Obesity and asthma: current knowledge and future needs
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Obesity and asthma : current knowledge and future needs. / Sivapalan, Pradeesh; Diamant, Zuzana; Ulrik, Charlotte Suppli.
I: Current Opinion in Pulmonary Medicine, Bind 21, Nr. 1, 01.2015, s. 80-85.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Obesity and asthma
T2 - current knowledge and future needs
AU - Sivapalan, Pradeesh
AU - Diamant, Zuzana
AU - Ulrik, Charlotte Suppli
PY - 2015/1
Y1 - 2015/1
N2 - PURPOSE OF REVIEW: Obesity has significant impact on asthma incidence and manifestations. The purpose of the review is to discuss recent observations regarding the association between obesity and asthma focusing on underlying mechanisms, clinical presentation, response to therapy and effect of weight reduction.RECENT FINDINGS: Clinical and epidemiological studies indicate that obese patients with asthma may represent a unique phenotype, which is more difficult to control, less responsive to asthma medications and by that may have higher healthcare utilization. A number of common comorbidities have been linked to both obesity and asthma, and may, therefore, contribute to the obese-asthma phenotype. Furthermore, recently published studies indicate that even a modest weight reduction can improve clinical manifestations and outcome of asthma.SUMMARY: Compared with normal-weight patients, obese and overweight patients with asthma have poorer asthma control and respond less to corticosteroid therapy. Future studies focusing on the mechanism underlying both obesity and asthma including the obese-asthma phenotype are required to better characterize the link between the conditions and target the management of this patient group.
AB - PURPOSE OF REVIEW: Obesity has significant impact on asthma incidence and manifestations. The purpose of the review is to discuss recent observations regarding the association between obesity and asthma focusing on underlying mechanisms, clinical presentation, response to therapy and effect of weight reduction.RECENT FINDINGS: Clinical and epidemiological studies indicate that obese patients with asthma may represent a unique phenotype, which is more difficult to control, less responsive to asthma medications and by that may have higher healthcare utilization. A number of common comorbidities have been linked to both obesity and asthma, and may, therefore, contribute to the obese-asthma phenotype. Furthermore, recently published studies indicate that even a modest weight reduction can improve clinical manifestations and outcome of asthma.SUMMARY: Compared with normal-weight patients, obese and overweight patients with asthma have poorer asthma control and respond less to corticosteroid therapy. Future studies focusing on the mechanism underlying both obesity and asthma including the obese-asthma phenotype are required to better characterize the link between the conditions and target the management of this patient group.
KW - Anti-Asthmatic Agents
KW - Asthma
KW - Comorbidity
KW - Humans
KW - Inflammation
KW - Obesity
KW - Phenotype
KW - Prevalence
KW - Quality of Life
KW - Severity of Illness Index
KW - Weight Loss
U2 - 10.1097/MCP.0000000000000119
DO - 10.1097/MCP.0000000000000119
M3 - Review
C2 - 25405670
VL - 21
SP - 80
EP - 85
JO - Current Opinion in Pulmonary Medicine
JF - Current Opinion in Pulmonary Medicine
SN - 1070-5287
IS - 1
ER -
ID: 156034068