Olfactory dysfunction in aging and neurodegenerative diseases
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Olfactory dysfunction in aging and neurodegenerative diseases. / Dan, Xiuli; Wechter, Noah; Gray, Samuel; Mohanty, Joy G.; Croteau, Deborah L.; Bohr, Vilhelm A.
I: Ageing Research Reviews, Bind 70, 101416, 2021.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Olfactory dysfunction in aging and neurodegenerative diseases
AU - Dan, Xiuli
AU - Wechter, Noah
AU - Gray, Samuel
AU - Mohanty, Joy G.
AU - Croteau, Deborah L.
AU - Bohr, Vilhelm A.
N1 - Publisher Copyright: © 2021
PY - 2021
Y1 - 2021
N2 - Alterations in olfactory functions are proposed to be early biomarkers for neurodegeneration. Many neurodegenerative diseases are age-related, including two of the most common, Parkinson's disease (PD) and Alzheimer's disease (AD). The establishment of biomarkers that promote early risk identification is critical for the implementation of early treatment to postpone or avert pathological development. Olfactory dysfunction (OD) is seen in 90% of early-stage PD patients and 85% of patients with early-stage AD, which makes it an attractive biomarker for early diagnosis of these diseases. Here, we systematically review widely applied smelling tests available for humans as well as olfaction assessments performed in some animal models and the relationships between OD and normal aging, PD, AD, and other conditions. The utility of OD as a biomarker for neurodegenerative disease diagnosis and future research directions are also discussed.
AB - Alterations in olfactory functions are proposed to be early biomarkers for neurodegeneration. Many neurodegenerative diseases are age-related, including two of the most common, Parkinson's disease (PD) and Alzheimer's disease (AD). The establishment of biomarkers that promote early risk identification is critical for the implementation of early treatment to postpone or avert pathological development. Olfactory dysfunction (OD) is seen in 90% of early-stage PD patients and 85% of patients with early-stage AD, which makes it an attractive biomarker for early diagnosis of these diseases. Here, we systematically review widely applied smelling tests available for humans as well as olfaction assessments performed in some animal models and the relationships between OD and normal aging, PD, AD, and other conditions. The utility of OD as a biomarker for neurodegenerative disease diagnosis and future research directions are also discussed.
KW - Aging
KW - Alzheimer's disease
KW - Neurodegeneration
KW - Olfactory dysfunction
KW - Parkinson's disease
U2 - 10.1016/j.arr.2021.101416
DO - 10.1016/j.arr.2021.101416
M3 - Review
C2 - 34325072
AN - SCOPUS:85111478005
VL - 70
JO - Ageing Research Reviews
JF - Ageing Research Reviews
SN - 1568-1637
M1 - 101416
ER -
ID: 306972272