Mono-ovulation in women with polycystic ovary syndrome: a clinical review on ovulation induction
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
Standard
Mono-ovulation in women with polycystic ovary syndrome : a clinical review on ovulation induction. / Birch Petersen, Kathrine; Pedersen, Nina Gros; Pedersen, Anette Tønnes; Lauritsen, Mette Petri; Freiesleben, Nina la Cour.
I: Reproductive BioMedicine Online, Bind 32, Nr. 6, 06.2016, s. 563-83.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Mono-ovulation in women with polycystic ovary syndrome
T2 - a clinical review on ovulation induction
AU - Birch Petersen, Kathrine
AU - Pedersen, Nina Gros
AU - Pedersen, Anette Tønnes
AU - Lauritsen, Mette Petri
AU - Freiesleben, Nina la Cour
N1 - Copyright © 2016 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.
PY - 2016/6
Y1 - 2016/6
N2 - Polycystic ovary syndrome (PCOS) affects 5-10% of women of reproductive age and is the most common cause of anovulatory infertility. The treatment approaches to ovulation induction vary in efficacy, treatment duration and patient friendliness. The aim was to determine the most efficient, evidence-based method to achieve mono-ovulation in women diagnosed with PCOS. Publications in English providing information on treatment, efficacy and complication rates were included until September 2015. Systematic reviews, meta-analyses and randomized controlled trials were favoured over cohort and retrospective studies. Clomiphene citrate is recommended as primary treatment for PCOS-related infertility. It induces ovulation in three out of four patients, the risk of multiple pregnancies is modest and the treatment is simple and inexpensive. Gonadotrophins are highly efficient in a low-dose step-up regimen. Ovulation rates are improved by lifestyle interventions in overweight women. Metformin may improve the menstrual cycle within 1-3 months, but does not improve the live birth rate. Letrozole is effective for ovulation induction, but is an off-label drug in many countries. Ovulation induction in women with PCOS should be individualized with regard to weight, treatment efficacy and patient preferences with the aim of achieving mono-ovulation and subsequently the birth of a singleton baby.
AB - Polycystic ovary syndrome (PCOS) affects 5-10% of women of reproductive age and is the most common cause of anovulatory infertility. The treatment approaches to ovulation induction vary in efficacy, treatment duration and patient friendliness. The aim was to determine the most efficient, evidence-based method to achieve mono-ovulation in women diagnosed with PCOS. Publications in English providing information on treatment, efficacy and complication rates were included until September 2015. Systematic reviews, meta-analyses and randomized controlled trials were favoured over cohort and retrospective studies. Clomiphene citrate is recommended as primary treatment for PCOS-related infertility. It induces ovulation in three out of four patients, the risk of multiple pregnancies is modest and the treatment is simple and inexpensive. Gonadotrophins are highly efficient in a low-dose step-up regimen. Ovulation rates are improved by lifestyle interventions in overweight women. Metformin may improve the menstrual cycle within 1-3 months, but does not improve the live birth rate. Letrozole is effective for ovulation induction, but is an off-label drug in many countries. Ovulation induction in women with PCOS should be individualized with regard to weight, treatment efficacy and patient preferences with the aim of achieving mono-ovulation and subsequently the birth of a singleton baby.
KW - Adult
KW - Anovulation
KW - Body Weight
KW - Clomiphene
KW - Female
KW - Fertility Agents, Female
KW - Gonadotropins
KW - Humans
KW - Infertility, Female
KW - Life Style
KW - Metformin
KW - Nitriles
KW - Overweight
KW - Ovulation
KW - Ovulation Induction
KW - Patient Safety
KW - Polycystic Ovary Syndrome
KW - Randomized Controlled Trials as Topic
KW - Reproductive Techniques, Assisted
KW - Retrospective Studies
KW - Triazoles
KW - Journal Article
KW - Review
U2 - 10.1016/j.rbmo.2016.03.006
DO - 10.1016/j.rbmo.2016.03.006
M3 - Review
C2 - 27151490
VL - 32
SP - 563
EP - 583
JO - Reproductive BioMedicine Online
JF - Reproductive BioMedicine Online
SN - 1472-6483
IS - 6
ER -
ID: 177496229