Moderate- to high-intensity exercise does not modify cortical β-amyloid in Alzheimer's disease
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Moderate- to high-intensity exercise does not modify cortical β-amyloid in Alzheimer's disease. / Frederiksen, Kristian S.; Madsen, Karine; Andersen, Birgitte B.; Beyer, Nina; Garde, Ellen; Høgh, Peter; Waldemar, Gunhild; Hasselbalch, Steen G.; Law, Ian.
I: Alzheimer's & Dementia: Translational Research & Clinical Interventions, Bind 5, Nr. 1, 2019, s. 208-215.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Moderate- to high-intensity exercise does not modify cortical β-amyloid in Alzheimer's disease
AU - Frederiksen, Kristian S.
AU - Madsen, Karine
AU - Andersen, Birgitte B.
AU - Beyer, Nina
AU - Garde, Ellen
AU - Høgh, Peter
AU - Waldemar, Gunhild
AU - Hasselbalch, Steen G.
AU - Law, Ian
PY - 2019
Y1 - 2019
N2 - Introduction: Animal models of Alzheimer's disease show that exercise may modify β-amyloid (Aβ) deposition. We examined the effect of a 16-week exercise intervention on cortical Aβ in patients with mild-to-moderate Alzheimer's disease. Methods: Thirty-six patients with Alzheimer's disease were randomized to either one hour of aerobic exercise three times weekly for 16 weeks or usual care. Pre and post intervention, 11Carbon-Pittsburgh compound B positron emission tomography was carried out to assess cortical Aβ, and quantified using standardized uptake value rations (SUVRs). Results: The intervention showed no effect on follow-up SUVRs in a covariance analysis with group allocation, baseline intervention SUVR, age, sex, and baseline Mini–Mental State Examination as predictors. Change in SUVRs did not correlate with changes in measures of physical or aerobic fitness. Discussion: The present findings do not support an effect of exercise on Aβ. However, the relatively short intervention period may account for a lack of efficacy. Further studies should test earlier and longer interventions.
AB - Introduction: Animal models of Alzheimer's disease show that exercise may modify β-amyloid (Aβ) deposition. We examined the effect of a 16-week exercise intervention on cortical Aβ in patients with mild-to-moderate Alzheimer's disease. Methods: Thirty-six patients with Alzheimer's disease were randomized to either one hour of aerobic exercise three times weekly for 16 weeks or usual care. Pre and post intervention, 11Carbon-Pittsburgh compound B positron emission tomography was carried out to assess cortical Aβ, and quantified using standardized uptake value rations (SUVRs). Results: The intervention showed no effect on follow-up SUVRs in a covariance analysis with group allocation, baseline intervention SUVR, age, sex, and baseline Mini–Mental State Examination as predictors. Change in SUVRs did not correlate with changes in measures of physical or aerobic fitness. Discussion: The present findings do not support an effect of exercise on Aβ. However, the relatively short intervention period may account for a lack of efficacy. Further studies should test earlier and longer interventions.
KW - 11C-PiB-PET
KW - Aerobic exercise
KW - Alzheimer's disease
KW - Dementia
KW - Exercise
KW - Intervention
KW - PET
KW - Randomized
KW - β-amyloid
U2 - 10.1016/j.trci.2019.04.006
DO - 10.1016/j.trci.2019.04.006
M3 - Journal article
C2 - 31198839
AN - SCOPUS:85066842311
VL - 5
SP - 208
EP - 215
JO - Alzheimer's & Dementia: Translational Research & Clinical Interventions
JF - Alzheimer's & Dementia: Translational Research & Clinical Interventions
SN - 2352-8737
IS - 1
ER -
ID: 239159471