MYC mRNA expression throughout the intestine is not associated with body mass index or type 2 diabetes
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MYC mRNA expression throughout the intestine is not associated with body mass index or type 2 diabetes. / Ellegaard, Anne-Marie; Knop, Filip Krag.
I: Endocrinology, Diabetes and Metabolism, Bind 5, Nr. 2, 00327, 2022.Publikation: Bidrag til tidsskrift › Kommentar/debat › Forskning
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TY - JOUR
T1 - MYC mRNA expression throughout the intestine is not associated with body mass index or type 2 diabetes
AU - Ellegaard, Anne-Marie
AU - Knop, Filip Krag
PY - 2022
Y1 - 2022
N2 - Inspired by the prospect of intestinal MYC reduction as a putative drug target against metabolic disorders, we investigated MYC mRNA expression in intestinal mucosa biopsies sampled using double-balloon enteroscopy along the entire intestinal tract of 12 patients with type 2 diabetes and 12 matched healthy controls. In these individuals with body mass index (BMI) ranging from 20 to 31 kg/m(2), the mean MYC mRNA expression varied along the intestine with the lowest level observed at the distal small intestine and the greatest expression levels in the proximal small intestine and in the colon. We do not see a correlation between intestinal mucosal MYC mRNA expression and BMI or glycaemic control, and thus, our findings do not support the hypothesis of intestinal MYC as a putative drug target against obesity and metabolic diseases.
AB - Inspired by the prospect of intestinal MYC reduction as a putative drug target against metabolic disorders, we investigated MYC mRNA expression in intestinal mucosa biopsies sampled using double-balloon enteroscopy along the entire intestinal tract of 12 patients with type 2 diabetes and 12 matched healthy controls. In these individuals with body mass index (BMI) ranging from 20 to 31 kg/m(2), the mean MYC mRNA expression varied along the intestine with the lowest level observed at the distal small intestine and the greatest expression levels in the proximal small intestine and in the colon. We do not see a correlation between intestinal mucosal MYC mRNA expression and BMI or glycaemic control, and thus, our findings do not support the hypothesis of intestinal MYC as a putative drug target against obesity and metabolic diseases.
KW - mRNA expression
KW - obesity
KW - type 2 diabetes
U2 - 10.1002/edm2.327
DO - 10.1002/edm2.327
M3 - Comment/debate
C2 - 35182044
VL - 5
JO - Endocrinology, Diabetes and Metabolism
JF - Endocrinology, Diabetes and Metabolism
SN - 2398-9238
IS - 2
M1 - 00327
ER -
ID: 298982220