No association between DGKH and bipolar disorder in a Scandinavian case-control sample
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No association between DGKH and bipolar disorder in a Scandinavian case-control sample. / Tesli, Martin; Kähler, Anna; Andreassen, Bettina; Werge, Thomas; Mors, Ole; Mellerup, Erling; Koefoed, Pernille; Melle, Ingrid; Morken, Gunnar; Wirgenes, Katrine; Andreassen, Ole; Djurovic, Srdjan; Tesli, Martin; Kähler, Anna K; Andreassen, Bettina Kulle; Werge, Thomas; Mors, Ole; Mellerup, Erling; Koefoed, Pernille; Melle, Ingrid; Morken, Gunnar; Wirgenes, Katrine V; Andreassen, Ole A; Djurovic, Srdjan.
I: Psychiatric Genetics, Bind 19, Nr. 5, 2009, s. 269-72.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - No association between DGKH and bipolar disorder in a Scandinavian case-control sample
AU - Tesli, Martin
AU - Kähler, Anna
AU - Andreassen, Bettina
AU - Werge, Thomas
AU - Mors, Ole
AU - Mellerup, Erling
AU - Koefoed, Pernille
AU - Melle, Ingrid
AU - Morken, Gunnar
AU - Wirgenes, Katrine
AU - Andreassen, Ole
AU - Djurovic, Srdjan
AU - Tesli, Martin
AU - Kähler, Anna K
AU - Andreassen, Bettina Kulle
AU - Werge, Thomas
AU - Mors, Ole
AU - Mellerup, Erling
AU - Koefoed, Pernille
AU - Melle, Ingrid
AU - Morken, Gunnar
AU - Wirgenes, Katrine V
AU - Andreassen, Ole A
AU - Djurovic, Srdjan
N1 - Keywords: Adult; Bipolar Disorder; Case-Control Studies; Diacylglycerol Kinase; European Continental Ancestry Group; Female; Genetic Markers; Genetic Predisposition to Disease; Humans; Male; Middle Aged; Scandinavia
PY - 2009
Y1 - 2009
N2 - Single nucleotide polymorphisms (SNPs) in diacylglycerol kinase eta (DGKH) have recently been shown to be associated with bipolar disorder (BD). To replicate this finding, we carried out a gene-wide genotyping of 36 tagSNPs in DGKH and performed a population-based association study on two Scandinavian samples, with successful genotyping of 594 BD cases and 1421 healthy controls. We found no significant association after multiple-testing correction between any of these SNPs and BD in our sample. Thus, it is unlikely that these genetic variations confer susceptibility to BD in this large Scandinavian sample.
AB - Single nucleotide polymorphisms (SNPs) in diacylglycerol kinase eta (DGKH) have recently been shown to be associated with bipolar disorder (BD). To replicate this finding, we carried out a gene-wide genotyping of 36 tagSNPs in DGKH and performed a population-based association study on two Scandinavian samples, with successful genotyping of 594 BD cases and 1421 healthy controls. We found no significant association after multiple-testing correction between any of these SNPs and BD in our sample. Thus, it is unlikely that these genetic variations confer susceptibility to BD in this large Scandinavian sample.
U2 - 10.1097/YPG.0b013e32832d302f
DO - 10.1097/YPG.0b013e32832d302f
M3 - Journal article
C2 - 19478689
VL - 19
SP - 269
EP - 272
JO - Psychiatric Genetics
JF - Psychiatric Genetics
SN - 0955-8829
IS - 5
ER -
ID: 13861474