Morbidity of childhood onset narcolepsy: a controlled national study
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Morbidity of childhood onset narcolepsy : a controlled national study. / Jennum, Poul; Pickering, Line; Thorstensen, Eva Wiberg; Ibsen, Rikke; Kjellberg, Jakob.
I: Sleep Medicine, Bind 29, 01.2017, s. 13-17.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Morbidity of childhood onset narcolepsy
T2 - a controlled national study
AU - Jennum, Poul
AU - Pickering, Line
AU - Thorstensen, Eva Wiberg
AU - Ibsen, Rikke
AU - Kjellberg, Jakob
N1 - Copyright © 2016 Elsevier B.V. All rights reserved.
PY - 2017/1
Y1 - 2017/1
N2 - Narcolepsy is associated with significant morbidities. We evaluated the morbidities and mortality in a national group of child and adolescent patients after a first diagnosis of narcolepsy.METHODS: Identified from the Danish National Patient Registry (NPR), 243 patients (128 boys) aged 0-19 years diagnosed with narcolepsy between 1998 and 2012 with follow-up until 2014 were compared with 970 controls who were randomly chosen from the Danish Civil Registration System Statistics and matched by age, gender and geography. Comorbidities were calculated three years before and after diagnoses.RESULTS: In addition to the more frequent health contacts due to neurological diseases, patients showed elevated odds ratios before and after diagnosis of endocrine and metabolic conditions (4.4 (95% CI, 1.9-10.4); 3.8 (1.7-8.4)), nervous disorders (16.6 (8.0-34.4); 198 (49.0-804)), psychiatric illnesses (4.5 (2.3-9.1)/5.8 (2.8-12.1)), pulmonary diseases, and other diseases (3.1 (2.0-4.9); 3.1 (2.0-4.9)). Congenital abnormalities (2.5 (1.1-5.5)), respiratory (2.9 (1.5-5-5)) and eye (5.7 (2.2-15.0)) diseases were more common before diagnosis. Injuries were also more common after diagnosis (1.5 (1.0-2.1)). Narcoleptic children presented significantly more diagnoses of multiple comorbidities than controls before and after diagnosis.CONCLUSION: Before and after a diagnosis of narcolepsy in children, morbidity is more frequent in several domains, including metabolic, psychiatric, neurological and other diseases.
AB - Narcolepsy is associated with significant morbidities. We evaluated the morbidities and mortality in a national group of child and adolescent patients after a first diagnosis of narcolepsy.METHODS: Identified from the Danish National Patient Registry (NPR), 243 patients (128 boys) aged 0-19 years diagnosed with narcolepsy between 1998 and 2012 with follow-up until 2014 were compared with 970 controls who were randomly chosen from the Danish Civil Registration System Statistics and matched by age, gender and geography. Comorbidities were calculated three years before and after diagnoses.RESULTS: In addition to the more frequent health contacts due to neurological diseases, patients showed elevated odds ratios before and after diagnosis of endocrine and metabolic conditions (4.4 (95% CI, 1.9-10.4); 3.8 (1.7-8.4)), nervous disorders (16.6 (8.0-34.4); 198 (49.0-804)), psychiatric illnesses (4.5 (2.3-9.1)/5.8 (2.8-12.1)), pulmonary diseases, and other diseases (3.1 (2.0-4.9); 3.1 (2.0-4.9)). Congenital abnormalities (2.5 (1.1-5.5)), respiratory (2.9 (1.5-5-5)) and eye (5.7 (2.2-15.0)) diseases were more common before diagnosis. Injuries were also more common after diagnosis (1.5 (1.0-2.1)). Narcoleptic children presented significantly more diagnoses of multiple comorbidities than controls before and after diagnosis.CONCLUSION: Before and after a diagnosis of narcolepsy in children, morbidity is more frequent in several domains, including metabolic, psychiatric, neurological and other diseases.
KW - Adolescent
KW - Age of Onset
KW - Child
KW - Child, Preschool
KW - Comorbidity
KW - Denmark
KW - Humans
KW - Infant
KW - Infant, Newborn
KW - Narcolepsy/complications
KW - Prospective Studies
KW - Registries
U2 - 10.1016/j.sleep.2016.09.013
DO - 10.1016/j.sleep.2016.09.013
M3 - Journal article
C2 - 28153208
VL - 29
SP - 13
EP - 17
JO - Sleep Medicine
JF - Sleep Medicine
SN - 1389-9457
ER -
ID: 193898083