Novel Roles for the Transcriptional Repressor E4BP4 in Both Cardiac Physiology and Pathophysiology
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
Novel Roles for the Transcriptional Repressor E4BP4 in Both Cardiac Physiology and Pathophysiology. / Mia, Sobuj; Sonkar, Ravi; Williams, Lamario; Latimer, Mary N.; Rawnsley, David R.; Rana, Samir; He, Jin; Dierickx, Pieterjan; Kim, Teayoun; Xie, Min; Habegger, Kirk M.; Kubo, Masato; Zhou, Lufang; Thomsen, Morten B.; Prabhu, Sumanth D.; Frank, Stuart J.; Brookes, Paul S.; Lazar, Mitchell A.; Diwan, Abhinav; Young, Martin E.
I: JACC: Basic to Translational Science, Bind 8, Nr. 9, 2023, s. 1141-1156.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Novel Roles for the Transcriptional Repressor E4BP4 in Both Cardiac Physiology and Pathophysiology
AU - Mia, Sobuj
AU - Sonkar, Ravi
AU - Williams, Lamario
AU - Latimer, Mary N.
AU - Rawnsley, David R.
AU - Rana, Samir
AU - He, Jin
AU - Dierickx, Pieterjan
AU - Kim, Teayoun
AU - Xie, Min
AU - Habegger, Kirk M.
AU - Kubo, Masato
AU - Zhou, Lufang
AU - Thomsen, Morten B.
AU - Prabhu, Sumanth D.
AU - Frank, Stuart J.
AU - Brookes, Paul S.
AU - Lazar, Mitchell A.
AU - Diwan, Abhinav
AU - Young, Martin E.
N1 - Publisher Copyright: © 2023 The Authors
PY - 2023
Y1 - 2023
N2 - Circadian clocks temporally orchestrate biological processes critical for cellular/organ function. For example, the cardiomyocyte circadian clock modulates cardiac metabolism, signaling, and electrophysiology over the course of the day, such that, disruption of the clock leads to age-onset cardiomyopathy (through unknown mechanisms). Here, we report that genetic disruption of the cardiomyocyte clock results in chronic induction of the transcriptional repressor E4BP4. Importantly, E4BP4 deletion prevents age-onset cardiomyopathy following clock disruption. These studies also indicate that E4BP4 regulates both cardiac metabolism (eg, fatty acid oxidation) and electrophysiology (eg, QT interval). Collectively, these studies reveal that E4BP4 is a novel regulator of both cardiac physiology and pathophysiology.
AB - Circadian clocks temporally orchestrate biological processes critical for cellular/organ function. For example, the cardiomyocyte circadian clock modulates cardiac metabolism, signaling, and electrophysiology over the course of the day, such that, disruption of the clock leads to age-onset cardiomyopathy (through unknown mechanisms). Here, we report that genetic disruption of the cardiomyocyte clock results in chronic induction of the transcriptional repressor E4BP4. Importantly, E4BP4 deletion prevents age-onset cardiomyopathy following clock disruption. These studies also indicate that E4BP4 regulates both cardiac metabolism (eg, fatty acid oxidation) and electrophysiology (eg, QT interval). Collectively, these studies reveal that E4BP4 is a novel regulator of both cardiac physiology and pathophysiology.
KW - chronobiology
KW - electrophysiology
KW - heart failure
KW - metabolism
UR - http://www.scopus.com/inward/record.url?scp=85170535344&partnerID=8YFLogxK
U2 - 10.1016/j.jacbts.2023.03.016
DO - 10.1016/j.jacbts.2023.03.016
M3 - Journal article
C2 - 37791313
AN - SCOPUS:85170535344
VL - 8
SP - 1141
EP - 1156
JO - JACC: Basic to Translational Science
JF - JACC: Basic to Translational Science
SN - 2452-302X
IS - 9
ER -
ID: 369136941