NANOG reporter cell lines generated by gene targeting in human embryonic stem cells
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Pluripotency and self-renewal of human embryonic stem cells (hESCs) is mediated by a complex interplay between extra- and intracellular signaling pathways, which regulate the expression of pluripotency-specific transcription factors. The homeodomain transcription factor NANOG plays a central role in maintaining hESC pluripotency, but the precise role and regulation of NANOG are not well defined.
Originalsprog | Engelsk |
---|---|
Tidsskrift | P L o S One |
Vol/bind | 5 |
Udgave nummer | 9 |
ISSN | 1932-6203 |
DOI | |
Status | Udgivet - 2010 |
ID: 46463268