Migraine and light: A narrative review
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Migraine and light : A narrative review. / Artemenko, Ada R.; Filatova, Elena; Vorobyeva, Yulia D.; Do, Thien Phu; Ashina, Messoud; Danilov, Alexey B.
I: Headache, Bind 62, Nr. 1, 2022, s. 4-10.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Migraine and light
T2 - A narrative review
AU - Artemenko, Ada R.
AU - Filatova, Elena
AU - Vorobyeva, Yulia D.
AU - Do, Thien Phu
AU - Ashina, Messoud
AU - Danilov, Alexey B.
N1 - Publisher Copyright: © 2022 American Headache Society
PY - 2022
Y1 - 2022
N2 - Objective: In this narrative review, we summarize clinical and experimental data on the effect of light in migraine and discuss future prospects. Background: Effective nonpharmacological treatment of hypersensitivity to light in migraine is an unmet clinical need. Current management strategies primarily consist of seeking a dark room and avoiding light exposure. Advances in the past 2 decades have improved our understanding of the underlying pathophysiology of how migraine is influenced by light. This may provide promising avenues for novel approaches in clinical management. Methods: We searched MEDLINE for articles published from database inception up to September 1, 2021. We used the search term “migraine” with the search terms “light,” “photophobia,” “treatment,” “trigger,” “circadian rhythm,” “environment,” and/or “pathophysiology.”. Results: Light is commonly reported as a trigger factor of migraine attacks, however, early manifestation of photophobia and false attribution is likely the actual cause based on data deriving from retrospective, prospective, and experimental studies. The most common photophobia symptoms in migraine are exacerbation of headache by light and abnormal sensitivity to light with the underlying neural pathways likely being dependent on ongoing activity in the trigeminovascular system. Clinical studies and experimental models have identified mediators of photophobia and uncovered narrow wavebands of the light spectrum that may reduce pain intensity during a migraine attack. Consequently, novel devices have undergone exploratory clinical trials with promising results. Conclusion: False attribution is likely the reason why light is commonly reported as a trigger factor of migraine attacks, and a prospective confirmation is required to prevent unnecessary avoidance. The observation that individuals with migraine are not equally photophobic to all wavebands of the light spectrum opens the potential for innovative pain management strategies. In this context, using human-centric lighting (also called integrative lighting) to mimic the natural daylight cycle and avoid harmful wavebands through modern technology may prove beneficial. Future research should identify direct and indirect consequences of light and other environmental factors in migraine to fill out knowledge gaps and enable evidence-based care strategies within institutions, work environments, and other settings.
AB - Objective: In this narrative review, we summarize clinical and experimental data on the effect of light in migraine and discuss future prospects. Background: Effective nonpharmacological treatment of hypersensitivity to light in migraine is an unmet clinical need. Current management strategies primarily consist of seeking a dark room and avoiding light exposure. Advances in the past 2 decades have improved our understanding of the underlying pathophysiology of how migraine is influenced by light. This may provide promising avenues for novel approaches in clinical management. Methods: We searched MEDLINE for articles published from database inception up to September 1, 2021. We used the search term “migraine” with the search terms “light,” “photophobia,” “treatment,” “trigger,” “circadian rhythm,” “environment,” and/or “pathophysiology.”. Results: Light is commonly reported as a trigger factor of migraine attacks, however, early manifestation of photophobia and false attribution is likely the actual cause based on data deriving from retrospective, prospective, and experimental studies. The most common photophobia symptoms in migraine are exacerbation of headache by light and abnormal sensitivity to light with the underlying neural pathways likely being dependent on ongoing activity in the trigeminovascular system. Clinical studies and experimental models have identified mediators of photophobia and uncovered narrow wavebands of the light spectrum that may reduce pain intensity during a migraine attack. Consequently, novel devices have undergone exploratory clinical trials with promising results. Conclusion: False attribution is likely the reason why light is commonly reported as a trigger factor of migraine attacks, and a prospective confirmation is required to prevent unnecessary avoidance. The observation that individuals with migraine are not equally photophobic to all wavebands of the light spectrum opens the potential for innovative pain management strategies. In this context, using human-centric lighting (also called integrative lighting) to mimic the natural daylight cycle and avoid harmful wavebands through modern technology may prove beneficial. Future research should identify direct and indirect consequences of light and other environmental factors in migraine to fill out knowledge gaps and enable evidence-based care strategies within institutions, work environments, and other settings.
U2 - 10.1111/head.14250
DO - 10.1111/head.14250
M3 - Review
C2 - 35041220
AN - SCOPUS:85123306189
VL - 62
SP - 4
EP - 10
JO - Headache
JF - Headache
SN - 0017-8748
IS - 1
ER -
ID: 344425242