Novel Insights in the Management of Vernal Keratoconjunctivitis (VKC): European Expert Consensus Using a Modified Nominal Group Technique

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  • Annegret Dahlmann-Noor
  • Stefano Bonini
  • Dominique Bremond-Gignac
  • Heegaard, Steffen
  • Andrea Leonardi
  • Jesús Montero
  • Eduardo D. Silva
  • The EUR-VKC Group
Introduction
Vernal keratoconjunctivitis (VKC) is a rare, severe allergic ocular disease, typically occurring in children and adolescents, that can have a significant impact on quality of life and lead to visual impairment. Long-term treatment may be necessary to tackle chronic inflammation and topical corticosteroid dependency must be minimised due to the risk of complications. There is a need for unified clinical guidance to aid the assessment, diagnosis and management of VKC across Europe. The aim of this expert panel (the EUR-VKC Group) was to provide clear guidance for primary care physicians and general ophthalmologists involved in the diagnosis and management of VKC.

Methods
An expert group of seven European ophthalmologists was convened and a modified nominal group technique used to develop key recommendations on VKC management. The recommendations were subject to up to two rounds of voting using a 5-point Likert scale to ascertain consensus and the strength of each recommendation. Consensus was set at a predetermined threshold of ≥ 75.0% of experts selecting ‘Strongly agree’ or ‘Agree’.

Results
A total of 47 recommendations were developed relating to the assessment of key of VKC, guidance on who and when to refer, as well as treatment-escalation pathways, long-term follow-up, and supportive care and education. All recommendations reached consensus after two rounds. The group emphasise how timely diagnosis and treatment initiation that is appropriate to disease severity are crucial to benefit patients with VKC. Patients with signs (‘red flags’) indicating severe VKC, or persistent mild-to-moderate VKC that is non-responsive following 2–4 weeks of treatment, should be referred to a sub-specialist.

Conclusion
The EUR-VKC Group provides recommendations on the assessment, diagnosis, management, referral and follow-up of patients with VKC. It also provides a framework to facilitate collaboration between primary care physicians, general ophthalmologists and sub-specialists to improve the outcomes for patients with VKC.
OriginalsprogEngelsk
TidsskriftOphthalmology and Therapy
Vol/bind12
Sider (fra-til)pages1207–1222
Antal sider16
ISSN2193-8245
DOI
StatusUdgivet - 2023

Bibliografisk note

Funding Information:
Publication support for third-party writing assistance for this article, provided by Synergy Vision, UK, and all associated publication costs (including the journal’s Rapid Service fee) were funded by Santen SA.

Publisher Copyright:
© 2023, The Author(s).

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