TY - JOUR

T1 - Neural correlates of executive attention in adults born very preterm

AU - Daamen, Marcel

AU - Bäuml, Josef G.

AU - Scheef, Lukas

AU - Meng, Chun

AU - Jurcoane, Alina

AU - Jaekel, Julia

AU - Sorg, Christian

AU - Busch, Barbara

AU - Baumann, Nicole

AU - Bartmann, Peter

AU - Wolke, Dieter

AU - Wohlschläger, Afra

AU - Boecker, Henning

N1 - Publisher Copyright: © 2015 The Authors. Published by Elsevier Inc.

PY - 2015

Y1 - 2015

N2 - Very preterm birth is associated with an increased prevalence of attention problems and may especially impair executive attention, i.e., top-down control of attentional selection in situations where distracting information interferes with the processing of task-relevant stimuli. While there are initial findings linking structural brain alterations in preterm-born individuals with attention problems, the functional basis of these problems are not well understood. The present study used an fMRI adaptation of the Attentional Network Test to examine the neural correlates of executive attention in a large sample of N = 86 adults born very preterm and/or with very low birth weight (VP/VLBW), and N = 100 term-born controls. Executive attention was measured by comparing task behavior and brain activations associated with the processing of incongruent vs. congruent arrow flanker stimuli. Consistent with subtle impairments of executive attention, the VP/VLBW group showed lower accuracy and a tendency for increased response times during the processing of incongruent stimuli. Both groups showed similar activation patters, especially within expected fronto-cingulo-parietal areas, but no significant between-group differences. Our results argue for a maintained attention-relevant network organization in high-functioning preterm born adults in spite of subtle deficits in executive attention. Gestational age and neonatal treatment variables showed associations with task behavior, and brain activation in the dorsal ACC and lateral occipital areas, suggesting that the degree of prematurity (and related neonatal complications) has subtle modulatory influences on executive attention processing.

AB - Very preterm birth is associated with an increased prevalence of attention problems and may especially impair executive attention, i.e., top-down control of attentional selection in situations where distracting information interferes with the processing of task-relevant stimuli. While there are initial findings linking structural brain alterations in preterm-born individuals with attention problems, the functional basis of these problems are not well understood. The present study used an fMRI adaptation of the Attentional Network Test to examine the neural correlates of executive attention in a large sample of N = 86 adults born very preterm and/or with very low birth weight (VP/VLBW), and N = 100 term-born controls. Executive attention was measured by comparing task behavior and brain activations associated with the processing of incongruent vs. congruent arrow flanker stimuli. Consistent with subtle impairments of executive attention, the VP/VLBW group showed lower accuracy and a tendency for increased response times during the processing of incongruent stimuli. Both groups showed similar activation patters, especially within expected fronto-cingulo-parietal areas, but no significant between-group differences. Our results argue for a maintained attention-relevant network organization in high-functioning preterm born adults in spite of subtle deficits in executive attention. Gestational age and neonatal treatment variables showed associations with task behavior, and brain activation in the dorsal ACC and lateral occipital areas, suggesting that the degree of prematurity (and related neonatal complications) has subtle modulatory influences on executive attention processing.

KW - Anterior cingulate

KW - Attentional Network Test

KW - Executive attention

KW - Gestational age

KW - Preterm birth

UR - http://www.scopus.com/inward/record.url?scp=84945305108&partnerID=8YFLogxK

U2 - 10.1016/j.nicl.2015.09.002

DO - 10.1016/j.nicl.2015.09.002

M3 - Journal article

C2 - 26640769

AN - SCOPUS:84945305108

VL - 9

SP - 581

EP - 591

JO - NeuroImage: Clinical

JF - NeuroImage: Clinical

SN - 2213-1582

ER -