Narcolepsy as an autoimmune disease

Narcolepsy as an autoimmune disease: the role of H1N1 infection and vaccination

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Standard

Narcolepsy as an autoimmune disease : the role of H1N1 infection and vaccination. / Partinen, Markku; Kornum, Birgitte Rahbek; Plazzi, Giuseppe; Jennum, Poul; Julkunen, Ilkka; Vaarala, Outi.

I: Lancet Neurology, Bind 13, Nr. 6, 2014, s. 600-13.

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Harvard

Partinen, M, Kornum, BR, Plazzi, G, Jennum, P, Julkunen, I & Vaarala, O 2014, 'Narcolepsy as an autoimmune disease: the role of H1N1 infection and vaccination', Lancet Neurology, bind 13, nr. 6, s. 600-13. https://doi.org/10.1016/S1474-4422(14)70075-4

APA

Partinen, M., Kornum, B. R., Plazzi, G., Jennum, P., Julkunen, I., & Vaarala, O. (2014). Narcolepsy as an autoimmune disease: the role of H1N1 infection and vaccination. Lancet Neurology, 13(6), 600-13. https://doi.org/10.1016/S1474-4422(14)70075-4

Vancouver

Partinen M, Kornum BR, Plazzi G, Jennum P, Julkunen I, Vaarala O. Narcolepsy as an autoimmune disease: the role of H1N1 infection and vaccination. Lancet Neurology. 2014;13(6):600-13. https://doi.org/10.1016/S1474-4422(14)70075-4

Author

Partinen, Markku ; Kornum, Birgitte Rahbek ; Plazzi, Giuseppe ; Jennum, Poul ; Julkunen, Ilkka ; Vaarala, Outi. / Narcolepsy as an autoimmune disease : the role of H1N1 infection and vaccination. I: Lancet Neurology. 2014 ; Bind 13, Nr. 6. s. 600-13.

Bibtex

@article{2b4cc016504c4fd3b240928b8045ee5e,

title = "Narcolepsy as an autoimmune disease: the role of H1N1 infection and vaccination",

abstract = "Narcolepsy is a sleep disorder characterised by loss of hypothalamic hypocretin (orexin) neurons. The prevalence of narcolepsy is about 30 per 100 000 people, and typical age at onset is 12-16 years. Narcolepsy is strongly associated with the HLA-DQB1*06:02 genotype, and has been thought of as an immune-mediated disease. Other risk genes, such as T-cell-receptor α chain and purinergic receptor subtype 2Y11, are also implicated. Interest in narcolepsy has increased since the epidemiological observations that H1N1 infection and vaccination are potential triggering factors, and an increase in the incidence of narcolepsy after the pandemic AS03 adjuvanted H1N1 vaccination in 2010 from Sweden and Finland supports the immune-mediated pathogenesis. Epidemiological observations from studies in China also suggest a role for H1N1 virus infections as a trigger for narcolepsy. Although the pathological mechanisms are unknown, an H1N1 virus-derived antigen might be the trigger. ",

keywords = "Autoimmune Diseases of the Nervous System/epidemiology, Humans, Influenza A Virus, H1N1 Subtype/immunology, Influenza, Human/complications, Narcolepsy/epidemiology, Vaccination/adverse effects",

author = "Markku Partinen and Kornum, {Birgitte Rahbek} and Giuseppe Plazzi and Poul Jennum and Ilkka Julkunen and Outi Vaarala",

year = "2014",

doi = "10.1016/S1474-4422(14)70075-4",

language = "English",

volume = "13",

pages = "600--13",

journal = "The Lancet Neurology",

issn = "1474-4422",

publisher = "TheLancet Publishing Group",

number = "6",

}

RIS

TY - JOUR

T1 - Narcolepsy as an autoimmune disease

T2 - the role of H1N1 infection and vaccination

AU - Partinen, Markku

AU - Kornum, Birgitte Rahbek

AU - Plazzi, Giuseppe

AU - Jennum, Poul

AU - Julkunen, Ilkka

AU - Vaarala, Outi

PY - 2014

Y1 - 2014

N2 - Narcolepsy is a sleep disorder characterised by loss of hypothalamic hypocretin (orexin) neurons. The prevalence of narcolepsy is about 30 per 100 000 people, and typical age at onset is 12-16 years. Narcolepsy is strongly associated with the HLA-DQB1*06:02 genotype, and has been thought of as an immune-mediated disease. Other risk genes, such as T-cell-receptor α chain and purinergic receptor subtype 2Y11, are also implicated. Interest in narcolepsy has increased since the epidemiological observations that H1N1 infection and vaccination are potential triggering factors, and an increase in the incidence of narcolepsy after the pandemic AS03 adjuvanted H1N1 vaccination in 2010 from Sweden and Finland supports the immune-mediated pathogenesis. Epidemiological observations from studies in China also suggest a role for H1N1 virus infections as a trigger for narcolepsy. Although the pathological mechanisms are unknown, an H1N1 virus-derived antigen might be the trigger.

AB - Narcolepsy is a sleep disorder characterised by loss of hypothalamic hypocretin (orexin) neurons. The prevalence of narcolepsy is about 30 per 100 000 people, and typical age at onset is 12-16 years. Narcolepsy is strongly associated with the HLA-DQB1*06:02 genotype, and has been thought of as an immune-mediated disease. Other risk genes, such as T-cell-receptor α chain and purinergic receptor subtype 2Y11, are also implicated. Interest in narcolepsy has increased since the epidemiological observations that H1N1 infection and vaccination are potential triggering factors, and an increase in the incidence of narcolepsy after the pandemic AS03 adjuvanted H1N1 vaccination in 2010 from Sweden and Finland supports the immune-mediated pathogenesis. Epidemiological observations from studies in China also suggest a role for H1N1 virus infections as a trigger for narcolepsy. Although the pathological mechanisms are unknown, an H1N1 virus-derived antigen might be the trigger.

KW - Autoimmune Diseases of the Nervous System/epidemiology

KW - Humans

KW - Influenza A Virus, H1N1 Subtype/immunology

KW - Influenza, Human/complications

KW - Narcolepsy/epidemiology

KW - Vaccination/adverse effects

U2 - 10.1016/S1474-4422(14)70075-4

DO - 10.1016/S1474-4422(14)70075-4

M3 - Review

C2 - 24849861

VL - 13

SP - 600

EP - 613

JO - The Lancet Neurology

JF - The Lancet Neurology

SN - 1474-4422

IS - 6

ER -

ID: 196168607