Mucosal surface morphology and histological changes in the duodenum of the rat following administration of cysteamine
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Mucosal surface morphology and histological changes in the duodenum of the rat following administration of cysteamine. / Poulsen, Steen Seier; Szabo, S.
I: BRITISH JOURNAL OF EXPERIMENTAL PATHOLOGY, Bind 58, Nr. 1, 02.1977, s. 1-8.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Mucosal surface morphology and histological changes in the duodenum of the rat following administration of cysteamine
AU - Poulsen, Steen Seier
AU - Szabo, S
PY - 1977/2
Y1 - 1977/2
N2 - Acute duodenal ulcer can be produced in the rat by subcutaneous or oral administration of cysteamine. Development of this ulcer on the intestinal mucosal surface was followed from precursory stages to perforation using low power semimacroscopical and conventional histological techniques. The process started in the epithelium of the apical parts of the villi where segments of surface epithelial cells exfoliated and the lamina propria seemed to retract. As the process continued the villi gradually became lower eventually forming an avillous surface. Subsequently defects in the epithelium, necrosis, inflammation of the lamina propria, and a localized ulcer developed.
AB - Acute duodenal ulcer can be produced in the rat by subcutaneous or oral administration of cysteamine. Development of this ulcer on the intestinal mucosal surface was followed from precursory stages to perforation using low power semimacroscopical and conventional histological techniques. The process started in the epithelium of the apical parts of the villi where segments of surface epithelial cells exfoliated and the lamina propria seemed to retract. As the process continued the villi gradually became lower eventually forming an avillous surface. Subsequently defects in the epithelium, necrosis, inflammation of the lamina propria, and a localized ulcer developed.
KW - Animals
KW - Cysteamine
KW - Duodenal Ulcer
KW - Duodenum
KW - Female
KW - Intestinal Mucosa
KW - Rats
M3 - Journal article
C2 - 836762
VL - 58
SP - 1
EP - 8
JO - British Journal of Experimental Pathology
JF - British Journal of Experimental Pathology
SN - 0007-1021
IS - 1
ER -
ID: 47490247