Novel methodology to enrich medium- and short-chain fatty acids in milk fat to improve metabolic health
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Novel methodology to enrich medium- and short-chain fatty acids in milk fat to improve metabolic health. / Samsø Mathiasen, Sally; Kanta, Josephine M.; Frydenberg, Rikke P.; Lundsgaard, Annemarie; Guo, Zheng; Fritzen, Andreas M.; Kiens, Bente; Wiking, Lars; Kleinert, Maximilian.
I: Food and Function, Bind 15, 2024, s. 7951-7960.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Novel methodology to enrich medium- and short-chain fatty acids in milk fat to improve metabolic health
AU - Samsø Mathiasen, Sally
AU - Kanta, Josephine M.
AU - Frydenberg, Rikke P.
AU - Lundsgaard, Annemarie
AU - Guo, Zheng
AU - Fritzen, Andreas M.
AU - Kiens, Bente
AU - Wiking, Lars
AU - Kleinert, Maximilian
N1 - Publisher Copyright: © 2024 The Royal Society of Chemistry.
PY - 2024
Y1 - 2024
N2 - Dietary short- and medium-chain fatty acids have been shown to elevate circulating ketone bodies and confer metabolic health benefits. Cow milk fat contains these lipids in a balanced mix but in relatively low concentrations. Enriching them could amplify health benefits of dairy products. Here, we used a volatility-based workflow to produce milk fat with a 2-fold enrichment of medium- and short-chain fatty acids (referred to as MSFAT). Our proof-of-concept studies in mice demonstrated that intake of MSFAT increased circulating ketone bodies, reduced blood glucose levels, and suppressed food intake. In humans, ingestion of MSFAT resulted in increased circulating ketone bodies, trended to attenuate (p = 0.07) postprandial glucose excursion, and acutely elevated energy expenditure. Our findings show that milk products enriched with MSFAT may hold significant metabolic advantages.
AB - Dietary short- and medium-chain fatty acids have been shown to elevate circulating ketone bodies and confer metabolic health benefits. Cow milk fat contains these lipids in a balanced mix but in relatively low concentrations. Enriching them could amplify health benefits of dairy products. Here, we used a volatility-based workflow to produce milk fat with a 2-fold enrichment of medium- and short-chain fatty acids (referred to as MSFAT). Our proof-of-concept studies in mice demonstrated that intake of MSFAT increased circulating ketone bodies, reduced blood glucose levels, and suppressed food intake. In humans, ingestion of MSFAT resulted in increased circulating ketone bodies, trended to attenuate (p = 0.07) postprandial glucose excursion, and acutely elevated energy expenditure. Our findings show that milk products enriched with MSFAT may hold significant metabolic advantages.
U2 - 10.1039/d4fo00267a
DO - 10.1039/d4fo00267a
M3 - Journal article
C2 - 38980698
AN - SCOPUS:85198074649
VL - 15
SP - 7951
EP - 7960
JO - Food & Function
JF - Food & Function
SN - 2042-6496
ER -
ID: 399114358