Molecular footprints of aquatic adaptation including bone mass changes in cetaceans
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
Molecular footprints of aquatic adaptation including bone mass changes in cetaceans. / Zhou, Xuming; Sun, Di; Guang, Xuanmin; Ma, Siming; Fang, Xiaodong; Mariotti, Marco; Nielsen, Rasmus; Gladyshev, Vadim N.; Yang, Guang.
I: Genome Biology and Evolution, Bind 10, Nr. 3, 2018, s. 967-975.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Molecular footprints of aquatic adaptation including bone mass changes in cetaceans
AU - Zhou, Xuming
AU - Sun, Di
AU - Guang, Xuanmin
AU - Ma, Siming
AU - Fang, Xiaodong
AU - Mariotti, Marco
AU - Nielsen, Rasmus
AU - Gladyshev, Vadim N.
AU - Yang, Guang
PY - 2018
Y1 - 2018
N2 - Cetaceans (whales, dolphins, and porpoises) are a group of specialized mammals that evolved from terrestrial ancestors and are fully adapted to aquatic habitats. Taking advantage of the recently sequenced finless porpoise genome, we conducted comparative analyses of the genomes of seven cetaceans and related terrestrial species to provide insight into the molecular bases of adaptation of these aquatic mammals. Changes in gene sequences were identified in main lineages of cetaceans, offering an evolutionary picture of cetacean genomes that reveal new pathways that could be associated with adaptation to aquatic lifestyle. We profiled bone microanatomical structures across 28 mammals, including representatives of cetaceans, pinnipeds, and sirenians. Subsequent phylogenetic comparative analyses revealed genes (including leptin, insulin-like growth factor 1, and collagen type I alpha 2 chain) with the root-to-tip substitution rate significantly correlated with bone compactness, implicating these genes could be involved in bone mass control. Overall, this study described adjustments of the genomes of cetaceans according to lifestyle, phylogeny, and bone mass.
AB - Cetaceans (whales, dolphins, and porpoises) are a group of specialized mammals that evolved from terrestrial ancestors and are fully adapted to aquatic habitats. Taking advantage of the recently sequenced finless porpoise genome, we conducted comparative analyses of the genomes of seven cetaceans and related terrestrial species to provide insight into the molecular bases of adaptation of these aquatic mammals. Changes in gene sequences were identified in main lineages of cetaceans, offering an evolutionary picture of cetacean genomes that reveal new pathways that could be associated with adaptation to aquatic lifestyle. We profiled bone microanatomical structures across 28 mammals, including representatives of cetaceans, pinnipeds, and sirenians. Subsequent phylogenetic comparative analyses revealed genes (including leptin, insulin-like growth factor 1, and collagen type I alpha 2 chain) with the root-to-tip substitution rate significantly correlated with bone compactness, implicating these genes could be involved in bone mass control. Overall, this study described adjustments of the genomes of cetaceans according to lifestyle, phylogeny, and bone mass.
KW - Aquatic adaptation
KW - Bone microanatomical structure
KW - Cetacean
KW - Comparative genomics
U2 - 10.1093/gbe/evy062
DO - 10.1093/gbe/evy062
M3 - Journal article
C2 - 29608729
AN - SCOPUS:85054414781
VL - 10
SP - 967
EP - 975
JO - Genome Biology and Evolution
JF - Genome Biology and Evolution
SN - 1759-6653
IS - 3
ER -
ID: 222641699