Obesity is Associated With Increased Risk of Crohn's disease, but not Ulcerative Colitis

Obesity is Associated With Increased Risk of Crohn's disease, but not Ulcerative Colitis: A Pooled Analysis of Five Prospective Cohort Studies

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Standard

Obesity is Associated With Increased Risk of Crohn's disease, but not Ulcerative Colitis : A Pooled Analysis of Five Prospective Cohort Studies. / Chan, Simon S.M.; Chen, Ye; Casey, Kevin; Olen, Ola; Ludvigsson, Jonas F.; Carbonnel, Franck; Oldenburg, Bas; Gunter, Marc J.; Tjønneland, Anne; Grip, Olof; Amian, Pilar; Barricarte, Aurelio; Bergmann, Manuela M.; Boutron-Ruault, Marie Christine; Cross, Amanda; Hart, Andrew R.; Kaaks, Rudolf; Key, Tim; Chirlaque López, María Dolores; Robert Luben, Luben; Masala, Giovanna; Manjer, Jonas; Olsen, Anja; Overvad, Kim; Palli, Domenico; Riboli, Elio; Sánchez, Maria José; Tumino, Rosario; Vermeulen, Roel; Verschuren, W. M.Monique; Wareham, Nick; Ananthakrishnan, Ashwin; Burke, Kristin; Lopes, Emily Walsh; Richter, James; Lochhead, Paul; Chan, Andrew T.; Wolk, Alicia; Khalili, Hamed; DEFINe-IBD Investigators.

I: Clinical Gastroenterology and Hepatology, 2022, s. 1048-1058.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Chan, SSM, Chen, Y, Casey, K, Olen, O, Ludvigsson, JF, Carbonnel, F, Oldenburg, B, Gunter, MJ, Tjønneland, A, Grip, O, Amian, P, Barricarte, A, Bergmann, MM, Boutron-Ruault, MC, Cross, A, Hart, AR, Kaaks, R, Key, T, Chirlaque López, MD, Robert Luben, L, Masala, G, Manjer, J, Olsen, A, Overvad, K, Palli, D, Riboli, E, Sánchez, MJ, Tumino, R, Vermeulen, R, Verschuren, WMM, Wareham, N, Ananthakrishnan, A, Burke, K, Lopes, EW, Richter, J, Lochhead, P, Chan, AT, Wolk, A, Khalili, H & DEFINe-IBD Investigators 2022, 'Obesity is Associated With Increased Risk of Crohn's disease, but not Ulcerative Colitis: A Pooled Analysis of Five Prospective Cohort Studies', Clinical Gastroenterology and Hepatology, s. 1048-1058. https://doi.org/10.1016/j.cgh.2021.06.049

APA

Chan, S. S. M., Chen, Y., Casey, K., Olen, O., Ludvigsson, J. F., Carbonnel, F., Oldenburg, B., Gunter, M. J., Tjønneland, A., Grip, O., Amian, P., Barricarte, A., Bergmann, M. M., Boutron-Ruault, M. C., Cross, A., Hart, A. R., Kaaks, R., Key, T., Chirlaque López, M. D., ... DEFINe-IBD Investigators (2022). Obesity is Associated With Increased Risk of Crohn's disease, but not Ulcerative Colitis: A Pooled Analysis of Five Prospective Cohort Studies. Clinical Gastroenterology and Hepatology, 1048-1058. https://doi.org/10.1016/j.cgh.2021.06.049

Vancouver

Chan SSM, Chen Y, Casey K, Olen O, Ludvigsson JF, Carbonnel F o.a. Obesity is Associated With Increased Risk of Crohn's disease, but not Ulcerative Colitis: A Pooled Analysis of Five Prospective Cohort Studies. Clinical Gastroenterology and Hepatology. 2022;1048-1058. https://doi.org/10.1016/j.cgh.2021.06.049

Author

Chan, Simon S.M. ; Chen, Ye ; Casey, Kevin ; Olen, Ola ; Ludvigsson, Jonas F. ; Carbonnel, Franck ; Oldenburg, Bas ; Gunter, Marc J. ; Tjønneland, Anne ; Grip, Olof ; Amian, Pilar ; Barricarte, Aurelio ; Bergmann, Manuela M. ; Boutron-Ruault, Marie Christine ; Cross, Amanda ; Hart, Andrew R. ; Kaaks, Rudolf ; Key, Tim ; Chirlaque López, María Dolores ; Robert Luben, Luben ; Masala, Giovanna ; Manjer, Jonas ; Olsen, Anja ; Overvad, Kim ; Palli, Domenico ; Riboli, Elio ; Sánchez, Maria José ; Tumino, Rosario ; Vermeulen, Roel ; Verschuren, W. M.Monique ; Wareham, Nick ; Ananthakrishnan, Ashwin ; Burke, Kristin ; Lopes, Emily Walsh ; Richter, James ; Lochhead, Paul ; Chan, Andrew T. ; Wolk, Alicia ; Khalili, Hamed ; DEFINe-IBD Investigators. / Obesity is Associated With Increased Risk of Crohn's disease, but not Ulcerative Colitis : A Pooled Analysis of Five Prospective Cohort Studies. I: Clinical Gastroenterology and Hepatology. 2022 ; s. 1048-1058.

Bibtex

@article{45410f10c8f74bf8b55e82f44aa8425e,

title = "Obesity is Associated With Increased Risk of Crohn's disease, but not Ulcerative Colitis: A Pooled Analysis of Five Prospective Cohort Studies",

abstract = "Background and Aims: It is unclear whether obesity is associated with the development of inflammatory bowel disease despite compelling data from basic science studies. We therefore examined the association between obesity and risk of Crohn's disease (CD) and ulcerative colitis (UC). Methods: We conducted pooled analyses of 5 prospective cohorts with validated anthropometric measurements for body mass index (BMI) and waist-hip ratio and other lifestyle factors. Diagnoses of CD and UC were confirmed through medical records or ascertained using validated definitions. We used Cox proportional hazards modeling to calculate pooled multivariable-adjusted HRs (aHRs) and 95% confidence intervals (CIs). Results: Among 601,009 participants (age range, 18-98 years) with 10,110,018 person-years of follow-up, we confirmed 563 incident cases of CD and 1047 incident cases of UC. Obesity (baseline BMI ≥30 kg/m2) was associated with an increased risk of CD (pooled aHR, 1.34; 95% CI, 1.05-1.71, I2 = 0%) compared with normal BMI (18.5 to <25 kg/m2). Each 5 kg/m2 increment in baseline BMI was associated with a 16% increase in risk of CD (pooled aHR, 1.16; 95% CI, 1.05-1.22; I2 = 0%). Similarly, with each 5 kg/m2 increment in early adulthood BMI (age, 18-20 years), there was a 22% increase in risk of CD (pooled aHR, 1.22; 95% CI, 1.05-1.40; I2 = 13.6%). An increase in waist-hip ratio was associated with an increased risk of CD that did not reach statistical significance (pooled aHR across quartiles, 1.08; 95% CI, 0.97-1.19; I2 = 0%). No associations were observed between measures of obesity and risk of UC. Conclusions: In an adult population, obesity as measured by BMI was associated with an increased risk of older-onset CD but not UC.",

keywords = "Body Mass Index, Epidemiology, Inflammatory Bowel Diseases, Waist-Hip Ratio",

author = "Chan, {Simon S.M.} and Ye Chen and Kevin Casey and Ola Olen and Ludvigsson, {Jonas F.} and Franck Carbonnel and Bas Oldenburg and Gunter, {Marc J.} and Anne Tj{\o}nneland and Olof Grip and Pilar Amian and Aurelio Barricarte and Bergmann, {Manuela M.} and Boutron-Ruault, {Marie Christine} and Amanda Cross and Hart, {Andrew R.} and Rudolf Kaaks and Tim Key and {Chirlaque L{\'o}pez}, {Mar{\'i}a Dolores} and {Robert Luben}, Luben and Giovanna Masala and Jonas Manjer and Anja Olsen and Kim Overvad and Domenico Palli and Elio Riboli and S{\'a}nchez, {Maria Jos{\'e}} and Rosario Tumino and Roel Vermeulen and Verschuren, {W. M.Monique} and Nick Wareham and Ashwin Ananthakrishnan and Kristin Burke and Lopes, {Emily Walsh} and James Richter and Paul Lochhead and Chan, {Andrew T.} and Alicia Wolk and Hamed Khalili and {DEFINe-IBD Investigators}",

note = "Publisher Copyright: {\textcopyright} 2021 by the AGA Institute. Published by Elsevier, Inc.",

year = "2022",

doi = "10.1016/j.cgh.2021.06.049",

language = "English",

pages = "1048--1058",

journal = "Clinical Gastroenterology and Hepatology",

issn = "1542-3565",

publisher = "W.B.Saunders Co.",

}

RIS

TY - JOUR

T1 - Obesity is Associated With Increased Risk of Crohn's disease, but not Ulcerative Colitis

T2 - A Pooled Analysis of Five Prospective Cohort Studies

AU - Chan, Simon S.M.

AU - Chen, Ye

AU - Casey, Kevin

AU - Olen, Ola

AU - Ludvigsson, Jonas F.

AU - Carbonnel, Franck

AU - Oldenburg, Bas

AU - Gunter, Marc J.

AU - Tjønneland, Anne

AU - Grip, Olof

AU - Amian, Pilar

AU - Barricarte, Aurelio

AU - Bergmann, Manuela M.

AU - Boutron-Ruault, Marie Christine

AU - Cross, Amanda

AU - Hart, Andrew R.

AU - Kaaks, Rudolf

AU - Key, Tim

AU - Chirlaque López, María Dolores

AU - Robert Luben, Luben

AU - Masala, Giovanna

AU - Manjer, Jonas

AU - Olsen, Anja

AU - Overvad, Kim

AU - Palli, Domenico

AU - Riboli, Elio

AU - Sánchez, Maria José

AU - Tumino, Rosario

AU - Vermeulen, Roel

AU - Verschuren, W. M.Monique

AU - Wareham, Nick

AU - Ananthakrishnan, Ashwin

AU - Burke, Kristin

AU - Lopes, Emily Walsh

AU - Richter, James

AU - Lochhead, Paul

AU - Chan, Andrew T.

AU - Wolk, Alicia

AU - Khalili, Hamed

AU - DEFINe-IBD Investigators

PY - 2022

Y1 - 2022

N2 - Background and Aims: It is unclear whether obesity is associated with the development of inflammatory bowel disease despite compelling data from basic science studies. We therefore examined the association between obesity and risk of Crohn's disease (CD) and ulcerative colitis (UC). Methods: We conducted pooled analyses of 5 prospective cohorts with validated anthropometric measurements for body mass index (BMI) and waist-hip ratio and other lifestyle factors. Diagnoses of CD and UC were confirmed through medical records or ascertained using validated definitions. We used Cox proportional hazards modeling to calculate pooled multivariable-adjusted HRs (aHRs) and 95% confidence intervals (CIs). Results: Among 601,009 participants (age range, 18-98 years) with 10,110,018 person-years of follow-up, we confirmed 563 incident cases of CD and 1047 incident cases of UC. Obesity (baseline BMI ≥30 kg/m2) was associated with an increased risk of CD (pooled aHR, 1.34; 95% CI, 1.05-1.71, I2 = 0%) compared with normal BMI (18.5 to <25 kg/m2). Each 5 kg/m2 increment in baseline BMI was associated with a 16% increase in risk of CD (pooled aHR, 1.16; 95% CI, 1.05-1.22; I2 = 0%). Similarly, with each 5 kg/m2 increment in early adulthood BMI (age, 18-20 years), there was a 22% increase in risk of CD (pooled aHR, 1.22; 95% CI, 1.05-1.40; I2 = 13.6%). An increase in waist-hip ratio was associated with an increased risk of CD that did not reach statistical significance (pooled aHR across quartiles, 1.08; 95% CI, 0.97-1.19; I2 = 0%). No associations were observed between measures of obesity and risk of UC. Conclusions: In an adult population, obesity as measured by BMI was associated with an increased risk of older-onset CD but not UC.

AB - Background and Aims: It is unclear whether obesity is associated with the development of inflammatory bowel disease despite compelling data from basic science studies. We therefore examined the association between obesity and risk of Crohn's disease (CD) and ulcerative colitis (UC). Methods: We conducted pooled analyses of 5 prospective cohorts with validated anthropometric measurements for body mass index (BMI) and waist-hip ratio and other lifestyle factors. Diagnoses of CD and UC were confirmed through medical records or ascertained using validated definitions. We used Cox proportional hazards modeling to calculate pooled multivariable-adjusted HRs (aHRs) and 95% confidence intervals (CIs). Results: Among 601,009 participants (age range, 18-98 years) with 10,110,018 person-years of follow-up, we confirmed 563 incident cases of CD and 1047 incident cases of UC. Obesity (baseline BMI ≥30 kg/m2) was associated with an increased risk of CD (pooled aHR, 1.34; 95% CI, 1.05-1.71, I2 = 0%) compared with normal BMI (18.5 to <25 kg/m2). Each 5 kg/m2 increment in baseline BMI was associated with a 16% increase in risk of CD (pooled aHR, 1.16; 95% CI, 1.05-1.22; I2 = 0%). Similarly, with each 5 kg/m2 increment in early adulthood BMI (age, 18-20 years), there was a 22% increase in risk of CD (pooled aHR, 1.22; 95% CI, 1.05-1.40; I2 = 13.6%). An increase in waist-hip ratio was associated with an increased risk of CD that did not reach statistical significance (pooled aHR across quartiles, 1.08; 95% CI, 0.97-1.19; I2 = 0%). No associations were observed between measures of obesity and risk of UC. Conclusions: In an adult population, obesity as measured by BMI was associated with an increased risk of older-onset CD but not UC.

KW - Body Mass Index

KW - Epidemiology

KW - Inflammatory Bowel Diseases

KW - Waist-Hip Ratio

U2 - 10.1016/j.cgh.2021.06.049

DO - 10.1016/j.cgh.2021.06.049

M3 - Journal article

C2 - 34242756

AN - SCOPUS:85113386738

SP - 1048

EP - 1058

JO - Clinical Gastroenterology and Hepatology

JF - Clinical Gastroenterology and Hepatology

SN - 1542-3565

ER -

ID: 286490659