TY - JOUR

T1 - Migraine and cluster headache - the common link

AU - Vollesen, Anne Luise

AU - Benemei, Silvia

AU - Cortese, Francesca

AU - Labastida-Ramírez, Alejandro

AU - Marchese, Francesca

AU - Pellesi, Lanfranco

AU - Romoli, Michele

AU - Ashina, Messoud

AU - Lampl, Christian

AU - School of Advanced Studies of the European Headache Federation (EHF-SAS)

PY - 2018

Y1 - 2018

N2 - Although clinically distinguishable, migraine and cluster headache share prominent features such as unilateral pain, common pharmacological triggers such glyceryl trinitrate, histamine, calcitonin gene-related peptide (CGRP) and response to triptans and neuromodulation. Recent data also suggest efficacy of anti CGRP monoclonal antibodies in both migraine and cluster headache. While exact mechanisms behind both disorders remain to be fully understood, the trigeminovascular system represents one possible common pathophysiological pathway and network of both disorders. Here, we review past and current literature shedding light on similarities and differences in phenotype, heritability, pathophysiology, imaging findings and treatment options of migraine and cluster headache. A continued focus on their shared pathophysiological pathways may be important in paving future treatment avenues that could benefit both migraine and cluster headache patients.

AB - Although clinically distinguishable, migraine and cluster headache share prominent features such as unilateral pain, common pharmacological triggers such glyceryl trinitrate, histamine, calcitonin gene-related peptide (CGRP) and response to triptans and neuromodulation. Recent data also suggest efficacy of anti CGRP monoclonal antibodies in both migraine and cluster headache. While exact mechanisms behind both disorders remain to be fully understood, the trigeminovascular system represents one possible common pathophysiological pathway and network of both disorders. Here, we review past and current literature shedding light on similarities and differences in phenotype, heritability, pathophysiology, imaging findings and treatment options of migraine and cluster headache. A continued focus on their shared pathophysiological pathways may be important in paving future treatment avenues that could benefit both migraine and cluster headache patients.

KW - Calcitonin Gene-Related Peptide/antagonists & inhibitors

KW - Cluster Headache/blood

KW - Deep Brain Stimulation/statistics & numerical data

KW - Humans

KW - Implantable Neurostimulators/statistics & numerical data

KW - Migraine Disorders/blood

KW - Nitroglycerin/adverse effects

KW - Tryptamines/pharmacology

U2 - 10.1186/s10194-018-0909-4

DO - 10.1186/s10194-018-0909-4

M3 - Review

C2 - 30242519

VL - 19

SP - 1

EP - 15

JO - Journal of Headache and Pain

JF - Journal of Headache and Pain

SN - 1129-2369

IS - 1

M1 - 89

ER -