TY - JOUR

T1 - Normal values of left ventricularmass and cardiac chamber volumes assessed by 320-detector computed tomography angiography in the Copenhagen General Population Study

AU - Fuchs, Andreas

AU - Mejdahl, Mads Rams

AU - Kühl, J Tobias

AU - Stisen, Zara R.

AU - Nilsson, Emma Julia P

AU - Køber, Lars V.

AU - Nordestgaard, Børge G.

AU - Kofoed, Klaus F.

PY - 2016

Y1 - 2016

N2 - Aims Normal values of left ventricular mass (LVM) and cardiac chamber sizes are prerequisites for the diagnosis of individuals with heart disease. LVM and cardiac chamber sizes may be recorded during cardiac computed tomography angiography (CCTA), and thus modality specific normal values are needed. Methods and results We studied 569 healthy subjects undergoing 320-detector CCTA as a part of the Copenhagen General Population Study. LVM as well as ventricular and atrial volumes was assessed with semi-automated software stratified by gender and age decades and indexed by body surface area (BSA). Mean age was 55 (range: 40-84) years, and 188 (33%) were men. BSA-indexed 97.5th percentile cut-off values: LVM 80 and 65 gr/m2, left ventricular volume 97 and 83 mL/m2, right ventricular volume 120 and 102 mL/m2, left atrial volume 60 and 57 mL/m2, and right atrial volume 85 and 73 mL/m2 for men and women, respectively. Men had greater absolute and indexed LVM and chamber volumes than women. For both genders, indexed ventricular volumes declined, whereas indexed atrial volumes increased in advancing age groups. For men, indexed LVM declined in advancing age groups. In multivariate analyses, gender, BSA, systolic blood pressure, and hard physical activity accounted for 63% of variance in LVM. Conclusion In this cross-sectional general population study, men have greater indexed LVM and chamber volumes than women, and cardiac indexed volumes vary between age groups in both genders. These findings demonstrate the need for age-and gender-specific normal values for clinical diagnostic purposes.

AB - Aims Normal values of left ventricular mass (LVM) and cardiac chamber sizes are prerequisites for the diagnosis of individuals with heart disease. LVM and cardiac chamber sizes may be recorded during cardiac computed tomography angiography (CCTA), and thus modality specific normal values are needed. Methods and results We studied 569 healthy subjects undergoing 320-detector CCTA as a part of the Copenhagen General Population Study. LVM as well as ventricular and atrial volumes was assessed with semi-automated software stratified by gender and age decades and indexed by body surface area (BSA). Mean age was 55 (range: 40-84) years, and 188 (33%) were men. BSA-indexed 97.5th percentile cut-off values: LVM 80 and 65 gr/m2, left ventricular volume 97 and 83 mL/m2, right ventricular volume 120 and 102 mL/m2, left atrial volume 60 and 57 mL/m2, and right atrial volume 85 and 73 mL/m2 for men and women, respectively. Men had greater absolute and indexed LVM and chamber volumes than women. For both genders, indexed ventricular volumes declined, whereas indexed atrial volumes increased in advancing age groups. For men, indexed LVM declined in advancing age groups. In multivariate analyses, gender, BSA, systolic blood pressure, and hard physical activity accounted for 63% of variance in LVM. Conclusion In this cross-sectional general population study, men have greater indexed LVM and chamber volumes than women, and cardiac indexed volumes vary between age groups in both genders. These findings demonstrate the need for age-and gender-specific normal values for clinical diagnostic purposes.

KW - Atrial

KW - Cardiovascular computed tomography

KW - Myocardium

KW - Population

KW - Ventricular

KW - Volumes

U2 - 10.1093/ehjci/jev337

DO - 10.1093/ehjci/jev337

M3 - Journal article

C2 - 26758412

AN - SCOPUS:84992151453

VL - 17

SP - 1009

EP - 1017

JO - European Heart Journal Cardiovascular Imaging

JF - European Heart Journal Cardiovascular Imaging

SN - 2047-2404

IS - 9

ER -