Multiple sclerosis and polymorphisms of innate pattern recognition receptors TLR1-10, NOD1-2, DDX58, and IFIH1

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Standard

Multiple sclerosis and polymorphisms of innate pattern recognition receptors TLR1-10, NOD1-2, DDX58, and IFIH1. / Enevold, Christian; Oturai, Annette Bang; Sørensen, Per Soelberg; Ryder, Lars Peter; Koch-Henriksen, Nils; Bendtzen, Klaus.

I: Journal of Neuroimmunology, Bind 212, Nr. 1-2, 25.07.2009, s. 125-31.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Enevold, C, Oturai, AB, Sørensen, PS, Ryder, LP, Koch-Henriksen, N & Bendtzen, K 2009, 'Multiple sclerosis and polymorphisms of innate pattern recognition receptors TLR1-10, NOD1-2, DDX58, and IFIH1', Journal of Neuroimmunology, bind 212, nr. 1-2, s. 125-31. https://doi.org/10.1016/j.jneuroim.2009.04.008, https://doi.org/10.1016/j.jneuroim.2009.04.008

APA

Enevold, C., Oturai, A. B., Sørensen, P. S., Ryder, L. P., Koch-Henriksen, N., & Bendtzen, K. (2009). Multiple sclerosis and polymorphisms of innate pattern recognition receptors TLR1-10, NOD1-2, DDX58, and IFIH1. Journal of Neuroimmunology, 212(1-2), 125-31. https://doi.org/10.1016/j.jneuroim.2009.04.008, https://doi.org/10.1016/j.jneuroim.2009.04.008

Vancouver

Enevold C, Oturai AB, Sørensen PS, Ryder LP, Koch-Henriksen N, Bendtzen K. Multiple sclerosis and polymorphisms of innate pattern recognition receptors TLR1-10, NOD1-2, DDX58, and IFIH1. Journal of Neuroimmunology. 2009 jul. 25;212(1-2):125-31. https://doi.org/10.1016/j.jneuroim.2009.04.008, https://doi.org/10.1016/j.jneuroim.2009.04.008

Author

Enevold, Christian ; Oturai, Annette Bang ; Sørensen, Per Soelberg ; Ryder, Lars Peter ; Koch-Henriksen, Nils ; Bendtzen, Klaus. / Multiple sclerosis and polymorphisms of innate pattern recognition receptors TLR1-10, NOD1-2, DDX58, and IFIH1. I: Journal of Neuroimmunology. 2009 ; Bind 212, Nr. 1-2. s. 125-31.

Bibtex

@article{d1bb086061b311df928f000ea68e967b,
title = "Multiple sclerosis and polymorphisms of innate pattern recognition receptors TLR1-10, NOD1-2, DDX58, and IFIH1",
abstract = "Genetic factors are critical in multiple sclerosis (MS), and it is conceivable that the pattern recognition receptors of the innate immune system are of pathogenic importance. We therefore developed two novel assays capable of analyzing 42 single-nucleotide polymorphisms in the human genes encoding TLR1-10, NOD1-2, DDX58, and IFIH1. Using these assays, we genotyped 963 MS patients and 960 controls, and analyzed for possible associations to MS diagnosis, clinical course, severity, and age at onset. Our results support previous findings of associations between the IFIH1-locus and MS (IFIH1-rs3747517 and IFIH1-rs1990760 trend test: P=0.002 and P=0.014, respectively).",
author = "Christian Enevold and Oturai, {Annette Bang} and S{\o}rensen, {Per Soelberg} and Ryder, {Lars Peter} and Nils Koch-Henriksen and Klaus Bendtzen",
year = "2009",
month = jul,
day = "25",
doi = "10.1016/j.jneuroim.2009.04.008",
language = "English",
volume = "212",
pages = "125--31",
journal = "Journal of Neuroimmunology",
issn = "0165-5728",
publisher = "Elsevier",
number = "1-2",

}

RIS

TY - JOUR

T1 - Multiple sclerosis and polymorphisms of innate pattern recognition receptors TLR1-10, NOD1-2, DDX58, and IFIH1

AU - Enevold, Christian

AU - Oturai, Annette Bang

AU - Sørensen, Per Soelberg

AU - Ryder, Lars Peter

AU - Koch-Henriksen, Nils

AU - Bendtzen, Klaus

PY - 2009/7/25

Y1 - 2009/7/25

N2 - Genetic factors are critical in multiple sclerosis (MS), and it is conceivable that the pattern recognition receptors of the innate immune system are of pathogenic importance. We therefore developed two novel assays capable of analyzing 42 single-nucleotide polymorphisms in the human genes encoding TLR1-10, NOD1-2, DDX58, and IFIH1. Using these assays, we genotyped 963 MS patients and 960 controls, and analyzed for possible associations to MS diagnosis, clinical course, severity, and age at onset. Our results support previous findings of associations between the IFIH1-locus and MS (IFIH1-rs3747517 and IFIH1-rs1990760 trend test: P=0.002 and P=0.014, respectively).

AB - Genetic factors are critical in multiple sclerosis (MS), and it is conceivable that the pattern recognition receptors of the innate immune system are of pathogenic importance. We therefore developed two novel assays capable of analyzing 42 single-nucleotide polymorphisms in the human genes encoding TLR1-10, NOD1-2, DDX58, and IFIH1. Using these assays, we genotyped 963 MS patients and 960 controls, and analyzed for possible associations to MS diagnosis, clinical course, severity, and age at onset. Our results support previous findings of associations between the IFIH1-locus and MS (IFIH1-rs3747517 and IFIH1-rs1990760 trend test: P=0.002 and P=0.014, respectively).

U2 - 10.1016/j.jneuroim.2009.04.008

DO - 10.1016/j.jneuroim.2009.04.008

M3 - Journal article

C2 - 19450885

VL - 212

SP - 125

EP - 131

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

SN - 0165-5728

IS - 1-2

ER -

ID: 19793914