Multimodal soft tissue markers for bridging high-resolution diagnostic imaging with therapeutic intervention
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Multimodal soft tissue markers for bridging high-resolution diagnostic imaging with therapeutic intervention. / Hansen, Anders E.; Henriksen, Jonas R.; Jølck, Rasmus I.; Fliedner, Frederikke P.; Bruun, Linda M.; Scherman, Jonas; Jensen, Andreas I.; Af Rosenschöld, Munck; Moorman, Lilah; Kurbegovic, Sorel; de Blanck, Steen R.; Larsen, Klaus R.; Clementsen, Paul F.; Christensen, Anders N.; Clausen, Mads H.; Wang, Wenbo; Kempen, Paul; Christensen, Merete; Viby, Niels Erik; Persson, Gitte; Larsen, Rasmus; Conradsen, Knut; McEvoy, Fintan J.; Kjaer, Andreas; Eriksen, Thomas; Andresen, Thomas L.
I: Science Advances, Bind 6, Nr. 34, eabb5353, 2020.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Multimodal soft tissue markers for bridging high-resolution diagnostic imaging with therapeutic intervention
AU - Hansen, Anders E.
AU - Henriksen, Jonas R.
AU - Jølck, Rasmus I.
AU - Fliedner, Frederikke P.
AU - Bruun, Linda M.
AU - Scherman, Jonas
AU - Jensen, Andreas I.
AU - Af Rosenschöld, Munck
AU - Moorman, Lilah
AU - Kurbegovic, Sorel
AU - de Blanck, Steen R.
AU - Larsen, Klaus R.
AU - Clementsen, Paul F.
AU - Christensen, Anders N.
AU - Clausen, Mads H.
AU - Wang, Wenbo
AU - Kempen, Paul
AU - Christensen, Merete
AU - Viby, Niels Erik
AU - Persson, Gitte
AU - Larsen, Rasmus
AU - Conradsen, Knut
AU - McEvoy, Fintan J.
AU - Kjaer, Andreas
AU - Eriksen, Thomas
AU - Andresen, Thomas L.
PY - 2020
Y1 - 2020
N2 - Diagnostic imaging often outperforms the surgeon's ability to identify small structures during therapeutic procedures. Smart soft tissue markers that translate the sensitivity of diagnostic imaging into optimal therapeutic intervention are therefore highly warranted. This paper presents a unique adaptable liquid soft tissue marker system based on functionalized carbohydrates (Carbo-gel). The liquid state of these markers allows for high-precision placement under image guidance using thin needles. Based on step-by-step modifications, the image features and mechanical properties of markers can be optimized to bridge diagnostic imaging and specific therapeutic interventions. The performance of Carbo-gel is demonstrated for markers that (i) have radiographic, magnetic resonance, and ultrasound visibility; (ii) are palpable and visible; and (iii) are localizable by near-infrared fluorescence and radio guidance. The study demonstrates encouraging proof of concept for the liquid marker system as a well-tolerated multimodal imaging marker that can improve image-guided radiotherapy and surgical interventions, including robotic surgery.
AB - Diagnostic imaging often outperforms the surgeon's ability to identify small structures during therapeutic procedures. Smart soft tissue markers that translate the sensitivity of diagnostic imaging into optimal therapeutic intervention are therefore highly warranted. This paper presents a unique adaptable liquid soft tissue marker system based on functionalized carbohydrates (Carbo-gel). The liquid state of these markers allows for high-precision placement under image guidance using thin needles. Based on step-by-step modifications, the image features and mechanical properties of markers can be optimized to bridge diagnostic imaging and specific therapeutic interventions. The performance of Carbo-gel is demonstrated for markers that (i) have radiographic, magnetic resonance, and ultrasound visibility; (ii) are palpable and visible; and (iii) are localizable by near-infrared fluorescence and radio guidance. The study demonstrates encouraging proof of concept for the liquid marker system as a well-tolerated multimodal imaging marker that can improve image-guided radiotherapy and surgical interventions, including robotic surgery.
U2 - 10.1126/sciadv.abb5353
DO - 10.1126/sciadv.abb5353
M3 - Journal article
C2 - 32875113
AN - SCOPUS:85090180117
VL - 6
JO - Science advances
JF - Science advances
SN - 2375-2548
IS - 34
M1 - eabb5353
ER -
ID: 250920355