Milk intake and incident stroke and coronary heart disease in populations of European descent

Milk intake and incident stroke and coronary heart disease in populations of European descent: A Mendelian Randomization study

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Standard

Milk intake and incident stroke and coronary heart disease in populations of European descent : A Mendelian Randomization study. / Vissers, L. E.T.; Sluijs, I.; Burgess, S.; Forouhi, N. G.; Freisling, H.; Imamura, F.; Nilsson, T. K.; Renström, F.; Weiderpass, E.; Aleksandrova, K.; Dahm, C. C.; Perez-Cornago, A.; Schulze, M. B.; Tong, T. Y.N.; Aune, D.; Bonet, C.; Boer, J. M.A.; Boeing, H.; Chirlaque, M. D.; Conchi, M. I.; Imaz, L.; Jäger, S.; Krogh, V.; Kyrø, C.; Masala, G.; Melander, O.; Overvad, K.; Panico, S.; Sánches, M. J.; Sonestedt, E.; Tjønneland, A.; Tzoulaki, I.; Verschuren, W. M.M.; Riboli, E.; Wareham, N. J.; Danesh, J.; Butterworth, A. S.; Van Der Schouw, Y. T.

I: British Journal of Nutrition, Bind 128, Nr. 9, 2022.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Vissers, LET, Sluijs, I, Burgess, S, Forouhi, NG, Freisling, H, Imamura, F, Nilsson, TK, Renström, F, Weiderpass, E, Aleksandrova, K, Dahm, CC, Perez-Cornago, A, Schulze, MB, Tong, TYN, Aune, D, Bonet, C, Boer, JMA, Boeing, H, Chirlaque, MD, Conchi, MI, Imaz, L, Jäger, S, Krogh, V, Kyrø, C, Masala, G, Melander, O, Overvad, K, Panico, S, Sánches, MJ, Sonestedt, E, Tjønneland, A, Tzoulaki, I, Verschuren, WMM, Riboli, E, Wareham, NJ, Danesh, J, Butterworth, AS & Van Der Schouw, YT 2022, 'Milk intake and incident stroke and coronary heart disease in populations of European descent: A Mendelian Randomization study', British Journal of Nutrition, bind 128, nr. 9. https://doi.org/10.1017/S0007114521004244

APA

Vissers, L. E. T., Sluijs, I., Burgess, S., Forouhi, N. G., Freisling, H., Imamura, F., Nilsson, T. K., Renström, F., Weiderpass, E., Aleksandrova, K., Dahm, C. C., Perez-Cornago, A., Schulze, M. B., Tong, T. Y. N., Aune, D., Bonet, C., Boer, J. M. A., Boeing, H., Chirlaque, M. D., ... Van Der Schouw, Y. T. (2022). Milk intake and incident stroke and coronary heart disease in populations of European descent: A Mendelian Randomization study. British Journal of Nutrition, 128(9). https://doi.org/10.1017/S0007114521004244

Vancouver

Vissers LET, Sluijs I, Burgess S, Forouhi NG, Freisling H, Imamura F o.a. Milk intake and incident stroke and coronary heart disease in populations of European descent: A Mendelian Randomization study. British Journal of Nutrition. 2022;128(9). https://doi.org/10.1017/S0007114521004244

Author

Vissers, L. E.T. ; Sluijs, I. ; Burgess, S. ; Forouhi, N. G. ; Freisling, H. ; Imamura, F. ; Nilsson, T. K. ; Renström, F. ; Weiderpass, E. ; Aleksandrova, K. ; Dahm, C. C. ; Perez-Cornago, A. ; Schulze, M. B. ; Tong, T. Y.N. ; Aune, D. ; Bonet, C. ; Boer, J. M.A. ; Boeing, H. ; Chirlaque, M. D. ; Conchi, M. I. ; Imaz, L. ; Jäger, S. ; Krogh, V. ; Kyrø, C. ; Masala, G. ; Melander, O. ; Overvad, K. ; Panico, S. ; Sánches, M. J. ; Sonestedt, E. ; Tjønneland, A. ; Tzoulaki, I. ; Verschuren, W. M.M. ; Riboli, E. ; Wareham, N. J. ; Danesh, J. ; Butterworth, A. S. ; Van Der Schouw, Y. T. / Milk intake and incident stroke and coronary heart disease in populations of European descent : A Mendelian Randomization study. I: British Journal of Nutrition. 2022 ; Bind 128, Nr. 9.

Bibtex

@article{59750073e1a644499da6515edbe55b61,

title = "Milk intake and incident stroke and coronary heart disease in populations of European descent: A Mendelian Randomization study",

abstract = "Higher milk intake has been associated with a lower stroke risk, but not with risk of coronary heart disease (CHD). Residual confounding or reverse causation cannot be excluded. Therefore, we estimated the causal association of milk consumption with stroke and CHD risk through instrumental variable (IV) and gene-outcome analyses. IV analysis included 29,328 participants (4,611 stroke; 9,828 CHD) of the EPIC-CVD (8 European countries) and EPIC-NL case-cohort studies. rs4988235, a lactase persistence (LP) single nucleotide polymorphism which enables digestion of lactose in adulthood was used as genetic instrument. Intake of milk was first regressed on rs4988235 in a linear regression model. Next, associations of genetically predicted milk consumption with stroke and CHD were estimated using Prentice-weighted Cox regression. Gene-outcome analysis included 777,024 participants (50,804 cases) from MEGASTROKE (including EPIC-CVD), UK Biobank and EPIC-NL for stroke, and 483,966 participants (61,612 cases) from CARDIoGRAM, UK Biobank and EPIC-CVD and EPIC-NL for CHD. In IV analyses, each additional LP allele was associated with a higher intake of milk in EPIC-CVD (β=13.7 g/day; 95%CI: 8.4-19.1) and EPIC-NL (36.8 g/day; 20.0-53.5). Genetically predicted milk intake was not associated with stroke (HR per 25 g/day 1.05; 95%CI: 0.94-1.16) or CHD (1.02; 0.96-1.08). In gene-outcome analyses, there was no association of rs4988235 with risk of stroke (odds ratios 1.02; 0.99-1.05) or CHD (0.99; 0.95-1.03). Current Mendelian Randomization analysis does not provide evidence for a causal inverse relationship between milk consumption and stroke or CHD risk.",

keywords = "CHD, dairy, Mendelian Randomization, Milk, stroke",

author = "Vissers, {L. E.T.} and I. Sluijs and S. Burgess and Forouhi, {N. G.} and H. Freisling and F. Imamura and Nilsson, {T. K.} and F. Renstr{\"o}m and E. Weiderpass and K. Aleksandrova and Dahm, {C. C.} and A. Perez-Cornago and Schulze, {M. B.} and Tong, {T. Y.N.} and D. Aune and C. Bonet and Boer, {J. M.A.} and H. Boeing and Chirlaque, {M. D.} and Conchi, {M. I.} and L. Imaz and S. J{\"a}ger and V. Krogh and C. Kyr{\o} and G. Masala and O. Melander and K. Overvad and S. Panico and S{\'a}nches, {M. J.} and E. Sonestedt and A. Tj{\o}nneland and I. Tzoulaki and Verschuren, {W. M.M.} and E. Riboli and Wareham, {N. J.} and J. Danesh and Butterworth, {A. S.} and {Van Der Schouw}, {Y. T.}",

note = "Publisher Copyright: {\textcopyright} The Authors 2021.",

year = "2022",

doi = "10.1017/S0007114521004244",

language = "English",

volume = "128",

journal = "British Journal of Nutrition",

issn = "0007-1145",

publisher = "Cambridge University Press",

number = "9",

}

RIS

TY - JOUR

T1 - Milk intake and incident stroke and coronary heart disease in populations of European descent

T2 - A Mendelian Randomization study

AU - Vissers, L. E.T.

AU - Sluijs, I.

AU - Burgess, S.

AU - Forouhi, N. G.

AU - Freisling, H.

AU - Imamura, F.

AU - Nilsson, T. K.

AU - Renström, F.

AU - Weiderpass, E.

AU - Aleksandrova, K.

AU - Dahm, C. C.

AU - Perez-Cornago, A.

AU - Schulze, M. B.

AU - Tong, T. Y.N.

AU - Aune, D.

AU - Bonet, C.

AU - Boer, J. M.A.

AU - Boeing, H.

AU - Chirlaque, M. D.

AU - Conchi, M. I.

AU - Imaz, L.

AU - Jäger, S.

AU - Krogh, V.

AU - Kyrø, C.

AU - Masala, G.

AU - Melander, O.

AU - Overvad, K.

AU - Panico, S.

AU - Sánches, M. J.

AU - Sonestedt, E.

AU - Tjønneland, A.

AU - Tzoulaki, I.

AU - Verschuren, W. M.M.

AU - Riboli, E.

AU - Wareham, N. J.

AU - Danesh, J.

AU - Butterworth, A. S.

AU - Van Der Schouw, Y. T.

PY - 2022

Y1 - 2022

N2 - Higher milk intake has been associated with a lower stroke risk, but not with risk of coronary heart disease (CHD). Residual confounding or reverse causation cannot be excluded. Therefore, we estimated the causal association of milk consumption with stroke and CHD risk through instrumental variable (IV) and gene-outcome analyses. IV analysis included 29,328 participants (4,611 stroke; 9,828 CHD) of the EPIC-CVD (8 European countries) and EPIC-NL case-cohort studies. rs4988235, a lactase persistence (LP) single nucleotide polymorphism which enables digestion of lactose in adulthood was used as genetic instrument. Intake of milk was first regressed on rs4988235 in a linear regression model. Next, associations of genetically predicted milk consumption with stroke and CHD were estimated using Prentice-weighted Cox regression. Gene-outcome analysis included 777,024 participants (50,804 cases) from MEGASTROKE (including EPIC-CVD), UK Biobank and EPIC-NL for stroke, and 483,966 participants (61,612 cases) from CARDIoGRAM, UK Biobank and EPIC-CVD and EPIC-NL for CHD. In IV analyses, each additional LP allele was associated with a higher intake of milk in EPIC-CVD (β=13.7 g/day; 95%CI: 8.4-19.1) and EPIC-NL (36.8 g/day; 20.0-53.5). Genetically predicted milk intake was not associated with stroke (HR per 25 g/day 1.05; 95%CI: 0.94-1.16) or CHD (1.02; 0.96-1.08). In gene-outcome analyses, there was no association of rs4988235 with risk of stroke (odds ratios 1.02; 0.99-1.05) or CHD (0.99; 0.95-1.03). Current Mendelian Randomization analysis does not provide evidence for a causal inverse relationship between milk consumption and stroke or CHD risk.

AB - Higher milk intake has been associated with a lower stroke risk, but not with risk of coronary heart disease (CHD). Residual confounding or reverse causation cannot be excluded. Therefore, we estimated the causal association of milk consumption with stroke and CHD risk through instrumental variable (IV) and gene-outcome analyses. IV analysis included 29,328 participants (4,611 stroke; 9,828 CHD) of the EPIC-CVD (8 European countries) and EPIC-NL case-cohort studies. rs4988235, a lactase persistence (LP) single nucleotide polymorphism which enables digestion of lactose in adulthood was used as genetic instrument. Intake of milk was first regressed on rs4988235 in a linear regression model. Next, associations of genetically predicted milk consumption with stroke and CHD were estimated using Prentice-weighted Cox regression. Gene-outcome analysis included 777,024 participants (50,804 cases) from MEGASTROKE (including EPIC-CVD), UK Biobank and EPIC-NL for stroke, and 483,966 participants (61,612 cases) from CARDIoGRAM, UK Biobank and EPIC-CVD and EPIC-NL for CHD. In IV analyses, each additional LP allele was associated with a higher intake of milk in EPIC-CVD (β=13.7 g/day; 95%CI: 8.4-19.1) and EPIC-NL (36.8 g/day; 20.0-53.5). Genetically predicted milk intake was not associated with stroke (HR per 25 g/day 1.05; 95%CI: 0.94-1.16) or CHD (1.02; 0.96-1.08). In gene-outcome analyses, there was no association of rs4988235 with risk of stroke (odds ratios 1.02; 0.99-1.05) or CHD (0.99; 0.95-1.03). Current Mendelian Randomization analysis does not provide evidence for a causal inverse relationship between milk consumption and stroke or CHD risk.

KW - CHD

KW - dairy

KW - Mendelian Randomization

KW - Milk

KW - stroke

U2 - 10.1017/S0007114521004244

DO - 10.1017/S0007114521004244

M3 - Journal article

C2 - 34670632

AN - SCOPUS:85119366658

VL - 128

JO - British Journal of Nutrition

JF - British Journal of Nutrition

SN - 0007-1145

IS - 9

ER -

ID: 286486381