TY - JOUR

T1 - Novel insight into the distribution of L-cells in the rat intestinal tract

AU - Hansen, Carl Frederik

AU - Vrang, Niels

AU - Sangild, Per Torp

AU - Jelsing, Jacob

N1 - CURIS 2013 NEXS 179

PY - 2013

Y1 - 2013

N2 - Gut secreted incretin hormones and gastric bypass surgery currently provides some of the most successful treatments for diabetes and obesity respectively. However, despite the evident importance of the gut endocrine system no information exists on the total number and distribution of different types of endocrine cells in the gut. Here we have used the established preclinical Zucker Diabetic Fatty (ZDF) rat model which displays elevated levels of GLP-1 to assess L-cell distribution and L-cell dynamics in the full rostro-caudal extension of the rat intestinal tract.

AB - Gut secreted incretin hormones and gastric bypass surgery currently provides some of the most successful treatments for diabetes and obesity respectively. However, despite the evident importance of the gut endocrine system no information exists on the total number and distribution of different types of endocrine cells in the gut. Here we have used the established preclinical Zucker Diabetic Fatty (ZDF) rat model which displays elevated levels of GLP-1 to assess L-cell distribution and L-cell dynamics in the full rostro-caudal extension of the rat intestinal tract.

M3 - Journal article

C2 - 23634245

VL - 5

SP - 347

EP - 358

JO - American Journal of Translational Research

JF - American Journal of Translational Research

SN - 1943-8141

IS - 3

ER -