Nedd8 processing enzymes in Schizosaccharomyces pombe
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Conjugation of the ubiquitin-like modifier Nedd8 to cullins is critical for the function of SCF-type ubiquitin ligases and thus facilitates ubiquitin conjugation and ultimately degradation of SCF substrates, including several cell cycle regulators. Like ubiquitin, Nedd8 is produced as a precursor that must first be processed before it becomes active. In Saccharomyces cerevisiae this is carried out exclusively by the enzyme Yuh1.
Originalsprog | Engelsk |
---|---|
Tidsskrift | B M C Biochemistry |
Vol/bind | 14 |
Udgave nummer | 8 |
Sider (fra-til) | 1-6 |
Antal sider | 6 |
ISSN | 1471-2091 |
DOI | |
Status | Udgivet - 2013 |
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ID: 47230163