Mortality and secular trend in the incidence of bipolar disorder
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Mortality and secular trend in the incidence of bipolar disorder. / Medici, Clara Reece; Videbech, Poul; Gustafsson, Lea Nørgreen; Munk-Jørgensen, Povl.
I: Journal of Affective Disorders, Bind 183, 01.09.2015, s. 39-44.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Mortality and secular trend in the incidence of bipolar disorder
AU - Medici, Clara Reece
AU - Videbech, Poul
AU - Gustafsson, Lea Nørgreen
AU - Munk-Jørgensen, Povl
N1 - Copyright © 2015 Elsevier B.V. All rights reserved.
PY - 2015/9/1
Y1 - 2015/9/1
N2 - BACKGROUND: The world-wide interest in bipolar disorder is illustrated by an exponential increase in publications on the disorder registered in Pubmed since 1990. This inspired an investigation of the epidemiology of bipolar disorder.METHODS: This was a register-based cohort study. All first-ever diagnoses of bipolar disorder (International Classification of Diseases-10: F31) were identified in the nationwide Danish Psychiatric Central Research Register between 1995 and 2012. Causes of death were obtained from The Danish Register of Causes of Death. Age- and gender standardized incidence rates, standardized mortality ratio (SMR) and Kaplan-Meier survival estimates were calculated.RESULTS: We identified 15,334 incident cases of bipolar disorder. The incidence rate increased from 18.5/100,000 person-years (PY) in 1995 to 28.4/100,000 PY in 2012. The mean age at time of diagnosis decreased significantly from 54.5 years in 1995 to 42.4 years in 2012 (p<0.001). The mean time from first affective diagnosis to diagnosis of bipolar disorder was 7.9 years (SD 9.1). The SMR was 1.7 (95%-CI 1.2-2.1). Causes of death were mainly natural; 9% died from suicide.LIMITATIONS: Only patients in psychiatric care were included. The outpatient registry opened in 1995. Patients treated solely in outpatient units are not recorded previously. Systematic studies validating all the clinical diagnoses of the registry do not exist.CONCLUSIONS: The incidence of bipolar disorder has increased in the last 10 years. The SMR was significantly increased. Half of the patients were known to have another affective disorder. This should be considered in future decisions regarding the healthcare organization.
AB - BACKGROUND: The world-wide interest in bipolar disorder is illustrated by an exponential increase in publications on the disorder registered in Pubmed since 1990. This inspired an investigation of the epidemiology of bipolar disorder.METHODS: This was a register-based cohort study. All first-ever diagnoses of bipolar disorder (International Classification of Diseases-10: F31) were identified in the nationwide Danish Psychiatric Central Research Register between 1995 and 2012. Causes of death were obtained from The Danish Register of Causes of Death. Age- and gender standardized incidence rates, standardized mortality ratio (SMR) and Kaplan-Meier survival estimates were calculated.RESULTS: We identified 15,334 incident cases of bipolar disorder. The incidence rate increased from 18.5/100,000 person-years (PY) in 1995 to 28.4/100,000 PY in 2012. The mean age at time of diagnosis decreased significantly from 54.5 years in 1995 to 42.4 years in 2012 (p<0.001). The mean time from first affective diagnosis to diagnosis of bipolar disorder was 7.9 years (SD 9.1). The SMR was 1.7 (95%-CI 1.2-2.1). Causes of death were mainly natural; 9% died from suicide.LIMITATIONS: Only patients in psychiatric care were included. The outpatient registry opened in 1995. Patients treated solely in outpatient units are not recorded previously. Systematic studies validating all the clinical diagnoses of the registry do not exist.CONCLUSIONS: The incidence of bipolar disorder has increased in the last 10 years. The SMR was significantly increased. Half of the patients were known to have another affective disorder. This should be considered in future decisions regarding the healthcare organization.
KW - Aged
KW - Bipolar Disorder
KW - Causality
KW - Cause of Death
KW - Cohort Studies
KW - Denmark
KW - Female
KW - Humans
KW - Incidence
KW - International Classification of Diseases
KW - Kaplan-Meier Estimate
KW - Male
KW - Middle Aged
KW - Mood Disorders
KW - Registries
KW - Suicide
KW - Young Adult
U2 - 10.1016/j.jad.2015.04.032
DO - 10.1016/j.jad.2015.04.032
M3 - Journal article
C2 - 26001661
VL - 183
SP - 39
EP - 44
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
SN - 0165-0327
ER -
ID: 162908657