Occupational exposure to respirable crystalline silica and incident idiopathic interstitial pneumonias and pulmonary sarcoidosis: a national prospective followup study
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Occupational exposure to respirable crystalline silica and incident idiopathic interstitial pneumonias and pulmonary sarcoidosis : a national prospective followup study. / Iversen, Inge Brosbøl; Vestergaard, Jesper Medom; Ohlander, Johan; Peters, Susan; Bendstrup, Elisabeth; Bonde, Jens Peter Ellekilde; Schlünssen, Vivi; Bønløkke, Jakob Hjort; Rasmussen, Finn; Stokholm, Zara Ann; Andersen, Michael Brun; Kromhout, Hans; Kolstad, Henrik Albert.
I: Occupational and Environmental Medicine, Bind 81, Nr. 6, 2024, s. 279-286.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Occupational exposure to respirable crystalline silica and incident idiopathic interstitial pneumonias and pulmonary sarcoidosis
T2 - a national prospective followup study
AU - Iversen, Inge Brosbøl
AU - Vestergaard, Jesper Medom
AU - Ohlander, Johan
AU - Peters, Susan
AU - Bendstrup, Elisabeth
AU - Bonde, Jens Peter Ellekilde
AU - Schlünssen, Vivi
AU - Bønløkke, Jakob Hjort
AU - Rasmussen, Finn
AU - Stokholm, Zara Ann
AU - Andersen, Michael Brun
AU - Kromhout, Hans
AU - Kolstad, Henrik Albert
N1 - Publisher Copyright: © Author(s) (or their employer(s)) 2024.
PY - 2024
Y1 - 2024
N2 - Background Respirable crystalline silica is a well-known cause of silicosis but may also be associated with other types of interstitial lung disease. We examined the associations between occupational exposure to respirable crystalline silica and the risk of idiopathic interstitial pneumonias, pulmonary sarcoidosis and silicosis. Methods The total Danish working population was followed 1977–2015. Annual individual exposure to respirable crystalline silica was estimated using a quantitative job exposure matrix. Cases were identified in the Danish National Patient Register. We conducted adjusted analyses of exposure–response relations between cumulative silica exposure and other exposure metrics and idiopathic interstitial pneumonias, pulmonary sarcoidosis and silicosis. Results Mean cumulative exposure was 125 µg/m3years among exposed workers. We observed increasing incidence rate ratios with increasing cumulative silica exposure for idiopathic interstitial pneumonias, pulmonary sarcoidosis and silicosis. For idiopathic interstitial pneumonias and pulmonary sarcoidosis, trends per 50 µg/m3-years were 1.03 (95% CI 1.02 to 1.03) and 1.06 (95% CI 1.04 to 1.07), respectively. For silicosis, we observed the well-known exposure–response relation with a trend per 50 µg/m3-years of 1.20 (95% CI 1.17 to 1.23). Conclusion This study suggests that silica inhalation may be related to pulmonary sarcoidosis and idiopathic interstitial pneumonias, though these findings may to some extent be explained by diagnostic misclassification. The observed exposure–response relations for silicosis at lower cumulative exposure levels than previously reported need to be corroborated in analyses that address the limitations of this study.
AB - Background Respirable crystalline silica is a well-known cause of silicosis but may also be associated with other types of interstitial lung disease. We examined the associations between occupational exposure to respirable crystalline silica and the risk of idiopathic interstitial pneumonias, pulmonary sarcoidosis and silicosis. Methods The total Danish working population was followed 1977–2015. Annual individual exposure to respirable crystalline silica was estimated using a quantitative job exposure matrix. Cases were identified in the Danish National Patient Register. We conducted adjusted analyses of exposure–response relations between cumulative silica exposure and other exposure metrics and idiopathic interstitial pneumonias, pulmonary sarcoidosis and silicosis. Results Mean cumulative exposure was 125 µg/m3years among exposed workers. We observed increasing incidence rate ratios with increasing cumulative silica exposure for idiopathic interstitial pneumonias, pulmonary sarcoidosis and silicosis. For idiopathic interstitial pneumonias and pulmonary sarcoidosis, trends per 50 µg/m3-years were 1.03 (95% CI 1.02 to 1.03) and 1.06 (95% CI 1.04 to 1.07), respectively. For silicosis, we observed the well-known exposure–response relation with a trend per 50 µg/m3-years of 1.20 (95% CI 1.17 to 1.23). Conclusion This study suggests that silica inhalation may be related to pulmonary sarcoidosis and idiopathic interstitial pneumonias, though these findings may to some extent be explained by diagnostic misclassification. The observed exposure–response relations for silicosis at lower cumulative exposure levels than previously reported need to be corroborated in analyses that address the limitations of this study.
U2 - 10.1136/oemed-2023-108964
DO - 10.1136/oemed-2023-108964
M3 - Journal article
C2 - 38902031
AN - SCOPUS:85197297731
VL - 81
SP - 279
EP - 286
JO - Occupational and Environmental Medicine
JF - Occupational and Environmental Medicine
SN - 1351-0711
IS - 6
ER -
ID: 397801064