only once during S phase. Here, we compare what is known about the processes that prevent re-replication in prokaryotic and eukaryotic cells by using the model organisms Escherichia coli and Schizosaccharomyces pombe as examples. Although the underlying molecular details are different, the logic behind the control mechanisms is similar. For example, after initiation, crucial molecules required for the loading of replicative helicases in both prokaryotes and eukaryotes are inactivated until the next cell cycle. Furthermore, in both systems the beta-clamp of the replicative polymerase associates with enzymatic activities that contribute to the inactivation of the helicase loaders. Finally, recent studies suggest that the control mechanism that prevents re-replication in both systems also increases the synthesis of DNA building blocks.
AB - DNA replication is an extremely accurate process and cells have evolved intricate control mechanisms to ensure that each region of their genome is replicated only once during S phase. Here, we compare what is known about the processes that prevent re-replication in prokaryotic and eukaryotic cells by using the model organisms Escherichia coli and Schizosaccharomyces pombe as examples. Although the underlying molecular details are different, the logic behind the control mechanisms is similar. For example, after initiation, crucial molecules required for the loading of replicative helicases in both prokaryotes and eukaryotes are inactivated until the next cell cycle. Furthermore, in both systems the beta-clamp of the replicative polymerase associates with enzymatic activities that contribute to the inactivation of the helicase loaders. Finally, recent studies suggest that the control mechanism that prevents re-replication in both systems also increases the synthesis of DNA building blocks.
U2 - 10.1038/sj.embor.2008.2
DO - 10.1038/sj.embor.2008.2
M3 - Review
C2 - 18246107
VL - 9
SP - 151
EP - 156
JO - E M B O Reports
JF - E M B O Reports
SN - 1469-221X
IS - 2
ER -
ID: 5626518