Neurosyphilis among people with and without HIV infection: A Danish nationwide prospective, population-based cohort study 2015–2021
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Neurosyphilis among people with and without HIV infection : A Danish nationwide prospective, population-based cohort study 2015–2021. / Schnohr, Christina Carolina Steenberg; Paulsen, Fie Welling; Larsen, Lykke; Storgaard, Merete; Jepsen, Micha Phill Grønholm; Lüttichau, Hans Rudolf; Wiese, Lothar; Hansen, Birgitte Rønde; Bodilsen, Jacob; Nielsen, Henrik; Lebech, Anne-Mette; Omland, Lars Haukali.
I: Journal of Infection, Bind 86, Nr. 5, 2023, s. 439-445.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Neurosyphilis among people with and without HIV infection
T2 - A Danish nationwide prospective, population-based cohort study 2015–2021
AU - Schnohr, Christina Carolina Steenberg
AU - Paulsen, Fie Welling
AU - Larsen, Lykke
AU - Storgaard, Merete
AU - Jepsen, Micha Phill Grønholm
AU - Lüttichau, Hans Rudolf
AU - Wiese, Lothar
AU - Hansen, Birgitte Rønde
AU - Bodilsen, Jacob
AU - Nielsen, Henrik
AU - Lebech, Anne-Mette
AU - Omland, Lars Haukali
N1 - Publisher Copyright: © 2023 The Authors
PY - 2023
Y1 - 2023
N2 - Background: Comparative data on clinical presentation, laboratory characteristics, treatment, and outcome of neurosyphilis (NS) in people living with HIV (PLWH) and NS patients without HIV are scarce. Methods: Nationwide, population-based, prospective cohort study on all adults with NS diagnosed between 2015 and 2021 at departments of infectious diseases in Denmark. Results: We identified 108 patients with NS, which equals a yearly incidence of 0.3/100,000 adults. The median age was 49 years, 85 (79%) were male, 43 (40%) were men having sex with men and 20 (22%) were PLWH. Ninety-five (88%) had early NS, 37 (34%) had ocular or ocular and otogenic NS, and 27 (25%) had symptomatic meningitis. Most common symptoms were visual disturbance (44%), skin rash (40%), fatigue (26%) and chancre (17%). Median CSF leukocyte count was 27 × 106 cells/L. PLWH less often had neurological deficits (p = 0.02). Unfavorable outcome was observed in 23 (21%) at discharge of whom 0 were PLWH (p = 0.01). Among the 88 NS patients without HIV a CSF leukocyte count of ≥ 30 × 106 cells/L was associated with unfavorable outcome (OR = 3.3 (95% confidence interval: 1.1–10.4)). Conclusions: PLWH with NS have better outcomes than NS patients without HIV infection.
AB - Background: Comparative data on clinical presentation, laboratory characteristics, treatment, and outcome of neurosyphilis (NS) in people living with HIV (PLWH) and NS patients without HIV are scarce. Methods: Nationwide, population-based, prospective cohort study on all adults with NS diagnosed between 2015 and 2021 at departments of infectious diseases in Denmark. Results: We identified 108 patients with NS, which equals a yearly incidence of 0.3/100,000 adults. The median age was 49 years, 85 (79%) were male, 43 (40%) were men having sex with men and 20 (22%) were PLWH. Ninety-five (88%) had early NS, 37 (34%) had ocular or ocular and otogenic NS, and 27 (25%) had symptomatic meningitis. Most common symptoms were visual disturbance (44%), skin rash (40%), fatigue (26%) and chancre (17%). Median CSF leukocyte count was 27 × 106 cells/L. PLWH less often had neurological deficits (p = 0.02). Unfavorable outcome was observed in 23 (21%) at discharge of whom 0 were PLWH (p = 0.01). Among the 88 NS patients without HIV a CSF leukocyte count of ≥ 30 × 106 cells/L was associated with unfavorable outcome (OR = 3.3 (95% confidence interval: 1.1–10.4)). Conclusions: PLWH with NS have better outcomes than NS patients without HIV infection.
KW - Antibiotic therapy
KW - HIV
KW - Neurosyphilis
KW - Syphilis
U2 - 10.1016/j.jinf.2023.03.019
DO - 10.1016/j.jinf.2023.03.019
M3 - Journal article
C2 - 36967087
AN - SCOPUS:85151491732
VL - 86
SP - 439
EP - 445
JO - Journal of Infection
JF - Journal of Infection
SN - 0163-4453
IS - 5
ER -
ID: 362458484