Myoepithelial cells: their origin and function in breast morphogenesis and neoplasia
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Myoepithelial cells: their origin and function in breast morphogenesis and neoplasia. / Gudjonsson, Thorarinn; Adriance, Melissa C; Sternlicht, Mark D; Petersen, Ole W; Bissell, Mina J.
I: Journal of Mammary Gland Biology and Neoplasia, Bind 10, Nr. 3, 07.2005, s. 261-72.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Myoepithelial cells: their origin and function in breast morphogenesis and neoplasia
AU - Gudjonsson, Thorarinn
AU - Adriance, Melissa C
AU - Sternlicht, Mark D
AU - Petersen, Ole W
AU - Bissell, Mina J
N1 - Keywords: Animals; Breast Neoplasms; Cell Differentiation; Cell Lineage; Cell Polarity; Cell Transformation, Neoplastic; Epithelial Cells; Female; Humans; Mammary Glands, Human; Morphogenesis; Stem Cells; Tumor Markers, Biological
PY - 2005/7
Y1 - 2005/7
N2 - The human breast epithelium is a branching ductal system composed of an inner layer of polarized luminal epithelial cells and an outer layer of myoepithelial cells that terminate in distally located terminal duct lobular units (TDLUs). While the luminal epithelial cell has received the most attention as the functionally active milk-producing cell and as the most likely target cell for carcinogenesis, attention on myoepithelial cells has begun to evolve with the recognition that these cells play an active part in branching morphogenesis and tumor suppression. A major question that has been the subject of investigation pertains to how the luminal epithelial and myoepithelial lineages are related and precisely how they arise from a common putative stem cell population within the breast. Equally important is the question of how heterotypic signaling occurs between luminal epithelial and surrounding myoepithelial cells in normal breast morphogenesis and neoplasia. In this review we discuss data from our laboratories and from others regarding the cellular origin of human myoepithelial cells, their function in maintaining tissue polarity in the normal breast, and their role during neoplasia.
AB - The human breast epithelium is a branching ductal system composed of an inner layer of polarized luminal epithelial cells and an outer layer of myoepithelial cells that terminate in distally located terminal duct lobular units (TDLUs). While the luminal epithelial cell has received the most attention as the functionally active milk-producing cell and as the most likely target cell for carcinogenesis, attention on myoepithelial cells has begun to evolve with the recognition that these cells play an active part in branching morphogenesis and tumor suppression. A major question that has been the subject of investigation pertains to how the luminal epithelial and myoepithelial lineages are related and precisely how they arise from a common putative stem cell population within the breast. Equally important is the question of how heterotypic signaling occurs between luminal epithelial and surrounding myoepithelial cells in normal breast morphogenesis and neoplasia. In this review we discuss data from our laboratories and from others regarding the cellular origin of human myoepithelial cells, their function in maintaining tissue polarity in the normal breast, and their role during neoplasia.
U2 - 10.1007/s10911-005-9586-4
DO - 10.1007/s10911-005-9586-4
M3 - Review
C2 - 16807805
VL - 10
SP - 261
EP - 272
JO - Journal of Mammary Gland Biology and Neoplasia
JF - Journal of Mammary Gland Biology and Neoplasia
SN - 1083-3021
IS - 3
ER -
ID: 10513019