Nursing Home Admission and Initiation of Domiciliary Care After Ischemic Stroke – The Importance of Time to Thrombolysis

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Standard

Nursing Home Admission and Initiation of Domiciliary Care After Ischemic Stroke – The Importance of Time to Thrombolysis. / Butt, Jawad H.; Kruuse, Christina; Kragholm, Kristian; Johnsen, Søren Paaske; Kristensen, Søren Lund; Havers-Borgersen, Eva; Yafasova, Adelina; Østergaard, Lauge; Gislason, Gunnar H.; Torp-Pedersen, Christian; Køber, Lars; Fosbøl, Emil L.

I: Journal of Stroke and Cerebrovascular Diseases, Bind 30, Nr. 8, 105916, 08.2021.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Butt, JH, Kruuse, C, Kragholm, K, Johnsen, SP, Kristensen, SL, Havers-Borgersen, E, Yafasova, A, Østergaard, L, Gislason, GH, Torp-Pedersen, C, Køber, L & Fosbøl, EL 2021, 'Nursing Home Admission and Initiation of Domiciliary Care After Ischemic Stroke – The Importance of Time to Thrombolysis', Journal of Stroke and Cerebrovascular Diseases, bind 30, nr. 8, 105916. https://doi.org/10.1016/j.jstrokecerebrovasdis.2021.105916

APA

Butt, J. H., Kruuse, C., Kragholm, K., Johnsen, S. P., Kristensen, S. L., Havers-Borgersen, E., Yafasova, A., Østergaard, L., Gislason, G. H., Torp-Pedersen, C., Køber, L., & Fosbøl, E. L. (2021). Nursing Home Admission and Initiation of Domiciliary Care After Ischemic Stroke – The Importance of Time to Thrombolysis. Journal of Stroke and Cerebrovascular Diseases, 30(8), [105916]. https://doi.org/10.1016/j.jstrokecerebrovasdis.2021.105916

Vancouver

Butt JH, Kruuse C, Kragholm K, Johnsen SP, Kristensen SL, Havers-Borgersen E o.a. Nursing Home Admission and Initiation of Domiciliary Care After Ischemic Stroke – The Importance of Time to Thrombolysis. Journal of Stroke and Cerebrovascular Diseases. 2021 aug.;30(8). 105916. https://doi.org/10.1016/j.jstrokecerebrovasdis.2021.105916

Author

Butt, Jawad H. ; Kruuse, Christina ; Kragholm, Kristian ; Johnsen, Søren Paaske ; Kristensen, Søren Lund ; Havers-Borgersen, Eva ; Yafasova, Adelina ; Østergaard, Lauge ; Gislason, Gunnar H. ; Torp-Pedersen, Christian ; Køber, Lars ; Fosbøl, Emil L. / Nursing Home Admission and Initiation of Domiciliary Care After Ischemic Stroke – The Importance of Time to Thrombolysis. I: Journal of Stroke and Cerebrovascular Diseases. 2021 ; Bind 30, Nr. 8.

Bibtex

@article{299616d373964ff89cb174038b9019bb,

title = "Nursing Home Admission and Initiation of Domiciliary Care After Ischemic Stroke – The Importance of Time to Thrombolysis",

abstract = "Objectives: There is a paucity of data on the risk of nursing home admission or domiciliary care initiation according to time to intravenous thrombolysis for ischemic stroke. We investigated the association between time to intravenous thrombolysis and the composite of nursing home admission or domiciliary care initiation in patients with acute ischemic stroke. Materials and Methods: In this nationwide cohort study, all stroke patients treated with intravenous thrombolysis (2011–2015) and alive at discharge were identified from the Danish Stroke Registry and other nationwide registries. The composite of nursing home admission or domiciliary care initiation one year post-discharge according to time to thrombolysis was examined with multivariable Cox regression. Results: The study population comprised 4,349 patients (median age 67 years [25th-75th percentile 57–75], 65.2% men). The median National Institutes of Health Stroke Scale score at presentation was 5, and the median time from symptom-onset to initiation of thrombolysis was 143 min. The absolute 1-year risk of the composite endpoint was 14.0% (95%CI, 11.5–16.8%) in the ≤90 min group, 16.6% (15.1–18.1%) in the 91–180min group, and 16.0% (14.0–18.2%) in the 181–270 min group. Compared with thrombolysis ≤90 min, time to thrombolysis between 91–180 min and 181–270 min was associated with a significantly higher risk of the composite endpoint (hazard ratio 1.31 [1.04–1.65] and 1.47 [1.14–1.91], respectively). Conclusions: In patients admitted with ischemic stroke, increasing time to thrombolysis was associated with a greater risk of the composite of nursing home admission or domiciliary care initiation. Continued efforts to shorten the time delay from symptom-onset to initiation of thrombolysis are warranted.",

keywords = "Epidemiology, Nursing home, Stroke, Thrombolytic therapy",

author = "Butt, {Jawad H.} and Christina Kruuse and Kristian Kragholm and Johnsen, {S{\o}ren Paaske} and Kristensen, {S{\o}ren Lund} and Eva Havers-Borgersen and Adelina Yafasova and Lauge {\O}stergaard and Gislason, {Gunnar H.} and Christian Torp-Pedersen and Lars K{\o}ber and Fosb{\o}l, {Emil L.}",

note = "Publisher Copyright: {\textcopyright} 2021 Elsevier Inc.",

year = "2021",

month = aug,

doi = "10.1016/j.jstrokecerebrovasdis.2021.105916",

language = "English",

volume = "30",

journal = "Journal of Stroke & Cerebrovascular Diseases",

issn = "1052-3057",

publisher = "W.B.Saunders Co.",

number = "8",

}

RIS

TY - JOUR

T1 - Nursing Home Admission and Initiation of Domiciliary Care After Ischemic Stroke – The Importance of Time to Thrombolysis

AU - Butt, Jawad H.

AU - Kruuse, Christina

AU - Kragholm, Kristian

AU - Johnsen, Søren Paaske

AU - Kristensen, Søren Lund

AU - Havers-Borgersen, Eva

AU - Yafasova, Adelina

AU - Østergaard, Lauge

AU - Gislason, Gunnar H.

AU - Torp-Pedersen, Christian

AU - Køber, Lars

AU - Fosbøl, Emil L.

PY - 2021/8

Y1 - 2021/8

N2 - Objectives: There is a paucity of data on the risk of nursing home admission or domiciliary care initiation according to time to intravenous thrombolysis for ischemic stroke. We investigated the association between time to intravenous thrombolysis and the composite of nursing home admission or domiciliary care initiation in patients with acute ischemic stroke. Materials and Methods: In this nationwide cohort study, all stroke patients treated with intravenous thrombolysis (2011–2015) and alive at discharge were identified from the Danish Stroke Registry and other nationwide registries. The composite of nursing home admission or domiciliary care initiation one year post-discharge according to time to thrombolysis was examined with multivariable Cox regression. Results: The study population comprised 4,349 patients (median age 67 years [25th-75th percentile 57–75], 65.2% men). The median National Institutes of Health Stroke Scale score at presentation was 5, and the median time from symptom-onset to initiation of thrombolysis was 143 min. The absolute 1-year risk of the composite endpoint was 14.0% (95%CI, 11.5–16.8%) in the ≤90 min group, 16.6% (15.1–18.1%) in the 91–180min group, and 16.0% (14.0–18.2%) in the 181–270 min group. Compared with thrombolysis ≤90 min, time to thrombolysis between 91–180 min and 181–270 min was associated with a significantly higher risk of the composite endpoint (hazard ratio 1.31 [1.04–1.65] and 1.47 [1.14–1.91], respectively). Conclusions: In patients admitted with ischemic stroke, increasing time to thrombolysis was associated with a greater risk of the composite of nursing home admission or domiciliary care initiation. Continued efforts to shorten the time delay from symptom-onset to initiation of thrombolysis are warranted.

AB - Objectives: There is a paucity of data on the risk of nursing home admission or domiciliary care initiation according to time to intravenous thrombolysis for ischemic stroke. We investigated the association between time to intravenous thrombolysis and the composite of nursing home admission or domiciliary care initiation in patients with acute ischemic stroke. Materials and Methods: In this nationwide cohort study, all stroke patients treated with intravenous thrombolysis (2011–2015) and alive at discharge were identified from the Danish Stroke Registry and other nationwide registries. The composite of nursing home admission or domiciliary care initiation one year post-discharge according to time to thrombolysis was examined with multivariable Cox regression. Results: The study population comprised 4,349 patients (median age 67 years [25th-75th percentile 57–75], 65.2% men). The median National Institutes of Health Stroke Scale score at presentation was 5, and the median time from symptom-onset to initiation of thrombolysis was 143 min. The absolute 1-year risk of the composite endpoint was 14.0% (95%CI, 11.5–16.8%) in the ≤90 min group, 16.6% (15.1–18.1%) in the 91–180min group, and 16.0% (14.0–18.2%) in the 181–270 min group. Compared with thrombolysis ≤90 min, time to thrombolysis between 91–180 min and 181–270 min was associated with a significantly higher risk of the composite endpoint (hazard ratio 1.31 [1.04–1.65] and 1.47 [1.14–1.91], respectively). Conclusions: In patients admitted with ischemic stroke, increasing time to thrombolysis was associated with a greater risk of the composite of nursing home admission or domiciliary care initiation. Continued efforts to shorten the time delay from symptom-onset to initiation of thrombolysis are warranted.

KW - Epidemiology

KW - Nursing home

KW - Stroke

KW - Thrombolytic therapy

U2 - 10.1016/j.jstrokecerebrovasdis.2021.105916

DO - 10.1016/j.jstrokecerebrovasdis.2021.105916

M3 - Journal article

C2 - 34144336

AN - SCOPUS:85107905071

VL - 30

JO - Journal of Stroke & Cerebrovascular Diseases

JF - Journal of Stroke & Cerebrovascular Diseases

SN - 1052-3057

IS - 8

M1 - 105916

ER -

ID: 285805436