Mitral Valve Infective Endocarditis after Trans-Catheter Aortic Valve Implantation
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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Mitral Valve Infective Endocarditis after Trans-Catheter Aortic Valve Implantation. / Panagides, Vassili; del Val, David; Abdel-Wahab, Mohamed; Mangner, Norman; Durand, Eric; Ihlemann, Nikolaj; Urena, Marina; Pellegrini, Costanza; Giannini, Francesco; Scislo, Piotr; Huczek, Zenon; Landt, Martin; Auffret, Vincent; Sinning, Jan Malte; Cheema, Asim N; Nombela-Franco, Luis; Chamandi, Chekrallah; Campelo-Parada, Francisco; Munoz-Garcia, Erika; Herrmann, Howard C; Testa, Luca; Kim, Won-Keun; Castillo, Juan Carlos; Alperi, Alberto; Tchetche, Didier; Bartorelli, Antonio L; Kapadia, Samir; Stortecky, Stefan; Amat-Santos, Ignacio; Wijeysundera, Harindra C; Lisko, John; Gutiérrez-Ibanes, Enrique; Serra, Vicenç; Salido, Luisa; Alkhodair, Abdullah; Livi, Ugolino; Chakravarty, Tarun; Lerakis, Stamatios; Vilalta, Victoria; Regueiro, Ander; Romaguera, Rafael; Kappert, Utz; Barbanti, Marco; Masson, Jean-Bernard; Maes, Frédéric; Fiorina, Claudia; Miceli, Antonio; Kodali, Susheel; Ribeiro, Henrique B; Mangione, Jose Armando; de Brito, Fabio Sandoli; Dato, Guglielmo Mario Actis; Rosato, Francesco; Ferreira, Maria-Cristina; de Lima, Valter Correia; Colafranceschi, Alexandre Siciliano; Abizaid, Alexandre; Marino, Marcos Antonio; Esteves, Vinicius; Andrea, Julio; Godinho, Roger R.; Alfonso, Fernando; Eltchaninoff, Helene; Søndergaard, Lars; Himbert, Dominique; Husser, Oliver; Latib, Azeem; Breton, Hervé Le; Servoz, Clement; Pascual, Isaac; Siddiqui, Saif; Olivares, Paolo; Hernandez-Antolin, Rosana; Webb, John G; Sponga, Sandro; Makkar, Raj; Kini, Annapoorna S.; Boukhris, Marouane; Gervais, Philippe; Linke, Axel; Crusius, Lisa; Holzhey, David; Rodés-Cabau, Josep.
I: American Journal of Cardiology, Bind 172, 2022, s. 90-97.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Mitral Valve Infective Endocarditis after Trans-Catheter Aortic Valve Implantation
AU - Panagides, Vassili
AU - del Val, David
AU - Abdel-Wahab, Mohamed
AU - Mangner, Norman
AU - Durand, Eric
AU - Ihlemann, Nikolaj
AU - Urena, Marina
AU - Pellegrini, Costanza
AU - Giannini, Francesco
AU - Scislo, Piotr
AU - Huczek, Zenon
AU - Landt, Martin
AU - Auffret, Vincent
AU - Sinning, Jan Malte
AU - Cheema, Asim N
AU - Nombela-Franco, Luis
AU - Chamandi, Chekrallah
AU - Campelo-Parada, Francisco
AU - Munoz-Garcia, Erika
AU - Herrmann, Howard C
AU - Testa, Luca
AU - Kim, Won-Keun
AU - Castillo, Juan Carlos
AU - Alperi, Alberto
AU - Tchetche, Didier
AU - Bartorelli, Antonio L
AU - Kapadia, Samir
AU - Stortecky, Stefan
AU - Amat-Santos, Ignacio
AU - Wijeysundera, Harindra C
AU - Lisko, John
AU - Gutiérrez-Ibanes, Enrique
AU - Serra, Vicenç
AU - Salido, Luisa
AU - Alkhodair, Abdullah
AU - Livi, Ugolino
AU - Chakravarty, Tarun
AU - Lerakis, Stamatios
AU - Vilalta, Victoria
AU - Regueiro, Ander
AU - Romaguera, Rafael
AU - Kappert, Utz
AU - Barbanti, Marco
AU - Masson, Jean-Bernard
AU - Maes, Frédéric
AU - Fiorina, Claudia
AU - Miceli, Antonio
AU - Kodali, Susheel
AU - Ribeiro, Henrique B
AU - Mangione, Jose Armando
AU - de Brito, Fabio Sandoli
AU - Dato, Guglielmo Mario Actis
AU - Rosato, Francesco
AU - Ferreira, Maria-Cristina
AU - de Lima, Valter Correia
AU - Colafranceschi, Alexandre Siciliano
AU - Abizaid, Alexandre
AU - Marino, Marcos Antonio
AU - Esteves, Vinicius
AU - Andrea, Julio
AU - Godinho, Roger R.
AU - Alfonso, Fernando
AU - Eltchaninoff, Helene
AU - Søndergaard, Lars
AU - Himbert, Dominique
AU - Husser, Oliver
AU - Latib, Azeem
AU - Breton, Hervé Le
AU - Servoz, Clement
AU - Pascual, Isaac
AU - Siddiqui, Saif
AU - Olivares, Paolo
AU - Hernandez-Antolin, Rosana
AU - Webb, John G
AU - Sponga, Sandro
AU - Makkar, Raj
AU - Kini, Annapoorna S.
AU - Boukhris, Marouane
AU - Gervais, Philippe
AU - Linke, Axel
AU - Crusius, Lisa
AU - Holzhey, David
AU - Rodés-Cabau, Josep
N1 - Publisher Copyright: © 2022 Elsevier Inc.
PY - 2022
Y1 - 2022
N2 - Scarce data exist on mitral valve (MV) infective endocarditis (IE) after transcatheter aortic valve implantation (TAVI). This multicenter study included a total of 579 patients with a diagnosis of definite IE after TAVI from the IE after TAVI International Registry and aimed to evaluate the incidence, characteristics, management, and outcomes of MV-IE after TAVI. A total of 86 patients (14.9%) had MV-IE. These patients were compared with 284 patients (49.1%) with involvement of the transcatheter heart valve (THV) only. Two factors were found to be associated with MV-IE: the use of self-expanding valves (adjusted odds ratio 2.49, 95% confidence interval [CI] 1.23 to 5.07, p = 0.012), and the presence of an aortic regurgitation ≥2 at discharge (adjusted odds ratio 3.33; 95% CI 1.43 to 7.73, p <0.01). There were no differences in IE timing and causative microorganisms between groups, but surgical management was significantly lower in patients with MV-IE (6.0%, vs 21.6% in patients with THV-IE, p = 0.001). All-cause mortality rates at 2-year follow-up were high and similar between patients with MV-IE (51.4%, 95% CI 39.8 to 64.1) and patients with THV-IE (51.5%, 95% CI 45.4 to 58.0) (log-rank p = 0.295). The factors independently associated with increased mortality risk in patients with MV-IE were the occurrence of heart failure (adjusted p <0.001) and septic shock (adjusted p <0.01) during the index hospitalization. One of 6 IE episodes after TAVI is localized on the MV. The implantation of a self-expanding THV and the presence of an aortic regurgitation ≥2 at discharge were associated with MV-IE. Patients with MV-IE were rarely operated on and had a poor prognosis at 2-year follow-up.
AB - Scarce data exist on mitral valve (MV) infective endocarditis (IE) after transcatheter aortic valve implantation (TAVI). This multicenter study included a total of 579 patients with a diagnosis of definite IE after TAVI from the IE after TAVI International Registry and aimed to evaluate the incidence, characteristics, management, and outcomes of MV-IE after TAVI. A total of 86 patients (14.9%) had MV-IE. These patients were compared with 284 patients (49.1%) with involvement of the transcatheter heart valve (THV) only. Two factors were found to be associated with MV-IE: the use of self-expanding valves (adjusted odds ratio 2.49, 95% confidence interval [CI] 1.23 to 5.07, p = 0.012), and the presence of an aortic regurgitation ≥2 at discharge (adjusted odds ratio 3.33; 95% CI 1.43 to 7.73, p <0.01). There were no differences in IE timing and causative microorganisms between groups, but surgical management was significantly lower in patients with MV-IE (6.0%, vs 21.6% in patients with THV-IE, p = 0.001). All-cause mortality rates at 2-year follow-up were high and similar between patients with MV-IE (51.4%, 95% CI 39.8 to 64.1) and patients with THV-IE (51.5%, 95% CI 45.4 to 58.0) (log-rank p = 0.295). The factors independently associated with increased mortality risk in patients with MV-IE were the occurrence of heart failure (adjusted p <0.001) and septic shock (adjusted p <0.01) during the index hospitalization. One of 6 IE episodes after TAVI is localized on the MV. The implantation of a self-expanding THV and the presence of an aortic regurgitation ≥2 at discharge were associated with MV-IE. Patients with MV-IE were rarely operated on and had a poor prognosis at 2-year follow-up.
U2 - 10.1016/j.amjcard.2022.02.034
DO - 10.1016/j.amjcard.2022.02.034
M3 - Journal article
C2 - 35387738
AN - SCOPUS:85127518827
VL - 172
SP - 90
EP - 97
JO - Am. J. Cardiol.
JF - Am. J. Cardiol.
SN - 0002-9149
ER -
ID: 313769798