New insights to the crosstalk between vascular and bone tissue in chronic kidney disease–mineral and bone disorder
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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New insights to the crosstalk between vascular and bone tissue in chronic kidney disease–mineral and bone disorder. / Mace, Maria L.; Egstrand, Søren; Morevati, Marya; Olgaard, Klaus; Lewin, Ewa.
I: Metabolites, Bind 11, Nr. 12, 849, 2021.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - New insights to the crosstalk between vascular and bone tissue in chronic kidney disease–mineral and bone disorder
AU - Mace, Maria L.
AU - Egstrand, Søren
AU - Morevati, Marya
AU - Olgaard, Klaus
AU - Lewin, Ewa
N1 - Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021
Y1 - 2021
N2 - Vasculature plays a key role in bone development and the maintenance of bone tissue throughout life. The two organ systems are not only linked in normal physiology, but also in pathophysiological conditions. The chronic kidney disease–mineral and bone disorder (CKD-MBD) is still the most serious complication to CKD, resulting in increased morbidity and mortality. Current treatment therapies aimed at the phosphate retention and parathyroid hormone disturbances fail to reduce the high cardiovascular mortality in CKD patients, underlining the importance of other factors in the complex syndrome. This review will focus on vascular disease and its interplay with bone disorders in CKD. It will present the very late data showing a direct effect of vascular calcification on bone metabolism, indicating a vascular-bone tissue crosstalk in CKD. The calcified vasculature not only suffers from the systemic effects of CKD but seems to be an active player in the CKD-MBD syndrome impairing bone metabolism and might be a novel target for treatment and prevention.
AB - Vasculature plays a key role in bone development and the maintenance of bone tissue throughout life. The two organ systems are not only linked in normal physiology, but also in pathophysiological conditions. The chronic kidney disease–mineral and bone disorder (CKD-MBD) is still the most serious complication to CKD, resulting in increased morbidity and mortality. Current treatment therapies aimed at the phosphate retention and parathyroid hormone disturbances fail to reduce the high cardiovascular mortality in CKD patients, underlining the importance of other factors in the complex syndrome. This review will focus on vascular disease and its interplay with bone disorders in CKD. It will present the very late data showing a direct effect of vascular calcification on bone metabolism, indicating a vascular-bone tissue crosstalk in CKD. The calcified vasculature not only suffers from the systemic effects of CKD but seems to be an active player in the CKD-MBD syndrome impairing bone metabolism and might be a novel target for treatment and prevention.
KW - Activin A
KW - Dickkopf-1
KW - Renal osteodystrophy
KW - Sclerostin
KW - TGF-β signaling
KW - Tissue crosstalk
KW - Uremic vasculopathy
KW - Vascular calcification
KW - Wnt pathway
U2 - 10.3390/metabo11120849
DO - 10.3390/metabo11120849
M3 - Review
C2 - 34940607
AN - SCOPUS:85121756735
VL - 11
JO - Metabolites
JF - Metabolites
SN - 2218-1989
IS - 12
M1 - 849
ER -
ID: 303766497