Olfactomedin 4 defines a subset of human neutrophils

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Standard

Olfactomedin 4 defines a subset of human neutrophils. / Clemmensen, Stine N; Bohr, Christina T; Rørvig, Sara; Glenthøj, Andreas; Mora-Jensen, Helena; Cramer, Elisabeth P; Jacobsen, Lars C; Larsen, Maria T; Cowland, Jack B; Tanassi, Julia T; Heegaard, Niels H H; Wren, Jonathan D; Silahtaroglu, Asli N; Borregaard, Niels.

I: Journal of Leukocyte Biology, Bind 91, Nr. 3, 03.2012, s. 495-500.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Clemmensen, SN, Bohr, CT, Rørvig, S, Glenthøj, A, Mora-Jensen, H, Cramer, EP, Jacobsen, LC, Larsen, MT, Cowland, JB, Tanassi, JT, Heegaard, NHH, Wren, JD, Silahtaroglu, AN & Borregaard, N 2012, 'Olfactomedin 4 defines a subset of human neutrophils', Journal of Leukocyte Biology, bind 91, nr. 3, s. 495-500. https://doi.org/10.1189/jlb.0811417

APA

Clemmensen, S. N., Bohr, C. T., Rørvig, S., Glenthøj, A., Mora-Jensen, H., Cramer, E. P., Jacobsen, L. C., Larsen, M. T., Cowland, J. B., Tanassi, J. T., Heegaard, N. H. H., Wren, J. D., Silahtaroglu, A. N., & Borregaard, N. (2012). Olfactomedin 4 defines a subset of human neutrophils. Journal of Leukocyte Biology, 91(3), 495-500. https://doi.org/10.1189/jlb.0811417

Vancouver

Clemmensen SN, Bohr CT, Rørvig S, Glenthøj A, Mora-Jensen H, Cramer EP o.a. Olfactomedin 4 defines a subset of human neutrophils. Journal of Leukocyte Biology. 2012 mar.;91(3):495-500. https://doi.org/10.1189/jlb.0811417

Author

Clemmensen, Stine N ; Bohr, Christina T ; Rørvig, Sara ; Glenthøj, Andreas ; Mora-Jensen, Helena ; Cramer, Elisabeth P ; Jacobsen, Lars C ; Larsen, Maria T ; Cowland, Jack B ; Tanassi, Julia T ; Heegaard, Niels H H ; Wren, Jonathan D ; Silahtaroglu, Asli N ; Borregaard, Niels. / Olfactomedin 4 defines a subset of human neutrophils. I: Journal of Leukocyte Biology. 2012 ; Bind 91, Nr. 3. s. 495-500.

Bibtex

@article{211d75bbbdf74cb7849caa2eb0a2c48f,
title = "Olfactomedin 4 defines a subset of human neutrophils",
abstract = "OLFM4 was identified initially as a gene highly induced in myeloid stem cells by G-CSF treatment. A bioinformatics method using a global meta-analysis of microarray data predicted that OLFM4 would be associated with specific granules in human neutrophils. Subcellular fractionation of peripheral blood neutrophils demonstrated complete colocalization of OLFM4 with the specific granule protein NGAL, and stimulation of neutrophils with PMA resulted in corelease of NGAL and OLFM4, proving that OLFM4 is a genuine constituent of neutrophil-specific granules. In accordance with this, OLFM4 mRNA peaked at the MY/MM stage of maturation. OLFM4 was, however, present in only 20-25% of peripheral blood neutrophils, as determined by immunocytochemistry and flow cytometry, whereas mRNA for OLFM4 was present in all MY/MM, indicating post-transcriptional regulation as a basis for the heterogeneous expression of OLFM4 protein.",
keywords = "Bone Marrow Cells, Cell Differentiation, Granulocyte Colony-Stimulating Factor, Humans, Myeloid Cells, Neutrophils, Protein Transport, RNA, Messenger",
author = "Clemmensen, {Stine N} and Bohr, {Christina T} and Sara R{\o}rvig and Andreas Glenth{\o}j and Helena Mora-Jensen and Cramer, {Elisabeth P} and Jacobsen, {Lars C} and Larsen, {Maria T} and Cowland, {Jack B} and Tanassi, {Julia T} and Heegaard, {Niels H H} and Wren, {Jonathan D} and Silahtaroglu, {Asli N} and Niels Borregaard",
year = "2012",
month = mar,
doi = "10.1189/jlb.0811417",
language = "English",
volume = "91",
pages = "495--500",
journal = "Journal of Leukocyte Biology",
issn = "0741-5400",
publisher = "Federation of American Societies for Experimental Biology",
number = "3",

}

RIS

TY - JOUR

T1 - Olfactomedin 4 defines a subset of human neutrophils

AU - Clemmensen, Stine N

AU - Bohr, Christina T

AU - Rørvig, Sara

AU - Glenthøj, Andreas

AU - Mora-Jensen, Helena

AU - Cramer, Elisabeth P

AU - Jacobsen, Lars C

AU - Larsen, Maria T

AU - Cowland, Jack B

AU - Tanassi, Julia T

AU - Heegaard, Niels H H

AU - Wren, Jonathan D

AU - Silahtaroglu, Asli N

AU - Borregaard, Niels

PY - 2012/3

Y1 - 2012/3

N2 - OLFM4 was identified initially as a gene highly induced in myeloid stem cells by G-CSF treatment. A bioinformatics method using a global meta-analysis of microarray data predicted that OLFM4 would be associated with specific granules in human neutrophils. Subcellular fractionation of peripheral blood neutrophils demonstrated complete colocalization of OLFM4 with the specific granule protein NGAL, and stimulation of neutrophils with PMA resulted in corelease of NGAL and OLFM4, proving that OLFM4 is a genuine constituent of neutrophil-specific granules. In accordance with this, OLFM4 mRNA peaked at the MY/MM stage of maturation. OLFM4 was, however, present in only 20-25% of peripheral blood neutrophils, as determined by immunocytochemistry and flow cytometry, whereas mRNA for OLFM4 was present in all MY/MM, indicating post-transcriptional regulation as a basis for the heterogeneous expression of OLFM4 protein.

AB - OLFM4 was identified initially as a gene highly induced in myeloid stem cells by G-CSF treatment. A bioinformatics method using a global meta-analysis of microarray data predicted that OLFM4 would be associated with specific granules in human neutrophils. Subcellular fractionation of peripheral blood neutrophils demonstrated complete colocalization of OLFM4 with the specific granule protein NGAL, and stimulation of neutrophils with PMA resulted in corelease of NGAL and OLFM4, proving that OLFM4 is a genuine constituent of neutrophil-specific granules. In accordance with this, OLFM4 mRNA peaked at the MY/MM stage of maturation. OLFM4 was, however, present in only 20-25% of peripheral blood neutrophils, as determined by immunocytochemistry and flow cytometry, whereas mRNA for OLFM4 was present in all MY/MM, indicating post-transcriptional regulation as a basis for the heterogeneous expression of OLFM4 protein.

KW - Bone Marrow Cells

KW - Cell Differentiation

KW - Granulocyte Colony-Stimulating Factor

KW - Humans

KW - Myeloid Cells

KW - Neutrophils

KW - Protein Transport

KW - RNA, Messenger

U2 - 10.1189/jlb.0811417

DO - 10.1189/jlb.0811417

M3 - Journal article

C2 - 22187488

VL - 91

SP - 495

EP - 500

JO - Journal of Leukocyte Biology

JF - Journal of Leukocyte Biology

SN - 0741-5400

IS - 3

ER -

ID: 38062653