No proarrhythmic properties of the antibiotics Moxifloxacin or Azithromycin in anaesthetized dogs with chronic-AV block
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No proarrhythmic properties of the antibiotics Moxifloxacin or Azithromycin in anaesthetized dogs with chronic-AV block. / Thomsen, Morten Bækgaard; Beekman, J D M; Attevelt, N J M; Takahara, A; Sugiyama, A; Chiba, K; Vos, M A.
I: British Journal of Pharmacology, Bind 149, Nr. 8, 12.2006, s. 1039-48.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - No proarrhythmic properties of the antibiotics Moxifloxacin or Azithromycin in anaesthetized dogs with chronic-AV block
AU - Thomsen, Morten Bækgaard
AU - Beekman, J D M
AU - Attevelt, N J M
AU - Takahara, A
AU - Sugiyama, A
AU - Chiba, K
AU - Vos, M A
PY - 2006/12
Y1 - 2006/12
N2 - The therapeutically available quinolone antibiotic moxifloxacin has been used as a positive control for prolonging the QT interval in both clinical and non-clinical studies designed to assess the potential of new drugs to delay cardiac repolarization. Despite moxifloxacin prolonging QT, it has not been shown to cause torsades de pointes arrhythmias (TdP). Azithromycin is a macrolide antibiotic that has rarely been associated, clinically, with cases of proarrhythmia. As there is a lack of clinical data available, the cardiac safety of these drugs was assessed in a TdP-susceptible animal model by evaluating their repolarization and proarrhythmia effects.
AB - The therapeutically available quinolone antibiotic moxifloxacin has been used as a positive control for prolonging the QT interval in both clinical and non-clinical studies designed to assess the potential of new drugs to delay cardiac repolarization. Despite moxifloxacin prolonging QT, it has not been shown to cause torsades de pointes arrhythmias (TdP). Azithromycin is a macrolide antibiotic that has rarely been associated, clinically, with cases of proarrhythmia. As there is a lack of clinical data available, the cardiac safety of these drugs was assessed in a TdP-susceptible animal model by evaluating their repolarization and proarrhythmia effects.
KW - Anesthesia
KW - Animals
KW - Anti-Arrhythmia Agents
KW - Anti-Bacterial Agents
KW - Arrhythmias, Cardiac
KW - Aza Compounds
KW - Azithromycin
KW - Dogs
KW - Dose-Response Relationship, Drug
KW - Electric Stimulation
KW - Electroencephalography
KW - Electrophysiology
KW - Heart Block
KW - Heart Rate
KW - Long QT Syndrome
KW - Phenethylamines
KW - Quinolines
KW - Sulfonamides
KW - Torsades de Pointes
U2 - 10.1038/sj.bjp.0706900
DO - 10.1038/sj.bjp.0706900
M3 - Journal article
C2 - 17088870
VL - 149
SP - 1039
EP - 1048
JO - British Journal of Pharmacology
JF - British Journal of Pharmacology
SN - 0007-1188
IS - 8
ER -
ID: 45965543