TY - JOUR

T1 - Nye hormoner relateret til calcium- og fosfathomøostasen ved nyresygdom

AU - Mace, Maria Lerche

AU - Ølgaard, Klaus

AU - Lewin, Eva

PY - 2018

Y1 - 2018

N2 - Calcium and phosphate levels are regulated by a complex interplay between parathyroid hormone (PTH), calcitriol, fibroblast growth factor 23 (FGF23) and its co-receptor αKlotho. Kidney failure causes severe disturbances in the mineral and bone homeostasis resulting in phosphate retention, hypocalcaemia and high plasma levels of FGF23 and PTH, and the patients develop fragile bones and vascular calcifications. Today's treatments aim to lower the levels of phosphate and PTH. Future studies need to clarify, if lowering the FGF23 level or supplementation with αKlotho will improve survival for patients with chronic kidney disease.

AB - Calcium and phosphate levels are regulated by a complex interplay between parathyroid hormone (PTH), calcitriol, fibroblast growth factor 23 (FGF23) and its co-receptor αKlotho. Kidney failure causes severe disturbances in the mineral and bone homeostasis resulting in phosphate retention, hypocalcaemia and high plasma levels of FGF23 and PTH, and the patients develop fragile bones and vascular calcifications. Today's treatments aim to lower the levels of phosphate and PTH. Future studies need to clarify, if lowering the FGF23 level or supplementation with αKlotho will improve survival for patients with chronic kidney disease.

KW - Calcium/metabolism

KW - Cardiovascular Diseases/metabolism

KW - Fibroblast Growth Factors/metabolism

KW - Glucuronidase/metabolism

KW - Homeostasis

KW - Humans

KW - Parathyroid Hormone/metabolism

KW - Phosphates/metabolism

KW - Renal Insufficiency/metabolism

KW - Vitamin D/metabolism

M3 - Tidsskriftartikel

C2 - 29804564

VL - 180

JO - Ugeskrift for Laeger

JF - Ugeskrift for Laeger

SN - 0041-5782

IS - 21

M1 - V05170353

ER -