TY - JOUR

T1 - New aspects of the kidney in the regulation of fibroblast growth factor 23 (Fgf23) and mineral homeostasis

AU - Mace, Maria L.

AU - Olgaard, Klaus

AU - Lewin, Ewa

PY - 2020

Y1 - 2020

N2 - The bone‐derived hormone fibroblast growth factor 23 (FGF23) acts in concert with parathyroid hormone (PTH) and the active vitamin D metabolite calcitriol in the regulation of calcium (Ca) and phosphate (P) homeostasis. More factors are being identified to regulate FGF23 levels and the endocrine loops between the three hormones. The present review summarizes the complex regulation of FGF23 and the disturbed FGF23/Klotho system in chronic kidney disease (CKD). In addition to the reduced ability of the injured kidney to regulate plasma levels of FGF23, several CKD‐related factors have been shown to stimulate FGF23 production. The high circulating FGF23 levels have detrimental effects on erythropoiesis, the cardio‐vascular system and the immune system, all contributing to the disturbed system biology in CKD. Moreover, new factors secreted by the injured kidney and the uremic calcified vasculature play a role in the mineral and bone disorder in CKD and create a vicious pathological crosstalk.

AB - The bone‐derived hormone fibroblast growth factor 23 (FGF23) acts in concert with parathyroid hormone (PTH) and the active vitamin D metabolite calcitriol in the regulation of calcium (Ca) and phosphate (P) homeostasis. More factors are being identified to regulate FGF23 levels and the endocrine loops between the three hormones. The present review summarizes the complex regulation of FGF23 and the disturbed FGF23/Klotho system in chronic kidney disease (CKD). In addition to the reduced ability of the injured kidney to regulate plasma levels of FGF23, several CKD‐related factors have been shown to stimulate FGF23 production. The high circulating FGF23 levels have detrimental effects on erythropoiesis, the cardio‐vascular system and the immune system, all contributing to the disturbed system biology in CKD. Moreover, new factors secreted by the injured kidney and the uremic calcified vasculature play a role in the mineral and bone disorder in CKD and create a vicious pathological crosstalk.

KW - Activin A

KW - Acute kidney failure

KW - Bone

KW - Calcitriol

KW - Calcium

KW - Chronic kidney failure

KW - Circadian rhythm

KW - CKD‐MBD

KW - Crosstalk

KW - Klotho

KW - Phosphate

KW - PTH

U2 - 10.3390/ijms21228810

DO - 10.3390/ijms21228810

M3 - Review

C2 - 33233840

AN - SCOPUS:85096312793

VL - 21

SP - 1

EP - 20

JO - International Journal of Molecular Sciences (Online)

JF - International Journal of Molecular Sciences (Online)

SN - 1661-6596

IS - 22

M1 - 8810

ER -