Multiomic Analysis of the UV-Induced DNA Damage Response.

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Multiomic Analysis of the UV-Induced DNA Damage Response. / Boeing, S; Williamson, L; Encheva, V; Gori, I; Saunders, RE; Instrell, R; Aygün, O; Rodriguez-Martinez, M; Weems, JC; Kelly, GP; Conaway, JW; Conaway, RC; Svejstrup, JQ.

I: Cell Reports, Bind 15, Nr. 7, 2016, s. 1597-1610.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Boeing, S, Williamson, L, Encheva, V, Gori, I, Saunders, RE, Instrell, R, Aygün, O, Rodriguez-Martinez, M, Weems, JC, Kelly, GP, Conaway, JW, Conaway, RC & Svejstrup, JQ 2016, 'Multiomic Analysis of the UV-Induced DNA Damage Response.', Cell Reports, bind 15, nr. 7, s. 1597-1610. https://doi.org/10.1016/j.celrep.2016.04.047

APA

Boeing, S., Williamson, L., Encheva, V., Gori, I., Saunders, RE., Instrell, R., Aygün, O., Rodriguez-Martinez, M., Weems, JC., Kelly, GP., Conaway, JW., Conaway, RC., & Svejstrup, JQ. (2016). Multiomic Analysis of the UV-Induced DNA Damage Response. Cell Reports, 15(7), 1597-1610. https://doi.org/10.1016/j.celrep.2016.04.047

Vancouver

Boeing S, Williamson L, Encheva V, Gori I, Saunders RE, Instrell R o.a. Multiomic Analysis of the UV-Induced DNA Damage Response. Cell Reports. 2016;15(7):1597-1610. https://doi.org/10.1016/j.celrep.2016.04.047

Author

Boeing, S ; Williamson, L ; Encheva, V ; Gori, I ; Saunders, RE ; Instrell, R ; Aygün, O ; Rodriguez-Martinez, M ; Weems, JC ; Kelly, GP ; Conaway, JW ; Conaway, RC ; Svejstrup, JQ. / Multiomic Analysis of the UV-Induced DNA Damage Response. I: Cell Reports. 2016 ; Bind 15, Nr. 7. s. 1597-1610.

Bibtex

@article{de6752e29c4c4e8594366bf5067b49bd,
title = "Multiomic Analysis of the UV-Induced DNA Damage Response.",
abstract = "In order to facilitate the identification of factors and pathways in the cellular response to UV-induced DNA damage, several descriptive proteomic screens and a functional genomics screen were performed in parallel. Numerous factors could be identified with high confidence when the screen results were superimposed and interpreted together, incorporating biological knowledge. A searchable database, bioLOGIC, which provides access to relevant information about a protein or process of interest, was established to host the results and facilitate data mining. Besides uncovering roles in the DNA damage response for numerous proteins and complexes, including Integrator, Cohesin, PHF3, ASC-1, SCAF4, SCAF8, and SCAF11, we uncovered a role for the poorly studied, melanoma-associated serine/threonine kinase 19 (STK19). Besides effectively uncovering relevant factors, the multiomic approach also provides a systems-wide overview of the diverse cellular processes connected to the transcription-related DNA damage response.",
author = "S Boeing and L Williamson and V Encheva and I Gori and RE Saunders and R Instrell and O Ayg{\"u}n and M Rodriguez-Martinez and JC Weems and GP Kelly and JW Conaway and RC Conaway and JQ Svejstrup",
year = "2016",
doi = "10.1016/j.celrep.2016.04.047",
language = "Udefineret/Ukendt",
volume = "15",
pages = "1597--1610",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "7",

}

RIS

TY - JOUR

T1 - Multiomic Analysis of the UV-Induced DNA Damage Response.

AU - Boeing, S

AU - Williamson, L

AU - Encheva, V

AU - Gori, I

AU - Saunders, RE

AU - Instrell, R

AU - Aygün, O

AU - Rodriguez-Martinez, M

AU - Weems, JC

AU - Kelly, GP

AU - Conaway, JW

AU - Conaway, RC

AU - Svejstrup, JQ

PY - 2016

Y1 - 2016

N2 - In order to facilitate the identification of factors and pathways in the cellular response to UV-induced DNA damage, several descriptive proteomic screens and a functional genomics screen were performed in parallel. Numerous factors could be identified with high confidence when the screen results were superimposed and interpreted together, incorporating biological knowledge. A searchable database, bioLOGIC, which provides access to relevant information about a protein or process of interest, was established to host the results and facilitate data mining. Besides uncovering roles in the DNA damage response for numerous proteins and complexes, including Integrator, Cohesin, PHF3, ASC-1, SCAF4, SCAF8, and SCAF11, we uncovered a role for the poorly studied, melanoma-associated serine/threonine kinase 19 (STK19). Besides effectively uncovering relevant factors, the multiomic approach also provides a systems-wide overview of the diverse cellular processes connected to the transcription-related DNA damage response.

AB - In order to facilitate the identification of factors and pathways in the cellular response to UV-induced DNA damage, several descriptive proteomic screens and a functional genomics screen were performed in parallel. Numerous factors could be identified with high confidence when the screen results were superimposed and interpreted together, incorporating biological knowledge. A searchable database, bioLOGIC, which provides access to relevant information about a protein or process of interest, was established to host the results and facilitate data mining. Besides uncovering roles in the DNA damage response for numerous proteins and complexes, including Integrator, Cohesin, PHF3, ASC-1, SCAF4, SCAF8, and SCAF11, we uncovered a role for the poorly studied, melanoma-associated serine/threonine kinase 19 (STK19). Besides effectively uncovering relevant factors, the multiomic approach also provides a systems-wide overview of the diverse cellular processes connected to the transcription-related DNA damage response.

U2 - 10.1016/j.celrep.2016.04.047

DO - 10.1016/j.celrep.2016.04.047

M3 - Tidsskriftartikel

C2 - 27184836

VL - 15

SP - 1597

EP - 1610

JO - Cell Reports

JF - Cell Reports

SN - 2211-1247

IS - 7

ER -

ID: 331083528