Natural CD4+ T-cell responses against indoleamine 2,3-dioxygenase
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Natural CD4+ T-cell responses against indoleamine 2,3-dioxygenase. / Munir, Shamaila; Larsen, Stine Kiaer; Iversen, Trine Zeeberg; Donia, Marco; Klausen, Tobias Wirenfeldt; Svane, Inge Marie; Straten, Per Thor; Andersen, Mads Hald.
I: P L o S One, Bind 7, Nr. 4, 2012, s. e34568.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Natural CD4+ T-cell responses against indoleamine 2,3-dioxygenase
AU - Munir, Shamaila
AU - Larsen, Stine Kiaer
AU - Iversen, Trine Zeeberg
AU - Donia, Marco
AU - Klausen, Tobias Wirenfeldt
AU - Svane, Inge Marie
AU - Straten, Per Thor
AU - Andersen, Mads Hald
PY - 2012
Y1 - 2012
N2 - The enzyme indoleamine 2,3-dioxygenase (IDO) contributes to immune tolerance in a variety of settings. In cancer IDO is expressed within the tumor itself as well as in antigen-presenting cells in tumor-draining lymph nodes, where it endorses the establishment of peripheral immune tolerance to tumor antigens. Recently, we described cytotoxic CD8(+) T-cell reactivity towards IDO-derived peptides.
AB - The enzyme indoleamine 2,3-dioxygenase (IDO) contributes to immune tolerance in a variety of settings. In cancer IDO is expressed within the tumor itself as well as in antigen-presenting cells in tumor-draining lymph nodes, where it endorses the establishment of peripheral immune tolerance to tumor antigens. Recently, we described cytotoxic CD8(+) T-cell reactivity towards IDO-derived peptides.
U2 - 10.1371/journal.pone.0034568
DO - 10.1371/journal.pone.0034568
M3 - Journal article
VL - 7
SP - e34568
JO - PLoS ONE
JF - PLoS ONE
SN - 1932-6203
IS - 4
ER -
ID: 48579989