NANOG reporter cell lines generated by gene targeting in human embryonic stem cells
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NANOG reporter cell lines generated by gene targeting in human embryonic stem cells. / Fischer, Yvonne; Ganic, Elvira; Ameri, Jacqueline; Xian, Xiaojie; Johannesson, Martina; Semb, Tor Henrik.
I: P L o S One, Bind 5, Nr. 9, 2010.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - NANOG reporter cell lines generated by gene targeting in human embryonic stem cells
AU - Fischer, Yvonne
AU - Ganic, Elvira
AU - Ameri, Jacqueline
AU - Xian, Xiaojie
AU - Johannesson, Martina
AU - Semb, Tor Henrik
PY - 2010
Y1 - 2010
N2 - Pluripotency and self-renewal of human embryonic stem cells (hESCs) is mediated by a complex interplay between extra- and intracellular signaling pathways, which regulate the expression of pluripotency-specific transcription factors. The homeodomain transcription factor NANOG plays a central role in maintaining hESC pluripotency, but the precise role and regulation of NANOG are not well defined.
AB - Pluripotency and self-renewal of human embryonic stem cells (hESCs) is mediated by a complex interplay between extra- and intracellular signaling pathways, which regulate the expression of pluripotency-specific transcription factors. The homeodomain transcription factor NANOG plays a central role in maintaining hESC pluripotency, but the precise role and regulation of NANOG are not well defined.
KW - Cell Line
KW - Embryonic Stem Cells
KW - Gene Expression Regulation
KW - Gene Targeting
KW - Genes, Reporter
KW - Homeodomain Proteins
KW - Humans
U2 - 10.1371/journal.pone.0012533
DO - 10.1371/journal.pone.0012533
M3 - Journal article
C2 - 20824089
VL - 5
JO - PLoS ONE
JF - PLoS ONE
SN - 1932-6203
IS - 9
ER -
ID: 46463268